About Products Protein Database Contact

MIA40

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
406 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
43.212 kDa
Sequence
MFRVSLQATRRVAFRSARQIRFYSAHPPSGGVSHMNKPALLLAGFSTLGAIYVADGCPTLIERKPAPAEKPAEETPAAGQSQSISEPTKDADESPVSAQEEGAEPVTTPENEITYSEETHQALAATLSGDEPAAIEPVAESVNEQATEPAASGEATNEPVTGISEDTKAPSLSFDDSKTAKGVVLEDEADKKEIQQTSPDAVKTASKDGSEGESDVVLHEKSPAEAETITEAEEQAEIRSISGGTAEQSATAAAAAAGVQGEKKNEQQTAYNPETGEINWDCPCLGGMAYGPCGEEFKSAFSCFVYSEADPKGINCVEKFSTMQNCFRKYPDYYAEQIKDEEEASAEASKIEDKSTTPVSTATSTVEVQTENAVFEPVLEKYVEENPQLKDTPEAAAVTNTDDEKK

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
404 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
44.619 kDa
Sequence
MVSAVSRQLVNRQLNRVLLRNARIAPFARATRFYSSKYAQESENAKRHKMGLLIAGVAVAGAIVFVTPPQWKKYFRAAKKVEEVAESKEDPVSEAAEEVSESVQESTEEPQQSQEKETADVGNEQAQDESASSGDSEAKKAHDEFADQNEASEKESAPMGESADADQTAKDETVAEKTGNSKSESSESDQSEQDILSSDLEETMETVSEADKELHQISDNTVLSSEEDKTPKAEELKSTSPSGNDEEPKKEDDSSKTIHSLNSEKDMEAVEEEVKQESAYNPDTGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSEAEPKGIDCVEKFQHMQDCFRRYPEHYAEQLADPADDENVDHEKNLSEGKDTGVDSTPPKDEAYLKTEKEKKIEENASPDEDTASKKD

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
403 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced MIA40 is reoxidized by FAD-linked sulfhydryl oxidase ERV1.
Mass
44.536 kDa
Sequence
MLRNLVVRNACRNRPSIQVARGLCRHQTRRLMASSPQFGRNSNQEKTAGFIMGILSMAGALYFIAPNRKPLFASRKVESDKTAEEELSSGGEQSPENEDDNNSKSDENGDDNDSKNDETEAGPQLGGDKIGASKVAEDGELVVLAEEDNKSSEDKDTDESKVSTKDDEQSNEDNATANNQKDENISSENSEENTSDKTLDNNAGSSEKKDPEHSDDEKSQQGQSDDKTTTEDNNGEEESSKKTVSDSENSAKQSESSDEEKEELRKQEEKQMGPTEEEVQHEGAYNPDTGEINWDCPCLGGMAHGPCGEEFKSAFSCFVYSEAEPKGIDCVEKFQHMQDCFRKYPEHYAEQLKETSDDEEPQDKVKVNTIESAPNVSSAKENAAKKAEQSDVKKEPLNEESKP

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
368 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
39.753 kDa
Sequence
MYRNTMRSASRPVIASLRSSTIRAAPRRFASTAPADKPRSFKGSLVRLGLAFGAVYYYNTSPIFADEAISKTVPAPAAFSDDDLPTVDSIVEEKRKQIKAKSEETAASSKTPESQQSNPQTAAADGSPAALEEEAGQQGAFNPETGEINWDCPCLGGMADGPCGEEFKTAFSCFVFSQEEPKGMDCIDKFQGMQECFKKYPDIYGAELADDEDGAPTPDFGDEQPSGEPTTAEVKSNGELARETKDKTAADATKFDDSQKPAESKTPAKTTSTSTDSAQKPAVDAHRDAEPKSDAETASSGSRMVQDVAIPIEKPVNDKYWQDMHKSEVQKKEVTVGITQAHDATAANEEIKHIERQEAAKKNAEKKQ

