Protein
7,8-dihydro-6-hydroxymethylpterin dimethyltransferase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Function
Is responsible for the addition of methyl groups at C-7 and C-9 of the pterin ring during methanopterin (MPT) biosynthesis. Catalyzes methylation of 7,8-dihydro-6-hydroxymethylpterin, likely using methylenetetrahydromethanopterin as a methyl group donor, via a radical-based mechanism.
Similarity
Belongs to the radical SAM superfamily.
Sequence
MEKKTLSLCPICLKRIPATILEEDGKIIIKKTCPEHGEFKDIYWGDAELYKKFDKYEFIGKIEVTNTKVKNGCPYDCGLCPNHKSTTILANIDVTNRCNLNCPICFANANKSGKVYEPSFEDIKRMMENLRKEIPPTPAIQFAGGEPTVRSDLPELIKLARDMGFLHVQLATNGIKLKNINYLKKLKEAGLSTIYLQFDGISEKPYLVARGKNLLPIKQKVIENCKKVGFDSVVLVPTLVRGVNDNEVGGIIRYAAENVDVVRGINFQPVSFTGRVDEKTLLEGRITIPDFIKLVEEQTDGEITEEDFYPVPSVAPISVLVEKLTNDRKPTLSSHQHCGTSTYVFVDEDGKLIPITRFIDVEGFLEIVKEKIEEIGKSKMHDVKVLGEIALKLPSLIDLDKAPKSVNIKKIIDLILSVLKSDYSALAELHYHMLMISCMHFMDAYNFDVKRVMRCCIHYATPDDRIIPFCTYNTLHRQEVEEKFSIPLEEWKRMHKIGGEDDREDY