MET4

DNA (cytosine-5)-methyltransferase 4

1519 amino acids

Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

171.586 kDa

MEMETKAGKQKKRSVDSDDDVSKERRPKRAAACTNFKEKSLRISDKSETVEAKKEQILAEEIVAIQLTSSLESNDDPRPNRRLTDFVLHDSEGVPQPVEMLELGDIFIEGVVLPLGDEKKEEKGVRFQSFGRVENWNISGYEDGSPVIWISTALADYDCRKPSKKYKKLYDYFFEKACACVEVFKSLSKNPDTSLDELLAAVSRSMSGSKIFSSGGAIQEFVISQGEFIYNQLAGLDETAKNHETCFVENRVLVSLRDHESNKIHKALSNVALRIDESKVVTSDHLVDGAEDEDVKYAKLIQEEEYRKSMERSRNKRSSTTSGGSSRFYIKISEDEIADDYPLPSYYKNTKEETDELVLFEAGYEVDTRDLPCRTLHNWTLYNSDSRMISLEVLPMRPCAEIDVTVFGSGVVAEDDGSGFCLDDSESSTSTQSNDHDGMNIFLSQIKEWMIEFGAEMIFVTLRTDMAWYRLGKPSKQYAPWFGTVMKTVRVGISIFNMLMRESRVAKLSYANVIKRLCGLEENDKAYISSKLLDVERYVVVHGQIILQLFEEYPDKDIKRCPFVTSLASKMQDIHHTKWIIKKKKKILQKGKNLNPRAGIAPVVSRMKAMQATTTRLVNRIWGEFYSIYSPEVPSEAINAENVEEEELEEVEEEDENEEDDPEENELEAVEIQNSPTPKKIKGISEDMEIKWDGEILGKTSAGEPLYGRAFVGGDVVVVGSAVILEVDDQDDTQLICFVEFMFESSNHSKMLHGKLLQRGSETVLGMAANERELFLTNECLTVQLKDIKGTVSLEIRSRLWGHQYRKENIDVDKLDRARAEERKTNGLPTDYYCKSLYSPERGGFFSLPRNDMGLGSGFCSSCKIRENEEERSKTKLNDSKTGFLSNGIEYHNGDFVYVLPNYITKDGLKKGSRRTTLKCGRNVGLKAFVVCQLLDVIVLEESRKASKASFQVKLTRFYRPEDISEEKAYASDIQELYYSQDTYILPPEAIQGKCEVRKKSDMPLCREYPILDHIFFCEVFYDSSTGYLKQFPANMKLKFSTIKDETLLREKKGKGVETGTSSGMLMKPDEVPKEKPLATLDIFAGCGGLSHGLENAGVSTTKWAIEYEEPAGHAFKQNHPEATVFVDNCNVILRAIMEKCGDVDDCVSTVEAAELAAKLDENQKSTLPLPGQVDFINGGPPCQGFSGMNRFSHGSWSKVQCEMILAFLSFADYFRPKYFLLENVKKFVTYNKGRTFQLTMASLLEMGYQVRFGILEAGTYGVSQPRKRVIIWAASPEEVLPEWPEPMHVFDNPGSKISLPRGLRYDAGCNTKFGAPFRSITVRDTIGDLPPVENGESKINKEYGTTPASWFQKKIRGNMSVLTDHICKGLNELNLIRCKKIPKRPGADWRDLPDENVTLSNGLVEKLRPLALSKTAKNHNEWKGLYGRLDWQGNLPISITDPQPMGKVGMCFHPEQDRIITVRECARSQGFPDSYEFSGTTKHKHRQIGNAVPPPLAFALGRKLKEALYLKSSLQHQS

MET4

Transcriptional activator of sulfur metabolism MET4

672 amino acids

Positive trans-acting factor capable of stimulating the transcription of the MET genes from the methionine biosynthetic pathway. MET4, MET28 and CBF1 are required for full induction of MET25 and MET16 gene transcription. MET4 controls as well the derepression of MET6. Required for the transcription of genes necessary for sulfur amino acid biosynthesis. Involved in the transcription activation of MET28 and MET30. Required for MET3 gene expression via assembly of the MET4-MET28-MET31 and MET4-MET28-MET32 complexes. Involved in response to cadmium and arsenic. Cadmium-activated MET4 also induces glutathione biosynthesis.

