About Products Protein Database Contact

MED4

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Arabidopsis thaliana
Length
426 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
46.156 kDa
Sequence
MLQHQIVQSPARLGLTGPGSPSVQNPTPTRHGHPTSSSSSQSQHQQIQQQPNLLPSSTVAAASSASASAAVSSSALLSLLPPLPRAQALLQQMAVLTSKLFDVSPNRAIWLSAFRGSLPSFLSSHSLPPPPPLENPSPSSTKEILSQFNSLQTQLFEAVTELQEILDLQDAKQKVAREIKSKDSSLLAFANKLKDAERVLDMLVDDYSDYRKPKRSKIEEDDEDNDNESSSSSTTVSSQLKLKDILAYAHKISYTTFAPPEFGAGQAPLRGALPPAPQDEQMRASQLYTFADLDIGLPKTVENMEKKVEALIEPPPPPEAMDISAIHNLLPPNIAVPSGWKPGMPVELPRDLPLPPPGWKPGDPVVLPPLESIAAPRAEDHQHMRPSQGLHRPPDVIQVRAVQLDILEDDDSSDYSSDDASSDDED

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)
Length
351 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
39.082 kDa
Sequence
METNLDGCFERVEKTLGSMIDSLAKNNPSQKLAEELLAAEAELSKSLKLLETHQNNNARLQQLRQETSLHDTQLKDIMSSLWNMRRELKAVPTTSNPPPGPKHQFTTSELLAYARRISRNTLPLPGVTNGVDMTPTQFSASLTEPEDSFRLQFQPTQTQTPTNSFNLSFNGTVSTPIGLSAPTPTTTNDTQPSTQLPPSQQPPPKTAPADDKLPAHLKPAVNPLHDAAFHPWPTEGQIRTGALAALQRLVDAGIEPRGYDPAEQERRRVAEEKARREAEERARLEREEAERKGREERERMAREREAARLRNAGGADGDGERRESVAVARPKPKQFTFLGADDDEDDEDEDD

Gene
med4
Protein
Putative mediator of RNA polymerase II transcription subunit 4
Organism
Dictyostelium discoideum
Length
343 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
38.449 kDa
Sequence
MNKRINEVSGRPIGEYLSRDISDFQRVSRTLFECFSSLATGATLNSQQLQQIQLPIDQISNNATPNMVLQLMNHLIDVDKIYQNTLKKLEKHQKIQKEITEIQKEIEEKDKLISTLALNLKDIESFLENELSQDNVNINNGNASDGIVNEVLIDLKQPDDAASMDNIVNREVSPEDLISYAHKISGTTSAPFGYQPNAPLASLFKPPAPQDEMMRSSVLFTKPPPHVLKYYGLAEIDVTTPTMAANISSPFSIGGNVGDVTTPTSKEQEDQQQQQQQQQPQQQLSQSQQSQQQTESELQPIQSILQPPQQLNIDLDLNPDLDSSGDDDDEDDDDEESEEVEWD

