MED25

Mediator of RNA polymerase II transcription subunit 25

863 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.

Belongs to the Mediator complex subunit 25 family.

96.642 kDa

MEVDQIPLADVVFVIEGSAINGAYINELKTNYILPTLEHFTTGSIDEREYLIAERFATLYGIVVYRTAANLLEPVCSTYGPFLQPQKVMETIERLPLVGGGMESCAHMAEGFAAAHGCFDDISERRQLLDQTSVQRHCILICNSPPYQMPTTESWKYPGKSCEQLAALFNERKINLSIIAPRKMPVLFKLFMKADGDQPITSKNYAKNIRHLVLLKGYSLKERAPSPNSMAAQMAAPNAAQATVQQQQQQQQNQAGQQQQGQGMPMDTTPAQQQQQQQQQQQQQQQQGNPQQQVMNMNTMQQQQPGPNPPAGLLNPQQQQQLLQQQQQNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQARPPFMQGAGNVGGVGQGGGMQQNPNSALISRINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQRMQMLSQQQMLNHQQLQQQQQLAQQQQQQQQGQQQQQVNPNAGNNMMPASNAGNMSNPQQQQQQVGQQSNPQQQGNPQQQQQGNSQQEQASLREKIWTGVLEWSEKPKSDQQKIPHTLQCTVCTNIKDGEPEIKAENWPPKLLMQLMPKHLVGNIGGQFLKDSKMVVFRPTPGEALDSLAKMMTSGYAGCVHFSSIPNSPACDLKVLILLYTPDRNAFLGFIPNNQAMFVERLRKVIQQKQHGNMQQQQQQQQMMQQQGKSPMELQQQQQQQQQQQQMQQDNSQQQHYNQFQLNMQMGGGGPGGGPGPGPGGMPMQQNQMQMNMMQQQRMPLGVGVGVGVGPGGVPNPNLQQQLQQVAPNVAAMQQQQAQQQQQRMVRPMMSNNNPGLRQLLQHQTTPGNQFRPQMGGQNPNQMGAGGPMVGNRNFDDGNYEFM

MED25

Mediator of RNA polymerase II transcription subunit 25

836 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Positive regulator of shade avoidance and of jasmonate signaling. Acts in repression of PhyB-mediated light signaling and regulates the expression of FLOWERING LOCUS T (FT) and of CONSTANS (CO).

Belongs to the Mediator complex subunit 25 family.

89.566 kDa

MSSEVKQLIVVAEGTAALGPYWQTIVSDYLEKIIRSFCGSELNGERNPVSTVELSLVIFNSHGSYCACLVQRSGWTRDVDIFLHWLSSIQFGGGGFNEVATAEGLAEALMMFSPPSGQAQPSNDLKRHCILITASNPHILPTPVYRPRLQNVERNENGDAQAESRLSDAETVASYFAKCSVSLSVVCPKQLPTIRALYNAGKPNQQSADLSIDTAKNTFYLVLISENFVEACAALSHSATNLPQTQSPVKVDRATVAPSIPVTGQPPAPVSSANGPIQNRQPVSVGPVPTATVKVEPSTVTSMAPVPSFPHIPAVARPATQAIPSIQTSSASPVSQDMVSNAENAPDIKPVVVSGMTPPLRTGPPGGANVNLLNNLSQVRQVMSSAALAGAASSVGQSAVAMHMSNMISTGMATSLPPSQTVFSTGQQGITSMAGSGALMGSAQTGQSPGPNNAFSPQTTSNVASNLGVSQPMQGMNQGSHSGAMMQGGISMNQNMMSGLGQGNVSSGTGGMMPTPGVGQQAQSGIQQLGGSNSSAPNMQLSQPSSGAMQTSQSKYVKVWEGNLSGQRQGQPVLITRLEGYRSASASDSLAANWPPTMQIVRLISQDHMNNKQYVGKADFLVFRAMSQHGFLGQLQDKKLCAVIQLPSQTLLLSVSDKACRLIGMLFPGDMVVFKPQIPNQQQQQQQQLHQQQQQQQQIQQQQQQQQHLQQQQMPQLQQQQQQHQQQQQQQHQLSQLQHHQQQQQQQQQQQQQHQLTQLQHHHQQQQQASPLNQMQQQTSPLNQMQQQTSPLNQMQQQQQPQQMVMGGQAFAQAPGRSQQGGGGGQPNMPGAGFMG

MED25

Mediator of RNA polymerase II transcription subunit 25

805 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Plays a positive role in wound-induced activation of jasmonate-responsive genes whose promoters are targeted by MYC2 (PubMed:30610166).

Belongs to the Mediator complex subunit 25 family.

