Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Function
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
Similarity
Belongs to the archease family.
Sequence
MPWEEIEHTADAAFRVWADTPEDLLVEAAKALFDLITDLDAVEPEEEVEIEAEGGDLVELLHDWLEEIHFRHEIDGMLFSDFEVKELKKEEGWKVRGVARGEPYDPDRHPFHTEVKAVTYHNMKVEREDGRWVAEYVVDL