Protein
CRISPR-associated protein MJ1674
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Function
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities.
Sequence
MLKVLISPLGVGDTNTDVYKRQYKTAEYKFEGDIDGIESPFVLSVLIEKLKVDKVIVVGTAKSMWEKLYEYYAKEVGEFDEEYWIEIGKKVGMSKYDNYALSEEDLKKIEKVIDKYLKKINPNAVGGSKCKIIKYGIDKDEIWENFDLFMSLINEVNDGDEIYLDITHSFRSIPLFMYVMLEFMRYFKNVKLKGIYYGMLDVIRELGHAPVVDLSPIFEISEWIRGMYEFTTYGNSYLISKLLENEDKEIAEKLQKISRYIDANYLKELREEVKTLKPLLNEKKDTGRFLKYFIPELHKFIDKLKYEDSDFEFQISMAKWNFDNKKYSSGYLCLTDSIFWKLCELYNLPSVYKNREVMKGIIYNPSLNKKYSAFGSIKDMHYKRLRNIRNKIAHADVSKKGDDFNPENDLEDVVNLLKNVNLPDFDKIIEDLLLDVKNNQNNKTLKLLKNILNIQIIRKIIKAYNFESNEIYWDFVSGYLLNKNNKCNNEKLREIIEIFHKNIEDAGELEEAFNFVKNTEDEELLDSLALQNAIMHYALFKLSNAYNIKNKEDKEAIKWVLLNQNLCSKHPILKEINNNYHKIFKNKDKPMSNEILEASKNIIRLLNSDLSEIKDSVPLNLIIIRYRSYKNNRR