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MED6

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
357 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
38.313 kDa
Sequence
MAQQVEEIEQDLSHIHWSWPEAIAANPARSLATPDLAMDYFAYSPFWDAKSNNNVLRTQRRIENPAYGHAEEKVELNAFMSGFEYVVAHSQPPDLFVIHRREVESSGKRDRVTGAWFILHEKIYQCPTLFDVMSTRLKNATSLISKTLSTLSENRPPANPRTTTLWRSIPSVTSNQPDGTQPSSLDQAEKPDEGKKDDSLNGSSPLDGSDGKASPAGPDWHLFHALQATRASLVSLETLAKTPTQTTDPREELNNIEIAMDNQFGGQNQSLSGKGPNVKGGAAAVKNISVPFVPKHSAGHATSTTGLTPSIWGGSASLGVSTAAVPAREAGGSPLKWPGGDKSAPIAGATLAGQTGR

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
357 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
38.313 kDa
Sequence
MAQQVEEIEQDLSHIHWSWPEAIAANPARSLATPDLAMDYFAYSPFWDAKSNNNVLRTQRRIENPAYGHAEEKVELNAFMSGFEYVVAHSQPPDLFVIHRREVESSGKRDRVTGAWFILHEKIYQCPTLFDVMSTRLKNATSLISKTLSTLSENRPPANPRTTTLWRSIPSVTSNQPDGTQPSSLDQAEKPDEGKKDDSLNGSSPLDGSDGKASPAGPDWHLFHALQATRASLVSLETLAKTPTQTTDPREELNNIEIAMDNQFGGQNQSLSGKGPNVKGGAAAVKNISVPFVPKHSAGHATSTTGLTPSIWGGSASLGVSTAAVPAREAGGSPLKWPGGDKSAPIAGATLAGQTGR

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Coccidioides immitis (strain RS)
Length
353 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
37.79 kDa
Sequence
MEPSPDVPLEEITWHSPQHVQMMGGFLHSNNILFYFAESPFFDPTSNNASLALQAMHNENLRPFIETRGAFEGRLKTMQGLEFIVAHDPLLEAAAANAAAVARGEQPKEASNVWVIRKQMRRRSAAMGGQDDVQVLATYFVVGDSVFMAPSVWSVVGRRMLSTVTSLTKVLSTASALLTFSPSYGHSYLPHVPKSLEPTQLGQQSAQQSKETTPMPDMSGDKTTSRSALADASTTTLNASALQDARDFAETLNLLARYGNEYIDETPLAGEPGSFIFTKASASAAEQLSVAGAGAQASRQNIRSGATTPVPFGAGRPASVQPDSTKGKAADRPPAATKDKGKKRKSKIGSMSQ

Gene
med6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
328 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
35.315 kDa
Sequence
MASAQDGSMEEILWRSPAHVQMMGGFLHSNNILFYFAESPFFDATSNNASLAIQANYNETLRHFVETREAFEGRLKTMQGLEFVVAYDPLQAAAQTETSFAHEPSNIWVIRKQTRRKRAGLEDEVVVLSTYFVVGDCIYMAPSVASVVGNRLLSAVTSLTSLLKTASSLPSFTPSHGHTYLPPAPKPTDSSQPGAQSQQSKENTPMPDADSTKALLVGPQTANAGAILQDTRTFAESFSLLARYGEEFMDENPLVGEPGSFILSKSGDTDRGAASKQPSNVNRPGSIPGKVGTPQVKVDTPGKTPEKGATPSASDDSKIRKKKAKIGN

Gene
med6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
325 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
35.151 kDa
Sequence
MAGTQDPSSLEEILWRSPSHVQMMGGYLHSNNILFYFAESPFFDATSNNASLAIQANYNEAFRHFVETREAFEARLKTMQGLEFMVAYDPLQAAAGANAQFVHEPSNVWVIRKQTRRKRSGFEDEVVVLATFFVVGDCIYMAPSAASVIGNRILSAVTSLTSLLKTASTLPKFTPSHGHTYLPPAPKSTDVSHPSVQSQTSKENTPMPDADATNKSQSFTGSQNSSGPAVYDMRSLAESFSLVARYGDEFMDESPLMGEPGSFILSRPGDADRGAAPKQSQPSSTNAGGRVGTPLAKVDTPGKLSDKNSAAEEPKLRKKKSKPAS