Gene
mia40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
313 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
34.915 kDa
Sequence
MFAKNLLFRFPKCIRINGYNNMRRSLLQRNGFQAGICRKFGTATKTDVWKGRFLPIVSGVAAASLTAGYLLGKNTSNASSSQDNDHPVVGEHVHTETQSYNEPYMQRHRIEDAIEKKMTSETQPSTDEKGRKVSATENSAPKKTDKEKSSGETAGNILREQIATGKDDDEYARKFEEVEEESSEESAFNPDTGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSKSEPKGMECLDKFQAMQACFQKHPEIYQDMVGESEEEDAETNEKPSTTSDENNQPQSPPSDNASNPEEDVMNMEKEIVNLTPMSVIKEI

Gene
mia40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
297 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
31.948 kDa
Sequence
MFRPATRILLRAPGVAARGPVSRRLISTAPPDAKSRSWKSTIVRLGLAAGAVYYYNTSSVFAEQPSLSFLSKQSTPDSSDETQLPTIDSIKPRIREERQAESKAVSQPDAQPTQHEALSASEAALKSPQELEDEAGQEAAFNPETGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSTEEPKGMDCIDKFKGMQECFRRYPDVYGAELEDDDEADAAAATAAGVSEPSEQPASPTVSAPTAEIDASSDSEGKEGRAKDVHAQVKSEVAEKAEQAESDDLVPKAWHDTEGTKAQQTEK

Gene
mia40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
283 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
30.339 kDa
Sequence
MFRPASRALLRAPTPAVGVARGPTRRFISSSTGSTKPRSWKNTFIRVGLASGAVYYYNTSSVFAETPSLSFRPEAQPKHEDGKSLPTLDSIKPKSREEKKAPAAAADAAATPASTGANAQSESPLKSAEELEAEADQQAAFNPETGEINWDCPCLGGMAYGPCGEEFRAAFSCFVYSEEEPKGMDCIDKFKAMQDCFRAHPDVYGAELDDDEEAGAEANAAGVEQPLAAEVDASVPVEKHEQAKEVRDEVKSAAGEVAESEEVVPKALDVSEQEKTPEQQTEK

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
266 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
27.79 kDa
Sequence
MFRQVSVRALRRAAGRSVCASRAQMVRHSSTLGGGKGSYNLDMPALALAAGVTLLAGYMVYPRAPKAKQAAVQSVAPVNENVEQASASLQASAPVQATSESAEAGEEEAYGEESGAVNEEAAGEPEEAAAEVGETQAEQAPAVETEQAAEAEQAAEAAAEDKASAGEAAQGQQGAYNPDTGEINWDCPCLGGMAHGPCGEEFKAAFACFVYSEAEPKGIDCVEKFQVMQDCFRQHPEHYAEQLESEEQAVRETEAAAESAKSDEGH

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
252 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
27.93 kDa
Sequence
MYRTISRSSSGLIRQSTARLTRQLSTTRTTPSQYNSKLLLGVLGTGALAFGYFSQQSSLIQNASTAENIEKVFEEGNAVAKDAQESLDARQEKVIKENEQKTKKAEDAKTSSESKANVADKKSNSQPEGEPEGEGKQEAAFNPDTGEINWDCPCLGGMAHGPCGEEFKEAFSCFVFSETEPKGIDCIKKFENMRSCFKRYPEHYKDELYDDGEEEASTEVVEHVVLETSEPAIEQIEQGIKEDKVKPNTKSD

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
249 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
27.859 kDa
Sequence
MYRLATRRVLAQTTQTFSKRTFSNQGFRAAKASKTNMYLGAGIALIPVIMSINYLNGNHIANEVDENKVEEGKKKAESTGKKEFVEKAEKEAIGKADVKTKVPAEEANPETRTETDKPSEESQKDEENSYEGAAYNPETGEINWDCPCLGGMAHGPCGEEFKEAFACFIYSESEPKGIECIKKFESMRNCFREHPEHYKEELYDDEEQEPLVDVNEKKGDASEQSAETIADDATKVVKEKAKAEDSNTK

