MJ1478

tRNA-5-methyluridine(54) 2-sulfurtransferase

303 amino acids

Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T) (By similarity). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity).

Belongs to the TtcA family. TtuA subfamily.

35.543 kDa

MVKTMKCKFCDKKSYIKLKSPKMYLCKEHFVEYFENKVKKSIDKYKMLSKDEKILVAVSGGKDGHAAAWVLKKLGYNIELFHINLGIEGFSEESLKAVKELAEKLEVPLHVVNLKDITGKTMEDIRGKKCSICGTTKRYLMNKFGYENGFDVIVTGHNLDDEVSFILNNLFNWNIRYLAKHEPVLPAHDKFLKKVKIFFEIEEELILKYAEAEEIPYTTVECKYAERAITLKHRAYLNELEKERPGIKYQFLSGYMKNRHLFKVEEEDFQFRECEVCGMTSAGKICSFCRVWKLYKKKKENRN