Gene
med6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
324 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
35.128 kDa
Sequence
MAGPQDASLEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDATSNNASLAIQANYNEAFRHFVETREAFEGRLRTMQGLEFVVAYDPLQAAAQTDTQFAHEPSNVWVIRKQMRRKRAGQEDEVVVLATFFVVGDCIYMAPSVASVVGNRILSAVTSLTSLLKTASTLPIFTPAHGHTYLPPAPKPADAGQPGVPSQQSKENTPMPDAENPARVPLVGSQAGNTASTFQDTRTLAESLHLFLRYEDEYMDENPLVGEPGSFIMSKANDVDRTATAKQPQSTIPTKMGAPLVRVDTPGKGPEKVGTPSSSDESSLKKKKGGVGG

Gene
med6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Length
324 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
35.034 kDa
Sequence
MAGTQDAPLEEILWRSPSHVQMMGGFLHSNNILFYFAESPFFDATSNNASLAIQANYNETFRHFVETREAFEGRLKTMQGLEFVVSYDPLQAAAQSNGQFAHEPSNIWVIHKQTRRKRPGLEDEVEVLSTFFVVGDCIYMAPSVASVVGNRILSAVTSLTNLMKTAASLPNFTPAHGHTYMPPVSKSTDTAQPSAQPSKENTPMPDADSTKASLVGGAQSTNAGSVFQHTRTLAESFSLLTQYGDEFMDENPLVGEPGSFIMSRNNEGAASKQPPVGTTRPGTVPVRAGTPQVKVDTPGKTPDKGLTPGPDENKLRKKKGKSGV

Gene
med6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
323 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
35.016 kDa
Sequence
MAGTPDASMEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDPTSNNASLAIQANYNEAFRHFVETREAFEGRLKTMQGLEFVVSYDPIQAAAQPDGRFAHEPSNIWVIRKQNRRKRTGLDDEVAVLSTYFIVGDCIYMAPSVASVVGNRILSAVTSLTSLLKTASTLPTFTPSHGHTYMPPALKQADASQPGTQSQQSKENTPLPDADAAGKASLVGSSQMVGAGSSLQDTRTLAESFNLLRRYGDEFMDEHPLVGEPGSFILSRVNDTDRTSAAKPPATAAKVGTPQVRVDTPGKVSEKGATPSGSEENKMRKKKTKVGS

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
302 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
33.218 kDa
Sequence
MDTPLDELQWKSPEWIQAFGLRTDNVLDYFAESPFFDKTANNHVIKMQRQFSQLPNNGAAAGSMNPETMRDAHSEDMGQEQEFSYVDPIRRAILEKYVVHAFLERELMKVRGIEYVLANVREPDFWVIKKQRRTSPTAIEPLQTYYIVGANVYQSPTVFKIVQSRLLACSSHLSATLAELNNLVEFKPSQGVQYKNILDMPVTTRKTGNTANVGSVPGTISASLNMPMVNTGRLNSAGAATIGTSGVPNSAGMTGANTMATGQTGATSRFENGSSRSSTDAISTDTLDKLLITSMKSTPEYI

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Arabidopsis thaliana
Length
298 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
33.411 kDa
Sequence
MDSSLLSAATADTFNGNAADQIPPPLQPPGTDMTGISFRDQLWINSYPLDRNYIFDYFALSPFYDTTCNNEILRRRSIHPLDLSHLSKMTGLEYMLTDATEPNLFVFRKQKRDGPEKVTPMLTYYILDGSIYQAPQLCSVFAARVSRTIYNISKAFTDAASKLETIRQDLQVCLVAIVLSLSVNLGSYFLLIFKLMANGEQVYGFNKFLFDTENQNEPAESKPASETVDLKEMKRVDVILTSLYRKLAPPPPPPPFPEGYVSQEALGEKEELGTQGGESQPPQVDPIIDQGPAKRMKF

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
295 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
32.819 kDa
Sequence
MNVTPLDELQWKSPEWIQVFGLRTENVLDYFAESPFFDKTSNNQVIKMQRQFSQLNDPNAAVNMTQNIMTLPDGKNGNLEEEFAYVDPARRQILFKYPMYMQLEEELMKLDGTEYVLSSVREPDFWVIRKQRRTNNSGVGSAKGPEIIPLQDYYIIGANIYQSPTIFKIVQSRLMSTSYHLNSTLESLYDLIEFQPSQGVHYKVPTDTSTTATAATNGNNAGGGSNKSSVRPTGGANMATVPSTTNVNMTVNTMGTGGQTIDNGTGRTGNGNMGITTEMLDKLMVTSIRSTPNYI

