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MEMO1

Gene
memo1
Protein
Protein MEMO1
Organism
Danio rerio
Length
297 amino acids
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling (By similarity).
Similarity
Belongs to the MEMO1 family.
Mass
33.403 kDa
Sequence
MSNRMVCREASHAGSWYTASGSQLNAQLEGWLSQAQSIAGPARAIIAPHAGYTYCGACAAHAYKQVDPSITRRVFILGPSHHVPLSRCALSPAEVYRTPLYDLRIDQKVYADLWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMENHKDEFSIVPVLVGALSGSKEQEYGKLLSKYLADPSNLFIISPDFCHWGQRFRYTYYDESQGEIYRSIEHLDKMGMGIIEQLDPISFSNYLKKYHNTICGRHPIGVLLNAVAELKKNGIDMNFSFLNYAQSSQCRNWSDSSVSYAAGALIVH

Gene
MEMO1
Protein
Protein MEMO1
Organism
Homo sapiens
Length
297 amino acids
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Similarity
Belongs to the MEMO1 family.
Mass
33.733 kDa
Sequence
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH

Gene
MEMO1
Protein
Protein MEMO1
Organism
Macaca fascicularis
Length
297 amino acids
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Similarity
Belongs to the MEMO1 family.
Mass
33.733 kDa
Sequence
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH

Gene
Memo1
Protein
Protein MEMO1
Organism
Mus musculus
Length
297 amino acids
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Similarity
Belongs to the MEMO1 family.
Mass
33.692 kDa
Sequence
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSVTRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRSWQDSSVSYAAGALTVH

Gene
Memo1
Protein
Protein MEMO1
Organism
Rattus norvegicus
Length
297 amino acids
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Similarity
Belongs to the MEMO1 family.
Mass
33.679 kDa
Sequence
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKSGMNMSFSFLNYAQSSQCRSWQDSSVSYAAGALTVH

Gene
memo1
Protein
Protein MEMO1
Organism
Xenopus laevis
Length
297 amino acids
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling (By similarity).
Similarity
Belongs to the MEMO1 family.
Mass
33.422 kDa
Sequence
MSNRSVCREASHAGSWYSASGSQLSAQLDGWLSQAQTSKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSVTRRVFILGPSHHVALSRCALSTVDIYRTPLYDLHVDQKVYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDDLTIVPVLVGALSESKEQEFGKVFSKYLADPTNLFVISSDFCHWGQRFRYTYYDESQGEIYRSIENLDKMGMSIIEQLDPVQFSNYLKKYHNTICGRHPIGVLLNAATELQKNGVNMSFSFLNYAQSSQCRSWQDSSVSYAAGALVVH

Gene
memo1
Protein
Protein MEMO1
Organism
Xenopus tropicalis
Length
297 amino acids
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling (By similarity).
Similarity
Belongs to the MEMO1 family.
Mass
33.448 kDa
Sequence
MSNRALCREASHAGSWYTASGSQLSAQLDGWLSQAQTSKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSVTRRVFILGPSHHVALSRCALSTVDIYRTPLYDLHIDQKVYGDLWKTGMFERMSLQTDEDEHSIEMHLPYTAKTMESHKDDLTIVPVLVGALSESKEQEFGKLFSKYLADPTNLFVISSDFCHWGQRFRYTYYDESQGEIYRSIENLDKMGMGIIEQLDPVQFSNYLKKYHNTICGRHPIGVLLNAATELQKNGVNMSFSFLNYAQSSQCRSWQDSSVSYAAGALVVH

Gene
memo1
Protein
Protein MEMO1 homolog
Organism
Dictyostelium discoideum
Length
290 amino acids
Similarity
Belongs to the MEMO1 family.
Mass
33.37 kDa
Sequence
MIRNCTHAGSWYLDNARKLEKQLSDWLSEASRQNQNVKSIIAPHAGYSYSGRAAAYAYINLIPENYKRVFILGPSHHVYMKTCGLTKLDTWETPIGNLKVDKDTTNKLFDTGSFIWNTKSVDEDEHSLELQLPYIAKVAEKRLLELSIVPIMVGSLSIDLEELYGKILAPYFDDPENFFVISSDFCHWGERFGYTRYENKEVPIYKYIEELDRKGMEIIESGDPVQFSKYLKETKNTICGRCPIAVMLWITKNSQFKYNISSLYYEQSSKVIKSSDSSVSYGVLSFTKEN

Gene
MEMO1
Protein
Protein MEMO1
Organism
Bos taurus
Length
285 amino acids
Function
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Similarity
Belongs to the MEMO1 family.
Mass
32.525 kDa
Sequence
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLAEPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFFQQASWRRRMGAAAV