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MIS12

Gene
mis12
Protein
Centromere protein mis12
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
259 amino acids
Function
Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct segregation of chromosomes and for maintaining the inner centromere structure.
Similarity
Belongs to the mis12 family.
Mass
30.195 kDa
Sequence
MLVELLEFTPLSFIDDVINITNQLLYKGVNGVDKAFSQTRFAKKAPQEIEEGLHKFEVLFESVVDRYYDGFEVYTLRNIFSYPPELKGYMRTFGKDVDYSITTEQDAAMDQAIQEAAEKLVVKMQLRRDLRMRLSRKREKKTEIEKHLERISFLNKVPENWQVTLPETTDFLLDQLGNLQHAVKRVVEASPTVHSREVDERITYLEKGYERLSNPIDQQKDFWSHHLSKLESTANTETANNIHKLLLSSEKDVGHTDEP

Gene
MIS12
Protein
Protein MIS12 homolog
Organism
Arabidopsis thaliana
Length
238 amino acids
Function
Constitutive component of kinetochores that is essential for proper cell division during mitotic cell cycle (Probable). May play a role in the modulation of centromere during meiosis (PubMed:21695238).
Similarity
Belongs to the mis12 family.
Mass
27.126 kDa
Sequence
MEGSKSEAVFDSMNLNPQIFINEAINSVEDYVDQAFDFYARDASKSLKIKGSDKQKSQALSNGIARVRGLLLSVIDNRLKLWESYSLRFCFAVPDGFVLPKSEESSSVHQDGLYDLELDAELDSLRDKLNVVGKRSVELDSELQALERSSVSRERSLRLVNEALELYDESSMDEIFKEMTKMASELRASVERLKTRRMKASESAKVKRLKNHGKEFSAMTFDGKLEDLEKFQAELRKM

Gene
MIS12
Protein
Protein MIS12 homolog
Organism
Gallus gallus
Length
210 amino acids
Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
Similarity
Belongs to the mis12 family.
Mass
24.691 kDa
Sequence
MSVRPMAYETQFFGFTPQTCMLRIYLAFQDYLFEMMVVVESVILKKLEALPAVQISRFEIRKSTEKFLHFMKARFDQLFEKMEEVLLQLVLSIPDNVLLPEDRVHQQYPYSQEEFCALQDEISQLQQQCRAEAAAGQALRAELEEQRAVQAELEKVVQWFDGLENVCREHGTGNFKESLVFLTQNCKKLQDVLRDVEEKSKKIKKRQQLL

Gene
MIS12
Protein
Protein MIS12 homolog
Organism
Bos taurus
Length
206 amino acids
Function
Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Essential for proper kinetochore microtubule attachments.
Similarity
Belongs to the mis12 family.
Mass
24.159 kDa
Sequence
MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCAISPVEIRKCTEKFLCFMKGRFDNLFGKMEQLFLQLILRIPPNVLLPEDKSQETQSYSEEEFHFLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLSLFDELENVGRDHGASDFREGLVFLIQNSRKLQNIRENVEKEGKRLKIS

Gene
Mis12
Protein
Protein MIS12 homolog
Organism
Mus musculus
Length
206 amino acids
Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
Similarity
Belongs to the mis12 family.
Mass
24.131 kDa
Sequence
MSVDPMAYEAQFFGFTPQTCLLRIYVAFQDHLFEVMQAVEQVILKKLEDIPNCEITPVQTRKCTEKFLCFMKGRFDNLFGKMEQLILQSILCIPPNILLPEDKCQETNPFSEEKLELLQQEIKELQEKYKVELCTEQALLAELEEQKTVKAKLRETLTFFDELENIGRYQGTSNFRESLASLVQSCRKLQSIRDNVEKESRRLETQ

Gene
Mis12
Protein
Protein MIS12 homolog
Organism
Rattus norvegicus
Length
206 amino acids
Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
Similarity
Belongs to the mis12 family.
Mass
24.161 kDa
Sequence
MSVDPMAYEAQFFGFTPQTCLLRIYIAFQDHLFEVMQAVEQVILKKLEGIPDCEISSIQTRKCTEKFLCFMKGRFDNLFGKMEQLILQSILQIPPNILLPEDKCQETNPFSEEKFQLLKQEIKELQEKYKVELCTEQALLAELEEQKTVKAKLRETLTFFDELENIGRYQGTSNFRESLVSLVQNCRKLQDIRDNVEKEGKRLETQ

Gene
MIS12
Protein
Protein MIS12 homolog
Organism
Homo sapiens
Length
205 amino acids
Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108).
Similarity
Belongs to the mis12 family.
Mass
24.14 kDa
Sequence
MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQIRKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVSLVQNSRKLQNIRDNVEKESKRLKIS

Gene
MIS12
Protein
Protein MIS12 homolog
Organism
Pongo abelii
Length
205 amino acids
Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.
Similarity
Belongs to the mis12 family.
Mass
24.14 kDa
Sequence
MSVDPMTYEAQFFGFTPQTCMLRIYIAFQDYLFEVMQAVEQVILKKLDGIPDCDISPVQIRKCTEKFLCFMKGHFDNLFSKMEQLFLQLILRIPSNILLPEDKCKETPYSEEDFQHLQKEIEQLQEKYKTELCTKQALLAELEEQKIVQAKLKQTLTFFDELHNVGRDHGTSDFRESLVSLVQNSRKLQNIRDNVEKESKRLKIS