Belongs to the bZIP family.

74.373 kDa

MKQEQSHEGDSYSTEFINLFGKDTATHPSSNNGANNNGMGSTNSLDQFVATASSSSSLVTSSENRRPLIGDVTNRGNTNLYDHAVTPEILLEQLAYVDNFIPSLDNEFSNVDWNVNTTHNNANNNGADTFSSINANPFDLDEQLAIELSAFADDSFIFPDEDKPSNNNNNSNNGNDDHSNHDVLHEDPSTNNRQRNPHFLTQRRNTFLTSQYDQSKSRFSSKNKRNGNNGETNNFGDNMQNNHPFEPNFMGSPSQFPADATNMTSIDHGGFTNVDITSTENNTTGDNGVDALSNLLHRTTHTPNRSSPLSNVTSAQNSSSQQRKHSESKVDSNSDNNSSNKAPNITVPDYSIIPTSVLVTLLPRVNVPNGAYNSLISAGFDNDQIDAIAAIMAYHHQKKIRENNSNNNKNINTNDSQEAPILKNINELLSVLIPPSPAETRGPTTLSTSPSFNEHGVVAEASFLSSILELGIKHPKSNNIHNQRQPSRNDHKISRESDGNNGNDNVHHNNAVIKSSTTRGDEIAKIRSEPTLNASSSDHKENSLKRSHSGDLKNKKVPVDRKYSDNEDDEYDDADLHGFEKKQLIKKELGDDDEDLLIQSKKSHQKKKLKEKELESSIHELTEIAASLQKRIHTLETENKLLKNLVLSSGETEGIKKAESLKKQIFEKVQKE

MET4

Transcriptional activator of sulfur metabolism MET4

672 amino acids

Positive trans-acting factor capable of stimulating the transcription of the MET genes from the methionine biosynthetic pathway. MET4, MET28 and CBF1 are required for full induction of MET25 and MET16 gene transcription. MET4 controls as well the derepression of MET6. Required for the transcription of genes necessary for sulfur amino acid biosynthesis. Involved in the transcription activation of MET28 and MET30. Required for MET3 gene expression via assembly of the MET4-MET28-MET31 and MET4-MET28-MET32 complexes. Involved in response to cadmium and arsenic. Cadmium-activated MET4 also induces glutathione biosynthesis.

Belongs to the bZIP family.

74.373 kDa

MKQEQSHEGDSYSTEFINLFGKDTATHPSSNNGANNNGMGSTNSLDQFVATASSSSSLVTSSENRRPLIGDVTNRGNTNLYDHAVTPEILLEQLAYVDNFIPSLDNEFSNVDWNVNTTHNNANNNGADTFSSINANPFDLDEQLAIELSAFADDSFIFPDEDKPSNNNNNSNNGNDDHSNHDVLHEDPSTNNRQRNPHFLTQRRNTFLTSQYDQSKSRFSSKNKRNGNNGETNNFGDNMQNNHPFEPNFMGSPSQFPADATNMTSIDHGGFTNVDITSTENNTTGDNGVDALSNLLHRTTHTPNRSSPLSNVTSAQNSSSQQRKHSESKVDSNSDNNSSNKAPNITVPDYSIIPTSVLVTLLPRVNVPNGAYNSLISAGFDNDQIDAIAAIMAYHHQKKIRENNSNNNKNINTNDSQEAPILKNINELLSVLIPPSPAETRGPTTLSTSPSFNEHGVVAEASFLSSILELGIKHPKSNNIHNQRQPSRNDHKISRESDGNNGNDNVHHNNAVIKSSTTRGDEIAKIRSEPTLNASSSDHKENSLKRSHSGDLKNKKVPVDRKYSDNEDDEYDDADLHGFEKKQLIKKELGDDDEDLLIQSKKSHQKKKLKEKELESSIHELTEIAASLQKRIHTLETENKLLKNLVLSSGETEGIKKAESLKKQIFEKVQKE