Protein
Bifunctional dihydrofolate reductase-thymidylate synthase
Organism
Acanthamoeba polyphaga mimivirus
Function
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
Similarity
In the C-terminal section; belongs to the thymidylate synthase family.
Sequence
MKKFNIIAAINNDSIIGVKEYGTFSMPWPYLKDDMNHFRKITTDTGSIESGVNAIIVGFNTWQTLPSSYRNIRSRFNIVISRDDETDGQFHKYVKTFDEAIEFASSLTNLNEIFVIGGGVIYDLALKHKLLDKLYLTHVGSNYPIDDNVEKVVHFPLTWSKIEKMCDSNFLELDSEISKHDIGKNILLRFQEYSVKKELYWAIEYLKKNTSLDNKGIIGDKGATGSKGYSLEQHDYYSTEYFWNFYEFITRKVFDLFNSSNEISIPSEECPENQYIELVKTIMEKGIVKQTRNSITKSIFGYQLKYDLSKGYPIQTIKRSYPKAIFEELMWMIRGQTDVSILQKKGVHVWDKNSSKDFLSKYNLPYEEGDIGPGYGFQMRYWGAEYTDCKTSYQGQGIDQLNKCIESIQNNPHDRRIMINLWNCSDLDKMALAPCHFCYMFGVDLYEVPTTSGKKGRLNCHLVQRSWDVLLGWNTTTAALLTYLIANHCDLDPGILVHSISDAHIYQSHIDSGAISQLLQRKCRKFPNLVIRNKKEKIDDYEFDDLIIENYYPCPSISAEMIA