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MFHAS1

Gene
MFHAS1
Protein
Malignant fibrous histiocytoma-amplified sequence 1
Organism
Homo sapiens
Length
1052 amino acids
Function
Probable GTP-binding protein (PubMed:24286120). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:26599367, PubMed:28471450, PubMed:28609714). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (PubMed:28609714). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway (PubMed:29168081). Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (PubMed:23327923).
Mass
116.95 kDa
Sequence
MAGMDSGNLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLSRLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRHLRRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDPSLLLHKLLLGTSGEGKAEGESSPPMARSTPSQELLRATQLHQYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPLGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPARGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ

Gene
Mfhas1
Protein
Malignant fibrous histiocytoma-amplified sequence 1 homolog
Organism
Mus musculus
Length
1048 amino acids
Function
Probable GTP-binding protein (By similarity). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways (PubMed:20616063, PubMed:26599367). Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (By similarity). Both inhibits and activates the TLR2-dependent signaling pathway (PubMed:26599367). Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype. It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway. Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway (By similarity).
Mass
116.599 kDa
Sequence
MAGQDSGNLKTVRLWRDAALRARKLRSNLRQLTLSCPGAGGDPLESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPRGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLGSKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCFPTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKNDAEGLSHLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPLQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRDASLLLHKLLLGTNGEGEGEGESFPTIAVPSPGQDPLRATQLHHYVEGFLLHGLLPAHIIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFAYRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTPTVISPCSKKNVGEKHRNQ

Gene
mfhas1
Protein
Malignant fibrous histiocytoma-amplified sequence 1 homolog
Organism
Xenopus tropicalis
Length
997 amino acids
Function
Probable GTP-binding protein. Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways.
Mass
113.096 kDa
Sequence
MAGNDTCNNSCDVKTARLWRDAALRSRKLRSSLRQLTLSCVDKRKLILPADLGDVEVLNLGNNSLEEVPDGLQSLSAGNLHVLILRRNKFLNVPTAVYHLGRLTELDISYNRLSCLTEAVGLLGKLKKLCLSHNQLRTLPRQLGMLVDLEELDVSFNQITHLPDTMQGLPSLRTLDLDHNELCSFPQQLFHVPALEELDFSGNKMLGSLPEGIRSMQSLKILWLSSTSLCLLPDSICELVNLESLMLDNNNLHTLPEGFGALQKLKMLNVSSNAFQDFPVPLLQLVDLEELYMSRNRLVVLPEVISCMTKLVTLWLDNNRIRYLPDSIVELSFLEELVLQGNQIAILPDDFGKLSKVNIWKIKDNPLIQPPYEVCMKGISYIAAYQKELAHSQPAVKPRLKLVLLGLKDAGKTLLRQCLTDEQNTSTLVQGYKGIEITNWTADAERGLAFIVYDLAGDQSYDIIKPFFFSPGALYILVVNLKSYVCKHFYTHVGYFIHLITSKVPHAVVCIVGTHIDLCNEKELEEKCLDIHHQIAVQEKRDSETLQTLIQTVDKALSQDFDFRASNPHSAFYGVSDKNLRRKKTHFQYLMNSRLQILSPVLCVSCLDFSNIKRLREKLLSVAEHREIFPNLHRVLPKSWQMLEELHFKPQELWLTWWDSARLGLQAGLTEDRMQSALSFLHESGKLLYFEDNQTLKEYVFHNLTKLIDILNVFFQRDASVLFAKLTSDATADETKVTQFHHYVEGFLLHGLLPTHIIRSLLKPHIKTHQDLQLILELLEKMGLCYCINKPKNKLLNGATVWYKFPCYVKNEAPHAEAWINGTNISEPCLAVEQLQIEYSFPFIFPPGLFARFSVQINSHIVHRSDSKFQIFAYRGKVPVVVSFQPARGALQPGILSIASHASLPNIWTAWQAITPLVEELNALLQEWPSLYYTVHVLCSKCLKRGSPNPHPFPGELLSQPRPDGVTELICPKNGSERLNVSLVYPPTPTMISPCSK