Gene
med4
Protein
Putative mediator of RNA polymerase II transcription subunit 4
Organism
Dictyostelium discoideum
Length
343 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
38.449 kDa
Sequence
MNKRINEVSGRPIGEYLSRDISDFQRVSRTLFECFSSLATGATLNSQQLQQIQLPIDQISNNATPNMVLQLMNHLIDVDKIYQNTLKKLEKHQKIQKEITEIQKEIEEKDKLISTLALNLKDIESFLENELSQDNVNINNGNASDGIVNEVLIDLKQPDDAASMDNIVNREVSPEDLISYAHKISGTTSAPFGYQPNAPLASLFKPPAPQDEMMRSSVLFTKPPPHVLKYYGLAEIDVTTPTMAANISSPFSIGGNVGDVTTPTSKEQEDQQQQQQQQQPQQQLSQSQQSQQQTESELQPIQSILQPPQQLNIDLDLNPDLDSSGDDDDEDDDDEESEEVEWD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
336 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
37.035 kDa
Sequence
MNSTPANSTPLPPLQPFTPGSSAATPAPIALTRSKPRRRLSSNVVGVSDRRRLLQMLQNVEEVSPGPDSASEAGESPSIRSQDEAHLEHLSSARICMDEDKELLIHQALPAFENTLLRFVQALSKYDFRQDLAETLMETESQFCEAVDELVEHQQAAQTIAALERVSEGLDDKIRDMIRKLAECRRELRNYQPNNENQSTLSSADLLTYATRIANFTTAPPYFRERPEHSKLPWPIEDEMRKGLLALMEVGKDKTELGELADPEKFAHTAANGVAPNGAAPVANGVAQNHNNGYAMERRLSTGYGSDNDGDTNMNGRSGLAGLDIFDDDDDDDDDD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
336 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
37.035 kDa
Sequence
MNSTPANSTPLPPLQPFTPGSSAATPAPIALTRSKPRRRLSSNVVGVSDRRRLLQMLQNVEEVSPGPDSASEAGESPSIRSQDEAHLEHLSSARICMDEDKELLIHQALPAFENTLLRFVQALSKYDFRQDLAETLMETESQFCEAVDELVEHQQAAQTIAALERVSEGLDDKIRDMIRKLAECRRELRNYQPNNENQSTLSSADLLTYATRIANFTTAPPYFRERPEHSKLPWPIEDEMRKGLLALMEVGKDKTELGELADPEKFAHTAANGVAPNGAAPVANGVAQNHNNGYAMERRLSTGYGSDNDGDTNMNGRSGLAGLDIFDDDDDDDDDD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
323 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
37.008 kDa
Sequence
MLPFKKADSPFKSNPVSRVGSSTRLNQLGNIKSNPTTPNAALYVTSSLNPSKNLPTNAANVKSRLQTQKDLDAFKQLPMVQKVNEYERLLNELSEAVSQFKNDELQEKIGQIITCNDVLKQQIEDLNKHRNYSYEVDKLSDRNKILEENSKFILKELVSYRNELKKLPKLPKSDKMVNRNVDVDDILKYAFKLAKFTKAPATVANMPFQIHPNNYVWPAEDSLRRGMLAQASLQAEEIIRHELGETDKENSNEVKTESKVDHDDDDDDEMEDVRISNENTNDEQRSKPPAASEHDTSKRKEEQNQQPVDLNLDLFDPDDEYSD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
322 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
35.51 kDa
Sequence
MIPHKKNDSSFLSVPVSRVGSTQRLNQLASHGVATGSPNAYSSIPSTPSAYVSSSLNPTKGISAGPESSNQIITKEDRDAFGKLSIVEKVNEFEQNLTNLSFKVSSFKEDELASLIGKLIELNDIICSEIGELKKHRDLGILIKGLKDDQAHLDNTSKIILKELITYRNELKKLPRLPSNKNKASVFPSPNDSKVDVNEVLKYASKLSKFTKAPPTVSNLPFQIHPNNYVWPAEDALRRGMLAMSSIKVDDIINAELGEDTLEVKEEAIKKVEDNKVESITNSPPAERRGSFGERTGESRKQESQGALDLDLFDPDEEDFSD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
322 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
35.51 kDa
Sequence
MIPHKKNDSSFLSVPVSRVGSTQRLNQLASHGVATGSPNAYSSIPSTPSAYVSSSLNPTKGISAGPESSNQIITKEDRDAFGKLSIVEKVNEFEQNLTNLSFKVSSFKEDELASLIGKLIELNDIICSEIGELKKHRDLGILIKGLKDDQAHLDNTSKIILKELITYRNELKKLPRLPSNKNKASVFPSPNDSKVDVNEVLKYASKLSKFTKAPPTVSNLPFQIHPNNYVWPAEDALRRGMLAMSSIKVDDIINAELGEDTLEVKEEAIKKVEDNKVESITNSPPAERRGSFGERTGESRKQESQGALDLDLFDPDEEDFSD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
302 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
33.545 kDa
Sequence
MFPHKKNDPLKSLPISRVGSSQRLNQHISSIPSTPNYVASSLNPVRNLPVSSGSIKSKITTKAALDKFEQLPIVKQVGAFEDTLNAISDNISQFKEGQLHANVEKIIAINDDLKSKIEELDRHRRLGENIKELEAESSNLDNTSKYILKELISYRNELRALPRLPASASKGSGDTVEIEDILKYAMKLAKFTKAPATSASMPFQIHPNNYVWPAEDALRRGMLAASSLNPDEIIANELGTTEEEKIQEKKDEQVKKADKQQDTGIRRGSFGDYGSSSSGKKKEEQSAQLDLDLFDSEDEFSD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
302 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
33.545 kDa
Sequence
MFPHKKNDPLKSLPISRVGSSQRLNQHISSIPSTPNYVASSLNPVRNLPVSSGSIKSKITTKAALDKFEQLPIVKQVGAFEDTLNAISDNISQFKEGQLHANVEKIIAINDDLKSKIEELDRHRRLGENIKELEAESSNLDNTSKYILKELISYRNELRALPRLPASASKGSGDTVEIEDILKYAMKLAKFTKAPATSASMPFQIHPNNYVWPAEDALRRGMLAASSLNPDEIIANELGTTEEEKIQEKKDEQVKKADKQQDTGIRRGSFGDYGSSSSGKKKEEQSAQLDLDLFDSEDEFSD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
294 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
32.151 kDa
Sequence
MSANQLSKAATPKATPLGAAQGASSTSLHSFTSFQPQDASHVEQNKLHSVAIYEDLCQYEESLQRLVTSVDKFQPDLEAAQELIEIDSKLYSNLAQLPKYDLIDSQLKKLEEESKDIDERTAKILGILGECYNDLNSLPMVEQVEFEMATMKKQKDKVNSSVLLEYAMKLSKFTRVPPTFNKDAIGPNNFIWPAEDAIRRGMLAMASLKSKELTSLPGQSDQEAEQASAGKEADTAGPGVSTLEPANGGHNRRGSFEFTGIRKPPPASDADSSVVDDGDASMDLDLNLFNPDEF

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
285 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
33.048 kDa
Sequence
MSTPGPVPSSTSVATLPFSAQDKTQEQVSEELQSVGIYQDLERYEETIQQLSKSVDTFKPDLSLIDKVIECDKKLYETLEEFDEYYKIEEELSRLDKEQKNIDNKTREILETLNTCYNSLNELPMLEQVEFEQKVMLKQREKIHSKVVLDYAMKLAKFTRFPPTFDKSMIGPNNFIWPAEDSLRKGMLAMASLKKKELLLDALDEDNVNNDNNTSKIDEMRNTNEDSVDDRFNNKEQVQDATEDTERRGSFEFTANGKEDSETKSEENPDLELDLDLDLFNPDEF

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
285 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
33.048 kDa
Sequence
MSTPGPVPSSTSVATLPFSAQDKTQEQVSEELQSVGIYQDLERYEETIQQLSKSVDTFKPDLSLIDKVIECDKKLYETLEEFDEYYKIEEELSRLDKEQKNIDNKTREILETLNTCYNSLNELPMLEQVEFEQKVMLKQREKIHSKVVLDYAMKLAKFTRFPPTFDKSMIGPNNFIWPAEDSLRKGMLAMASLKKKELLLDALDEDNVNNDNNTSKIDEMRNTNEDSVDDRFNNKEQVQDATEDTERRGSFEFTANGKEDSETKSEENPDLELDLDLDLFNPDEF

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
284 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
32.205 kDa
Sequence
MSVQDTKAVEFSMGHIRSSSVSLVAEATSNTNSEDKLSKVQLYEDLCRYEDTLSKLVESVDRFKPNLDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNECHDELKALPMLEQVEFEKNTILQQRSKINSTELLDYATKLSKFTKIPPTFDKGAVGPNNFIWPAEDALRRGMLAMASLHSKELTRIPGEEVEETEVPTVPPSQSEEQKGQMAKKEGTPKTDSFIFDGTAKEVGDEADNTKDKEKEENNDDALDLDLDLFDPDDF

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
284 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
32.205 kDa
Sequence
MSVQDTKAVEFSMGHIRSSSVSLVAEATSNTNSEDKLSKVQLYEDLCRYEDTLSKLVESVDRFKPNLDIAKDLIRTDEALFENVKLLAEYDNIYRNLQKIDKDSEELDSKTRKILEILNECHDELKALPMLEQVEFEKNTILQQRSKINSTELLDYATKLSKFTKIPPTFDKGAVGPNNFIWPAEDALRRGMLAMASLHSKELTRIPGEEVEETEVPTVPPSQSEEQKGQMAKKEGTPKTDSFIFDGTAKEVGDEADNTKDKEKEENNDDALDLDLDLFDPDDF

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
278 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
30.84 kDa
Sequence
MEDVLSTHFDRIEKALSTLVDSIAAYNPSPQAAIDLVAADDQLSHGLDQLSRHQANHARILTLRAQVEALEEQKKSSVTALATLRHELHATPATSFPADTRPVRFDELLQYAKNISQYTVPPTYRERAPEAASDKDRDKDDAASSGVNTPAHAPAQPDSDAPKDRDNADNKPAEVTAEEEEWLEKLQKSQIAWYPWPSEEKIRIGNLSKLMYWQARGKDVDDFDIPAHEEAQRKGLAGVVEAPPEPEPVAEPVQAQAPRPARPAQPQATFDMFDDLDD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
278 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
30.84 kDa
Sequence
MEDVLSTHFDRIEKALSTLVDSIAAYNPSPQAAIDLVAADDQLSHGLDQLSRHQANHARILTLRAQVEALEEQKKSSVTALATLRHELHATPATSFPADTRPVRFDELLQYAKNISQYTVPPTYRERAPEAASDKDRDKDDAASSGVNTPAHAPAQPDSDAPKDRDNADNKPAEVTAEEEEWLEKLQKSQIAWYPWPSEEKIRIGNLSKLMYWQARGKDVDDFDIPAHEEAQRKGLAGVVEAPPEPEPVAEPVQAQAPRPARPAQPQATFDMFDDLDD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Homo sapiens
Length
270 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
29.745 kDa
Sequence
MAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD

Gene
Med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Mus musculus
Length
270 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
29.781 kDa
Sequence
MAASSSGEKEKERMGGVSGMAGLGSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSSDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD

Gene
Med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Rattus norvegicus
Length
270 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
29.826 kDa
Sequence
MAASSSGEKEKERMGGVSGMTGLGSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSTDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Homo sapiens
Length
270 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
29.745 kDa
Sequence
MAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD

Gene
Med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Mus musculus
Length
270 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
29.781 kDa
Sequence
MAASSSGEKEKERMGGVSGMAGLGSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSSDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD

Gene
Med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Rattus norvegicus
Length
270 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
29.826 kDa
Sequence
MAASSSGEKEKERMGGVSGMTGLGSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKVHHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTSGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSTDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Bos taurus
Length
270 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
29.707 kDa
Sequence
MAAASSGEKEKERPGGGLGAAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQSGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMAMNMLPPNHSHDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
264 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
29.618 kDa
Sequence
MSLVAESNSGTISEQELDKVQLYSDLCLYEEALTKLVDSVDNFKPQLEIGKQLIEADKKLYSTLDLLPQYDSVFTRLRTLDDEISKVDQQTKNILSILNECHDDLNALPLLEEVEFEKKMILKQREKIKSNVLLEYATKLAKFTKIPPTFDKGTIGPNNFIWPAEDALRKGMLAMASLHGKELTKLPGQEDGEEDGSTANEDKNIVKDAEGAEGEIRQDDKKEDDSFVFGANANDAEGDEDKNAGEDEDEAMDSDLDLFNPDEF

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Aedes aegypti
Length
263 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.681 kDa
Sequence
MSSYHLSTKERLLAIVDDIEIISKELIENTIAPKHQKMSSADHGQLVELLVSKDKELKATLQLAAEQAGIEKKMDGLREQVKEQDEEINQLQKQLKEAEHILATSIFQGRQKLSSINKAVKRPVSSEELIKFAHRISASNAICAPLTWQQGDLRRPYPTDIEMRLGFLGKSDLNINGHNAPNQNNLNEMQRNAAGAGAGSGVADIPASAQNQFAWHPSGELHMTMGAGAGSVSLDTRSHKDASQDDVEVMSTDSSSSSSSDSQ

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Anopheles gambiae
Length
263 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.751 kDa
Sequence
MSSYHLSTRERLLAIINDIEIVAKELIENTIAPKAQKMSSTDHAQLVELLVLKDKELKATLQLAAEQAGIEKNMDALREQVRKQDEEINQLQRQLKEAEQILATSIFQARQKLASIAKANKRPVSSEELIKFAHRISASHAICAPLTWQQGDLRRPYPTDIEMRLGFLGKSDLNINGHNLQHPNSLNEMHRNASTVGAGGAGGDIPASAPNQFAWHPSGELHMSMGAGAGSVSLDTRAHKDASQDDVEVMSTESSSSSSSDSQ

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Drosophila melanogaster
Length
258 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.313 kDa
Sequence
MSFHLSTKERLLLLIDDIEMIAKELIEQAHQKISSTELVDLLDLLVAKDEEFRKMLELAEEQAKVEEAMDQLRAKVEVHDREIQKLQKSLKDAELILSTAIFQARQKLASINQANKRPVSSEELIKYAHRISSANAVSAPLTWCIGDLRRPYPTDIEMRNGLLGKSEQNINGGTVTHQNSGMPSEQQRTLSGSAGSGSGSGAGGEVPNAFQNQFNWNLGELHMTMGASGNTVALETRAQDDVEVMSTDSSSSSSSDSQ

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Drosophila melanogaster
Length
258 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.313 kDa
Sequence
MSFHLSTKERLLLLIDDIEMIAKELIEQAHQKISSTELVDLLDLLVAKDEEFRKMLELAEEQAKVEEAMDQLRAKVEVHDREIQKLQKSLKDAELILSTAIFQARQKLASINQANKRPVSSEELIKYAHRISSANAVSAPLTWCIGDLRRPYPTDIEMRNGLLGKSEQNINGGTVTHQNSGMPSEQQRTLSGSAGSGSGSGAGGEVPNAFQNQFNWNLGELHMTMGASGNTVALETRAQDDVEVMSTDSSSSSSSDSQ

Gene
med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Danio rerio
Length
254 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.053 kDa
Sequence
MAAAAADKSTKERLLSTLDDLEVLSRELIEMLALSRSQKLPPPGEDTLILELLIQRDKEFQELMQTALEQGRVHQEMQSLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIDKARKGSISSKEIIKYAHRISASNAVCAPLNWVPGDPRRPYPTDLEMRSGMLGNMSNMSTNGVNGHLPGDALAAGRLPDVLTPQYPWQSTDVSMGILPPHHGNDFGLEPPGHNKENEDDVEAMSTDSSSSSSDSD

Gene
med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Danio rerio
Length
254 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.053 kDa
Sequence
MAAAAADKSTKERLLSTLDDLEVLSRELIEMLALSRSQKLPPPGEDTLILELLIQRDKEFQELMQTALEQGRVHQEMQSLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIDKARKGSISSKEIIKYAHRISASNAVCAPLNWVPGDPRRPYPTDLEMRSGMLGNMSNMSTNGVNGHLPGDALAAGRLPDVLTPQYPWQSTDVSMGILPPHHGNDFGLEPPGHNKENEDDVEAMSTDSSSSSSDSD

Gene
med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Xenopus laevis
Length
252 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.056 kDa
Sequence
MAVPKKSTKERLESLLDDLEVLSREVIETLALSRSQKLSQPGEENQILELLIQKDGEFQELMKVAFSQGKTHQEMQVLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIDKARKGVISSEELIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMSNLPTNGVNGHLPGDALAAGRLPDVLAPQYPWQSSDMSMNMLPPNHSNEFLMESLGPNKENEEDVEVMSTDSSSSSSDSD

Gene
med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Xenopus tropicalis
Length
252 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.141 kDa
Sequence
MAVPEKSTKERLMSFLDDLEVLSRELIEMLALSRNQKLSQPGEENQILELLIQKDGEFQELMKVALSQGKIHQEMQVLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIDKARKGAISSEELIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMSNLPTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSNEFLMESLGPNKENEEDVEVMSTDSSSSSSDSD