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
268 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
29.472 kDa
Sequence
MSLPPLDELQWKSPEWIQTFGLHTDNVLDYFSESPFFDKTSNNQVVKMQQQFSQQSQVPGSMPLGSSSGIGAAAGAGTVSPSDRSLIWERYPVHAMLEKELMKMKGIEYILVLVREPDLWIIRKQQRDGPTKTTTLRDYYVIGSAVYQSPTVYKIIQNRLLSTNYHLSHSLSQLNKLVEFHPAQGASFLRPEDPLCSSVAAATTSGSTASHTVASSVSVPETGPINAETSGATAAATSIDPDRRQDSFNTEIMDKLMATSIKANPVYI

Gene
med6
Protein
Putative mediator of RNA polymerase II transcription subunit 6
Organism
Dictyostelium discoideum
Length
267 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
30.946 kDa
Sequence
MEDFNNDDPMNFDKDDMINNNNDNNNNNNDNDNNNENNEDSNNNSNLENMISDTSTPRILEEEPDLTQVMWRDPLWLQMYPLNPQTILQYFSYSQFYDKNCNNEQLKMQRLDLSALKNMDGLEYELIKFVEPSFFLIAKQTRISPTDVLINTLYYVINGNIYQAPELHVVFKSRVSQSISHLSEAFNSISSIVNWDIVNGYSLNLDPSNQQEKSKLAAYSRKQIEDTKRLDQLINSLFIKFPAINRPVENPQQMGGGITPQQQPSQP

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Anopheles gambiae
Length
267 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
29.8 kDa
Sequence
MNPGRLGLAPLLQENPLWISWHDSNWIPVLNPGNVMDYFSEKSNPFYDRTCNNEIVRMQRQSLELLNNMTGVEYIPLHVQDPILYVIRKQHRHSPTEATPMADYYIIAGTVYQAPDLASVFNSRILSTVHHLQTAFDEASSYSRYHPSKGYSWDFSSNKAIAEKTKTQTKKEAPVKEEPSSIFQRQRVDMLLGDLLRKFPLPLPQMTNNPTGGNPSDTANASNNHGGAAGDSDHVGADATLIKQEPTEGGVGRAGNNDVPPEKKMKL

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
263 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
29.219 kDa
Sequence
MESLDEIQWKSPEFIQERGLNTNNVLEYFSLSPFYDRTSNNQVLMMQFQYQQIQIPPGVSFHQYFQSRLSEMTGIEFVIAYTKEPDFWIIRKQKRQDPQNTVTLQDYYIIGANVYQAPRIYDVLSSRLLASVLSIKNSTDLLNDMTSYHISDGGHSYINSIHGSSSKPSQSSAVSKPSSTNTGTNATTTPITLTTPSGATVPSTVSNGISTSTEIASGVFDTLLNDVVMNDDHLYIDEIPLYGEGSTLERLGLKGNKDAGLSL

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
263 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
29.149 kDa
Sequence
MSGEALDEIQWKSPEFIQERGLHTGNVLEYFSLSPFYDRTSNNQQLMMQFQFQQIQIPVNTTFQQFFQEKLREMTGVVFVIAYNREPDFWIIRKQLQLDPQNAVTLQDYYIIGANVYQAPKVYDVLSSRLLSSVLQLRNSIDLLNKMTQFHVSDGGHSYNNAIHQSTSNPTQGQSSGKSISATVGNTGTTATPMTMQTPQTVGPNGPATVQSGANSAAAISKNGSTSSAESADDRKNIYLDDIPLYGRGSTVEMLGLKVNLES

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
257 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
29.035 kDa
Sequence
MSKEPLDEIQWKNPEWIQQFGLFTGNVLDYFSESPFYDRTSNNQVLRMQFQFQQIPPNINPQKYLQSKLVEMTGIEFIIAASREPDFWIIRKQTRLSPKQVNIEQDYYIIGANIYQAPKVYDILSSRLLSSVLSIKGSMELLNKMSKFNIHDMGHSYPTLQAEKEISSSSNTIPNTVSVNTTTPMLHTPATASNINSNGHSSTNLGLNNEISNLAFDNLLNNVINSSNDDTYLEDIPLYGKGSTVESLGVKVNLDDV

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
254 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
28.687 kDa
Sequence
MSTQPAPPPEAPSNLLHVQFKNPEFLSYLSHLQSTGQVSLGRDSSCAKFDPAHPLTEHNVMAYFATSPFFDRRSNNEQIRMQNIANGIQNLSGGMGAKQEEQELKRFTGLEFVLVHSREPTCFVVQKRWRTSPTETTPLAAYYVINDSIYQAPDLYSILATRLQSTVYALRMSLSTQRRARPSFDPRRGHHGRFIVADAPTSIDADSNRTCTTQSTHTHHADDHTPQLEHQQDHIHPPPPAAFTQPQLKKARFD

