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MIEF2

Gene
mief2
Protein
Mitochondrial dynamics protein MID49
Organism
Xenopus laevis
Length
463 amino acids
Function
Mitochondrial outer membrane protein which regulates mitochondrial organization (By similarity). It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins (By similarity). Regulates DNM1L GTPase activity (By similarity).
Similarity
Belongs to the MID49/MID51 family.
Mass
51.991 kDa
Sequence
MAELQIRKKEKKSGDGIGTMVDFLLANARLVLGVGGAAMLGIATLAVKRLIDRATSPPSDKEAEEKAEQKSIEESWKEAVLKKASPTLRRKEDLEHHCAPLSLPDPSQKMPEATGTSQVKASDEIKKIPICFTLQERLLNYHTHHASVPEVQMEEARQLVLDIKKELQEFLHAKHPEMPFLALHLGGSFGNRLPMSCLDHACLIMPLVLEPDLWCVIPGQKTILSDPNFCMVKRIDLEYTSRGSSPWDRFLVGAYLSSRTMVQSLHKTIVGSINWPAIGTVLDCTIKPDITSDELKLEVVHPNGHMIIRILPMAVIKDADLLAHCCATAPAENLWQRSFYKKEVSRLQELDSSDSGIRLKCLQILKGICRDCPSLCHLNSTHLRHILLHLSTESSDWTETALADRFLQVLEELIGYLDKGFLPSYFNDKLNLFSSLKAEDIEELGYGLYQVFSEPDDVLKRER

Gene
MIEF2
Protein
Mitochondrial dynamics protein MID49
Organism
Homo sapiens
Length
454 amino acids
Function
Mitochondrial outer membrane protein which regulates mitochondrial organization (PubMed:29361167). It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity.
Similarity
Belongs to the MID49/MID51 family.
Mass
49.269 kDa
Sequence
MAEFSQKRGKRRSDEGLGSMVDFLLANARLVLGVGGAAVLGIATLAVKRFIDRATSPRDEDDTKADSWKELSLLKATPHLQPRPPPAALSQPVLPLAPSSSAPEGPAETDPEVTPQLSSPAPLCLTLQERLLAFERDRVTIPAAQVALAKQLAGDIALELQAYFRSKFPELPFGAFVPGGPLYDGLQAGAADHVRLLVPLVLEPGLWSLVPGVDTVARDPRCWAVRRTQLEFCPRGSSPWDRFLVGGYLSSRVLLELLRKALAASVNWPAIGSLLGCLIRPSMASEELLLEVQHERLELTVAVLVAVPGVDADDRLLLAWPLEGLAGNLWLQDLYPVEAARLRALDDHDAGTRRRLLLLLCAVCRGCSALGQLGRGHLTQVVLRLGEDNVDWTEEALGERFLQALELLIGSLEQASLPCHFNPSVNLFSSLREEEIDDIGYALYSGLQEPEGLL

Gene
Mief2
Protein
Mitochondrial dynamics protein MID49
Organism
Mus musculus
Length
454 amino acids
Function
Mitochondrial outer membrane protein which regulates mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity.
Similarity
Belongs to the MID49/MID51 family.
Mass
49.624 kDa
Sequence
MAEFSQKQRKQSGSEGLGSVVDFLLANARLVLGVGGAAVLGIATLAVKRLIDRATSPPDEDDTKGDSWKELSLLRATSPQKPQPPPAAFSQPLATGSPSPSVPVEPTPIHSPTTPKFSTIAPLCLTFQERLLAFERKHVITPEAHVTLAKQLAGDIALELQAYLRSKFPELPFGALVPGGPLYDGLQAGTAEHVRLLAPLELEPGLWSLVPGVDTVAREPRCWAVRRTQLEFHPRGCSPWDRFLVGGYLSSRVLLELLRKALSASVNWPAIGSLLGCLIWPDVASEELLLKVQHECLEFTLAVLMVVPGASTDDRLLLAWPLEGLASNLWLQDLYPVETARLRALDDQDAGTRRRLLLLLCGICRGHPALVRLGWSHLTQVVLHLGEEEVAWTEEALGERFLQALEFLVGSLEQASLPCHFNPSVNLLGNFREEEIDDIGYVLYSGLQVPESLF

Gene
MIEF2
Protein
Mitochondrial dynamics protein MID49
Organism
Pongo abelii
Length
454 amino acids
Function
Mitochondrial outer membrane protein which regulates mitochondrial organization (By similarity). It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins (By similarity). Regulates DNM1L GTPase activity (By similarity).
Similarity
Belongs to the MID49/MID51 family.
Mass
49.27 kDa
Sequence
MAEFSQKRGKRRGDEGLGSMVDFLLANARLVLGVGGAAVLGIATLAVKRFIDRATSPRDEDDTKADSWKELSLLKATPHLQPRPPPAALSQPVLPLAPSSSAPEGPAKSDPEVTPQLSSPAPLCLTLQERLLAFERDRVTIPAAQVALAKQLAGDIALELQAYFQSKFPELPFGAFVPGGPLYDGLQAGAADHVRLLVPLVLEPGLWSLVPGVDTVARDPRCWAVRRTQLEFCPRGSSPWDRFLVGGYLSSRVLLELLRKVLAASVNWPAIGSLLGCLIRPSMASEELLLEVQHERLELTVAVLVAVPGVDADDRLLLAWPLEGLAGNLWLQDLYPVEAARLRALDDRDAGTRRRLLLLLCAVCRGCSALGQLGRGHLTQVVLRLGEDNVDWTEEALGERFLQALELLIGSLEQASLPCHFNPSVNLFSNLREEEIDDIGYALYSGLQEPEGLL