Gene
med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Xenopus laevis
Length
252 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.056 kDa
Sequence
MAVPKKSTKERLESLLDDLEVLSREVIETLALSRSQKLSQPGEENQILELLIQKDGEFQELMKVAFSQGKTHQEMQVLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIDKARKGVISSEELIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMSNLPTNGVNGHLPGDALAAGRLPDVLAPQYPWQSSDMSMNMLPPNHSNEFLMESLGPNKENEEDVEVMSTDSSSSSSDSD

Gene
med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Xenopus tropicalis
Length
252 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
28.141 kDa
Sequence
MAVPEKSTKERLMSFLDDLEVLSRELIEMLALSRNQKLSQPGEENQILELLIQKDGEFQELMKVALSQGKIHQEMQVLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIDKARKGAISSEELIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMSNLPTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSNEFLMESLGPNKENEEDVEVMSTDSSSSSSDSD

Gene
med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
239 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
27.34 kDa
Sequence
MEYQRAIDSIEECLNKQLRLSSEKVDQYVLIENWTSLVGHLKTLHSLISNYTNGRELQNEISSLLKQDKELDLQIQDCMREMTSIYDTHLPKTVSGRKRQKVNAETLLDYGRKLSKFSSAPPGYNPETGQDAKAPVHYPWPSEDQMRKTLLFQFSTSMVPNLSATASQLFSEQPPKTNEPTETETEIDANKAVEEKTKMNYPASPTFTTQEENKEVESPANKDVFAGFDLFDPEMEEDF

Gene
med4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
239 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
27.34 kDa
Sequence
MEYQRAIDSIEECLNKQLRLSSEKVDQYVLIENWTSLVGHLKTLHSLISNYTNGRELQNEISSLLKQDKELDLQIQDCMREMTSIYDTHLPKTVSGRKRQKVNAETLLDYGRKLSKFSSAPPGYNPETGQDAKAPVHYPWPSEDQMRKTLLFQFSTSMVPNLSATASQLFSEQPPKTNEPTETETEIDANKAVEEKTKMNYPASPTFTTQEENKEVESPANKDVFAGFDLFDPEMEEDF

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
234 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
26.249 kDa
Sequence
MAHTTPRSHPPPHSLLQNLTTQSLLLSHLFTLIASPPNPNTSTQTQLNQVYSALQLSTLDLSGLVKEVGHHQEAYRRLVEKKNEVAGLEMRVRGLVKRLEEGRKELEGMIDQGERSLEDIEKSEREPVPAKTLMAHAQSLSKHSSAPVSSLLAPVDKAQYAPWPTEMSMRMGLLFQLEGSMSGMGERGVVGEEQKAPQKVEERREHVEHEESDRRYDPNAVFQLDLNSDESDED

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
234 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
26.249 kDa
Sequence
MAHTTPRSHPPPHSLLQNLTTQSLLLSHLFTLIASPPNPNTSTQTQLNQVYSALQLSTLDLSGLVKEVGHHQEAYRRLVEKKNEVAGLEMRVRGLVKRLEEGRKELEGMIDQGERSLEDIEKSEREPVPAKTLMAHAQSLSKHSSAPVSSLLAPVDKAQYAPWPTEMSMRMGLLFQLEGSMSGMGERGVVGEEQKAPQKVEERREHVEHEESDRRYDPNAVFQLDLNSDESDED

Gene
MED4
Protein
Mediator of RNA polymerase II transcription subunit 4
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
234 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 4 family.
Mass
26.19 kDa
Sequence
MAHTTPRSHPPPHSLLQNLTTQSLLLSHLFTLIASPPNPNTSTQTQLNQVYSALQLSTLDLSGLVKEVGHHQEAYRRLVEKKNEVAGLEMRVRGLVKRLEEGRKELEGMIDQGERSLEDIQKSEREPVPAKTLMAHAQSLSKHSSAPVSSLLAPVDKAQYAPWPTEMSMRMGLLFQLEGSMSGMGERGVVGEEQKAPQKVEERREHVEHEESGRRYDPNAVFQLDLNSDESDED