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MGL_1839

Gene
MGL_1839
Protein
Very-long-chain 3-oxoacyl-CoA reductase
Organism
Malassezia globosa (strain ATCC MYA-4612 / CBS 7966)
Length
324 amino acids
Function
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
35.967 kDa
Sequence
MIETCLCWVGGIFIVTCIAYVVYVALEVHVFPGRSLTTYGANPKLRGAGSWALVTGATDGIGREFAMQLAARGFNIVAVSRTAEKLAILSKEIESTMPGIKTCYYAMDFLSAGNAEYEGLEQLIRHLDIAVLVNNVGLSHTMPVNFLEMDGRELASICQVNIVATMQVTRVVAPHLVRRGRGLILNLGSFSGQWSTPLLATYAGSKAFLIAWTQALGEEMRRSHVDVQLLNTYFVVSSMSKVRKPSMMVPTPKNFVRSALSRIGRSSGALGRPFTLTPFPSHAWLDWAVEHFVPRWWLLRQAYDVSLDTRRRAIRKAQRLEKSQ