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MJ0392

Gene
MJ0392
Protein
Zinc metalloprotease MJ0392
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
339 amino acids
Function
A site-2 regulated intramembrane protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains; its endogenous substrate is unknown. Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein. Possible signals, S1P and substrates are unknown in this organism.
Similarity
Belongs to the peptidase M50B family.
Mass
37.965 kDa
Sequence
MNYSIRLFKIMGIPIELHITFILFLVVIIGLSIMNNSIFWAVLFILLFVSVVLHELGHSYVAKKYGVKIEKILLLPIGGVAMMDKIPKEGELRIGIAGPLVSFIIGIVLLIVSQFFDININGYPLLYTLSLLNLMLGGFNLIPAFPMDGGRILRAILSKKYGYLKSTKIAANIGKSLALIMLLFGLLSMNIILILVSLFVYFGAEQESRVVEVETIFKNIKAKDIMTPNPVYVTPDMSIEEFLDFMLKHKYFGYPVVENGKLVGCIGIGNIHKKEGTVRDYMEKPVVVSEDTDIKEILRKMANTDRVFVVEGGKLKGIISKTDILRAMSILELKEELKD