Gene
med6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Danio rerio
Length
254 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
29.25 kDa
Sequence
MATVDLRDNLLGISWVDSGWVPILNPSNVLEYFSERSNPFYDRTCNNEVVKMQRSTLDHLTQLVGVEYILLHTQEPILYIIRKQQRQSPTQVIPLADYYIIAGVVYQAPDLGSVISSRALSAVHGIQSAFDEAMSFCRYHPSKGYWWHFKDQEEKERVKPKSKRKEEPSSLFQRQRVDTLLLDLRNKFPPTFYQTKPGEKPVPVEVKKEPEVPVETVKPQEERETKPPAPPAPPRPPPQTTPNKPPPEKRARVQ

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Drosophila melanogaster
Length
249 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
28.374 kDa
Sequence
MASRQMTNDHLRLSWHDTQMMATLSPQTVMDYFCRKSNPFYDHMCNNETVRMQRLGPEHLHNMIGLEYILLHVAEPILYVIRKQHRHNPSEATPIADYYIIGGTVYKAPDLANVINSRILNTVVNLQSAFEEASSYARYHPNKGYTWDFSSNKVFSDRSKSDKKDANSAKDENSGTLFQKQRVDMLLAELLRKFPPPIPPMLQNLQQPPPAGDDLNTARNASEMNNATGPLDIKTEGVDMKPPPEKKSK

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Homo sapiens
Length
246 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
28.425 kDa
Sequence
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ

Gene
Med6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Mus musculus
Length
246 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
28.434 kDa
Sequence
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQEKVKPKAKRKEEPSSIFQRQRVDALLIDLRQKFPPRFVQQKSGEKPVPVDQAKKEAEPLPETVKSEEKESTKNIQQTVSTKGPPEKRMRLQ

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Pongo abelii
Length
246 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
28.425 kDa
Sequence
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKEHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPVPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Bos taurus
Length
246 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
28.406 kDa
Sequence
MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGVEYILLHAQEPILFIIRKQQRQSPTQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVKPKVKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQQKSGEKPVPVDQTKKEAEPLPETVKSEEKETAKNVQQTVGTKGPPEKRMRLQ

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
235 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
26.05 kDa
Sequence
MSQPPLDELQWKSPEWIQSFGLRTDNVLDYFSQSPFFDKTSNNHVVKMQQQFSQQMPPAPQTARPKAAPSAERQAIWDRYPAYALLEQELAKLKGIEYVLAHVREPDFWVVRKQRRAGDRVTALNDYYIIGANVYQAPTAYSVVQNRLLSTGFHLSAALGAIQRLARFQPGQGAAFVPVEQNSVQPASGTTASSATAPALTAALDGATAGYSDVLTPEMMDRLMLQSLKSTPLYL

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
227 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
25.704 kDa
Sequence
MENLDEVQWRSPEWIQAHQGLRTDNVLDYFAESPFYDRVSNNQVLRMQTQFNQQQTGQLTPQHFEQELQKMTGIEFVITHVREPDLWVIKKQNRLNPQQTTPISTYFVINENVYMAPTVAAIMQSRVLSTSMFLKRALEEAIELPSYSPSQGYTYEDSQLTTAGDDDSTPQASKAELGLLERSFRAAISGQQKYVSDIAPISSQSESAASSVPGTPVLKGRKLPLKK

Gene
med6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
216 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
24.906 kDa
Sequence
MASGAPPSVDLTSIQWRMPEWVQSMGGLRTENVLEYFSQSPFYSHKSNNEMLKMQSQFNALDLGDLNSQLKRLTGIQFVIIHERPPFLWVIQKQNRLNENEVKPLTVYFVCNENIYMAPNAYTLLATRMLNATYCFQKALTKIEKFPQYNPQEGYTYPKLSNDNLEVDHSNTNEPADENKNQSIENADYSFSPEDFSVVRAFMQSLHSSKEAPDVK

Gene
MED6
Protein
Mediator of RNA polymerase II transcription subunit 6
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
177 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 6 family.
Mass
20.879 kDa
Sequence
MEEREESISFVDQRFLGSKPLDDTNVLEYFSGSPFYDKSCNNEILKMQTQFRGLDQKSKLFSMVGIFYEVESSNHEKTLFVIRKAYNHGDTAETLGMYYIIHGHVYAAPTNYSIYRCRMGDSMWQLNSFIDRMMEKRRFNPFSPPKGRRLAKSLEDSKDLDFMMEIFNDFKKEQAES