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
247 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
26.545 kDa
Sequence
MLSSKLVACSAGRSVQRISRTFLPAMRGVATKAAAGPSRQSALSSYSIAAVTAIGVGASFYALQSRSSAIQCEPRQAWHDRLKPKEAKGDATLHKDAHTRHAPAEVQDERVEPVEETPVAIEVAVEESEEQTGQQSAYDPETGEINWDCPCLGGMAHGPCGEQFKLAFSCFVYSEAEPKGIDCVDKFKAMQDCFREHPDVYKDEIEDDEAANAQFEKEEANAKSNGLNDAAQEAVEESSGGKEGASA

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
242 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
26.077 kDa
Sequence
MFARSFSNASRTIARRSLSTRSGPAPSSLWSSRNAVIAGTTLAITALAVTSERRKVFNESAQKATSPRDSIIAQDSLKENVHKKSVRQDEFSGESTKPEASTSSDSVEKAADDAAQILEEKEAEASEPSQGAYNPETGEINWDCPCLGGMATGPCGEQFKAAFSCFVYSEAEPKGVDCVELFKVMQDCFREHPEIYGEVDTLGLVLMFYAEIDDDEAPPQEGTMEEKVEAAKEETAAPAAAP

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
242 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
26.051 kDa
Sequence
MFARSFSNASRTIARRSLSTRSGPAPSSLWSSRNAVIAGTTLAITALAVTSERRKVFNESAQKATSPRDSIIAQDSLKENVHKKSVRQDEFSGESTKPEASTSSDSVEKAADDAAQILEEKEAEASEPSQGAYNPETGEINWDCPCLGGMATGPCGEQFKAAFSCFVYSEAEPKGVDCVELFKVMQDCFREHPEIYGEVDTLGLVLMFYAEIDDDEAPAQEGTMEEKVEAAKEETAAPAAAP

Gene
mia40
Protein
Mitochondrial intermembrane space import and assembly protein 40
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
187 amino acids
Function
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
Mass
20.379 kDa
Sequence
MFRPASRALLRAPAVARGPASRRLISTAPAESKPRSWKNTAVRLGLAAGAIYYYNTSNVFAENPSFSLNNQLKKNSAEEPLPTLDSIKPRIREERESAAPKPNAEQAPAQELPFGEGAVKSPQELEEEAGQEAAFNPETGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSEEEPKGMDCIEKFKCV

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40 homolog
Organism
Arabidopsis thaliana
Length
162 amino acids
Function
Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (Probable). Involved in the mitochondrial oxidative folding of the copper-zinc superoxide dismutase CSD1, the copper chaperone for superoxide dismutase CCS, and subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in the peroxisomal oxidative folding of the copper-zinc superoxide dismutase CSD3, and the fatty acid beta-oxidation multifunctional protein AIM1 (PubMed:20829360).
Mass
17.367 kDa
Sequence
MGQAQSDENSIPTTTTTNTPPPSANSPRDSEDTSSPSMDSLLAEAAAYGEDDNENESLEAKAQRALDCPCIADLRNGSCGSQFSEAFLCFLKSTAEEKGSDCVNPFVALQSCINANPDAFSKSVTGDEKETEKKEEQPPVQDHRIIPPLWAKDPPRSGNSKL

Gene
MIA40
Protein
Mitochondrial intermembrane space import and assembly protein 40 homolog
Organism
Oryza sativa subsp. japonica
Length
151 amino acids
Function
Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space.
Mass
16.099 kDa
Sequence
MGQGLSQPAQAVEEPSPPAVEAAPSSSPSPAPAPSSLEALAAEAMSFDEDGNESIDVKVQKALDCPCVAELKNGPCGSQFVDAFSCFLKSTEEEKGSDCVKPFIALQDCIKINPEAFSKEILEEEENDEEAEKSNLKVRAPAWSRESKPKL