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MEIOB

Gene
MEIOB
Protein
Meiosis-specific with OB domain-containing protein
Organism
Macaca fascicularis
Length
471 amino acids
Function
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).
Similarity
Belongs to the MEIOB family.
Mass
52.93 kDa
Sequence
MANSFATRTFTTLSDLQPNMANLKVIGVVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPAHFVNAASWGNEDYIKSLSDSFRVGDCVIIENPLIQRKEIEREEKFSPATPSNCKLLLSENHSTVKVCSSYEVDTKLLSLIHLPVKESHDYYSLGDIVANGHSLNGRIINVLAAVKSVGEPKYFTTSDRRKGQRCEVRLYDETEFSFAMTCWDNESILLAQSWMPRETVIFVSDVRISFDKFRNCMTATVISKTIITTNPETPEANILLNFIRENKETNVLDDEIESYFKESINLSTIVDVYTVEQLKGKALKNEGKADPSYGILYAYISTLNIDDETTKVVRNRCSTCGYIVNEASNMCTICNKNSLDFKSVFLSFDMLIDLTDHTGTLHSCSLTGSVAEETLGCTVNEFLAMTDEQKTALKWQFLLERSKIYLKFVVSHRARSGLKISVLSCKLADPTEASRNLSGQTRV

Gene
Meiob
Protein
Meiosis-specific with OB domain-containing protein
Organism
Mus musculus
Length
470 amino acids
Function
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro.
Similarity
Belongs to the MEIOB family.
Mass
52.975 kDa
Sequence
MAKFFALKNFTALSDLHPNMANLKIIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPCHFVNVSSWGSEDYIRSLSESFRVAECVIIENPLIQRKDTEREEKFSPATPSNYKLLLSENHSMVKVCSPYEVDTKLLSLIHLPVKESRDYYSLADIVANGHSLDGRIINVLAAVRSVGEPKYFTTSDRRKGQRCEVKLFDETEPSFTMTCWDNESILLAQSWMARETVIFASDVRINFNKFQNCMAATVISKTIITVNPDTPEANILLNYIRENKETNVADEIDSYLKESVNLNTIVDVYTVEQLKVKALKSEGKADPFYGILYAYISTLNIDDETTKVVRNRCSSCGYIVNEASNTCTICNQDSSRLKSFFLSFDVLVDLTDHTGTLHSCSLSGSIAEETLGCTINEFLTMTSEQKTKLKWQLLLERSKIYLKLILSHRARGGLKVTILSCKLADPTEASRNLARQGHT

Gene
Meiob
Protein
Meiosis-specific with OB domain-containing protein
Organism
Rattus norvegicus
Length
470 amino acids
Function
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).
Similarity
Belongs to the MEIOB family.
Mass
52.819 kDa
Sequence
MAKFFALKNFTALSDLHPNMANLKIIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPNHFVNVSSWGSEDYIRSLSDNFKVGECVIIENPLIQRKETEREERFSPATPSNYKLLLSENHSMVKVCSPYEVDTKLLSLIHLPVKESRDYYSLADIVANGHSLDGRIINVLAAVRSVGEPKYFTTSDRRKGQRCEVKLFDETEPSFTMTCWDNESILLAQSWMARETVIFASDVRINFNKFQNCMAATVISKTIITVNPDTPEANILLNFIRENKETSIADEIDSYLKESVNLNTIVNVYTVEQLKGKALENEGKVDPFYGILYAYISTLNIDDETTKVVRNRCSSCGYIVNDASNTCTICSKDSSRSRSFCLSFDVLVDLTDHTGTLRSCSLSGSVAEETLGCTINEFLTMTSEQKTKLKWQLLLERSKIYLKLILSHRARGGLKVTILSCKLADPIEASRDLAGQGHT

Gene
MEIOB
Protein
Meiosis-specific with OB domain-containing protein
Organism
Homo sapiens
Length
442 amino acids
Function
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).
Similarity
Belongs to the MEIOB family.
Mass
49.313 kDa
Sequence
MANSFAARIFTTLSDLQTNMANLKVIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPAHFVNAASWGNEDYIKSLSDSFRVGDCVIIENPLIQRKEIEREEKFSPATPSNCKLLLSENHSTVKVCSSYEVDTKLLSLIHLPVKESHDYYSLGDIVANGHSLNGRIINVLAAVKSVGEPKYFTTSDRRKGQRCEVRLYDETESSFAMTCWDNESILLAQSWMPRETVIFASDVRINFDKFRNCMTATVISKTIITTNPDIPEANILLNFIRENKETNVLDDEIDSYFKESINLSTIVDVYTVEQLKGKALKNEGKADPSYGILYAYISTLNIDDETTKVVRNRCSSCGYIVNEASNMCTTCNKNSLDFKSVFLSFHVLIDLTDHTGTLHSCSLTGSVAEETLGCTFVLSHRARSGLKISVLSCKLADPTEASRNLSGQKHV