mgme1

Mitochondrial genome maintenance exonuclease 1

347 amino acids

Single-stranded DNA (ssDNA) metal-dependent exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity).

Belongs to the MGME1 family.

39.949 kDa

MKPLQQIHLTCRRIIRDVLQHKSFLPAFISTSCTCLSRKKKHNGYDEVNQAKYEGLVRTVTASRISPQTPDRLFEEDNFLFGKVVKSKTATQTPEPKAPQNWVPLSNPNKVSLPLEKTDFDLPLKISLPARNHMANGTIPSVTRILQQTMPMEQAFYLERWKQRMIMELGEQGFAEYTAALFSQGKQFHMQLEDLLLALDHGKKEEPEGSTGYLSSVQHVLTDIIGVKSLESAVHHSELQYLGLVDCVAEYRQKLCVIDWKTSEKPKPYIRDTFDNPLQIAAYIGAINHDNNYNFQVNCGLIVVAYKDGSPAHTHFMDTDLCLHFWNKWLLRLEEYKKKKEEKEKQQ

MGME1

Mitochondrial genome maintenance exonuclease 1

344 amino acids

Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.

Belongs to the MGME1 family.

39.421 kDa

MKMKLFQTICRQLRSSKFSVESAALVAFSTSSYSCGRKKKVNPYEEVDQEKYSNLVQSVLSSRGVAQTPGSVEEDALLCGPVSKHKLPNQGEDRRVPQNWFPIFNPERSDKPNASDPSVPLKIPLQRNVIPSVTRVLQQTMTKQQVFLLERWKQRMILELGEDGFKEYTSNVFLQGKRFHEALESILSPQETLKERDENLLKSGYIESVQHILKDVSGVRALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPFIQSTFDNPLQVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE

Mgme1

Mitochondrial genome maintenance exonuclease 1

338 amino acids

Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.

Belongs to the MGME1 family.

38.391 kDa

MKLPLTFCRLLSRLNRFSVKASPPVSFSTFSYLCSQKKKNSYEAVDQAKYSRLVRSVLSRGPAQTPESLFKEDDVLYGPVSKHKAAEPEPQARVPQHCFPIFNEERTGKPHTDASSSPLKIPLQRNSIPSVTRILQQTMPPEQSFFLERWKERMVLELGEDGFAEYTSNVFLQGKQFHKALESILSPQENLTGGEEHPQCGYIESIQHILTEISGVQALESAVQHEALKYVGLLDCVAEYRGKLCVIDWKTSEKPKPLIRNTYDNPLQVVAYMGAVNHDAHYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTEKQKNLSAPEPA