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MK0368

Gene
MK0368
Protein
S-inosyl-L-homocysteine hydrolase
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
424 amino acids
Function
Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
Similarity
Belongs to the adenosylhomocysteinase family.
Mass
47.016 kDa
Sequence
MVVVKEGEYAIRDPSLAPKGRDMIEWARDHMPVLGAIRERFEEERPLEGITVGMTLHLEAKTAVLVETLMAGGAEVAITGCNPLSTKDEVAAALVEEGVHVYAWRGETEEEYYQNIDRVLSHEPDIIVDDGADCIARVHTEFPDLAERVIGATEETTTGVNRLHAMHREGVLKFPVIAVNDAKTKYLMDNRYGTGQSALDGLMRATNILLAGKTVVVVGYGWCGRGIARRARGLGANVIVVEVDPIKAMEAIFDGFRVMPMDRAAEEGDIFITATGNRDVIRGEHIEKMKDGVILANAGHFDVEIDKEYLEEHCEEKIDRRGGLVTEYRMPDGKRVYLIAEGRLVNLAAGEGHPIEIMDISFALQALSVEVLAKEGKEMEPGVYKVPKDVDKRVAELKLESMGIELEELTPEQREYMKSWEEGT