86.438 kDa

MVDKLIVAVEGTAVLGPYWKIIVSDYLDKIIRCFFGVDSTSQKSSAADVEVSMVMFNTHGPYSACLVQRSGWTKDMDTFLQWLSAIPFSGGGFNDAAVAEGLAEALVMFSVPNGNQTQQKMEGKKHCILISGSNPYPLPTPVYRPQMQKLEQNENIEAQTDSRLADAETVAKTFPQCSISLSVICPKKLPKLRAIYDAGKHNPRAADPPIDTAKNPNFLVLISENFIEARAAFSRSGLTNLASNHSPVKMDVSSVLPVSGTQSISNSAANVSVISRPPISAGNIPPATVKIEPNTVTPMTGPGFSHIPSVRPALQPVPSLQASSPLSVSQEMVSHTENVQEMKPIVSGMTQSLRPVAAAAANVKILNGVAQAHQVLGGGTSIGLQSMGGTPMLSSMISSGMASSVPASQAVLSSGQSGVTTMTGAVPLAGSAQNTQNSAPSSFTSTAPSMSGQTVPAMSQGNIPGTQMMPSGTGMNQNMLTGLGATGLPSGTGTMMPTPGMSQQGQPGMQPVGVNSTSANMPLSQQQTSGALPSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASESLAANWPPTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLSQLQEKKLCAVIQLPSQTLLLSVSDKACRLIGMLFPGDMVVFKPQIPSQQQQQQQQQQLQAQHPQLQQQQQQQQQHLTQLQQQPLQQLQQQQQQQPLMQLQQQQQIPLQQSQVPQMQQQQIHQMQQQQQIPQMQQQQQIPQMQQQQQQQPMVGTGMNQTYMQGPARSQLMSQSQGSSQGLPITPGGGFMN

med25

Mediator of RNA polymerase II transcription subunit 25

805 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 25 family.

87.144 kDa

MDAATPGNGGIISDVVFVIEGTANLGPYFESLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVQWLDSIRFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHKVCILICNSPPYLLPAVESTTYSGYTTENLVQKIGERGIHFSVISPRKLPALRTLFEKAMPVGLIEPQPKDYSQDPRHMILVRGMVLPVGGATSVPGVIPPKQPISQPPLPVVPPQIANAPSHQLPPVQPPYMQVPQQNTLTTAHAAAQSAVEAAKNQKNNLPNRFPLPNLNQMPPTSAVGTPFNQPPPPAMPQNTSVPKMVTSTASLMTPASQPSLVTTVTTGPGPAPVQLQQQGAQQQPVPPSMPITGAAGGVQAPQPSQPQIGTAQLPCTQTPVNGNKLLAWSGVLEWQEKPRSVSVDNNAKLTRSLPCQVYVNPGENLKTDQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGSGFQAGCVHFPHTTPCEVRVLMLLYSSKKKIFMGLIPNDQSGFVNGIRQVITNHKQVQMQKIDQQRNMGAGQAVGTGNVPANTQAFLQKQPGALPVAQAVPQQMQGQQVAPGMPSISQVTMMDEQQRTQNLLHIRVQQPQQAASQAPPQATQTTVQAPGQPQNPQPGAMLRPQNPGANPQLRNLLLSQQPPQTSVPQTQQPLHHMQQAAQGMLPHQAMGQQMQHQAPGQQQLQLPGQTLMHQAPAQQWGNQMQQRAPIPGTLMMSAGPRGPVPQQGLQQVQAQSVMEDDILMDLI

med25

Mediator of RNA polymerase II transcription subunit 25

801 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 25 family.

86.512 kDa

MDAATPGNGIISDVVFVIEGTANLGPYFESLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVQWLDSIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHKVCILICNSPPYLLPAVESTTYSGYTTENLVQKIGERGIHFSIISPRKLPALRTLFEKAMPVGLIEPQPKDYSQDPRHMILVRGMVLPVGGATSVPGVMPPKQHISQPPLPVVPPQIASAPSHQLPPVQPPYMQVPQQSTLTPAHAAAHSAVEAAKNQKNSPSNRFLLPNLNPMPNAPAVGTPFNQPPAPTLPPNASVPKMVPSPSSLMTPASQSSLITTVTTGPGPAPVQLQQQGAPQQPVPPSMPITGAVGGVQAPQPSQPQIGTVQLPCTQTPVNGNKLLAWSGVLEWQEKPRSVSVDNNAKLTRSLPCQVYINPGENLKTDQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGSGFAGCVHFPHTTPCEVRVLMLLYSSKKKIFMGLIPNDQSGFVNGIRQVITNHKQVQMQKIDQQRNMGAVQGVGAGSVPANSQGFLQKQPGTLPVGQAVSQQMQGQQVAPGMPSISQVAMMDEQQRSQNLLHIRVQQPQQLASQAPPQATQSSVQAPGQPQNPQPGAMLRPQNPGANPQLRNLLLSQQPPQSSVPQTQQPLHHMQQAAQSMLPHQAMGQQMQHQAPGQLQLPGQSLMHQTPAQQWGNQMQQRAPIPGTLMMSAGPRGPVPQSGLQQVQAQSVMEDDILMDLI

MED25

Mediator of RNA polymerase II transcription subunit 25

747 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.

Belongs to the Mediator complex subunit 25 family.

78.171 kDa

MVPGSEGPARAGSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQSKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPQLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGAASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI

MED25

Mediator of RNA polymerase II transcription subunit 25

746 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription (By similarity).

Belongs to the Mediator complex subunit 25 family.

78.11 kDa

MVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTETLVQKIGERGIYFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPAGATLSTAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQATPGVGPPYSQTQATQLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLDSLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAAAGQPQPQGAAPAPPGAPQGPPGAAPGPPPPGPLLRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRASLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI

Med25

Mediator of RNA polymerase II transcription subunit 25

745 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription (By similarity).

Belongs to the Mediator complex subunit 25 family.

78.113 kDa

MVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQQPADVSQDPRHMVLVRGLVLPVGGSSTSGSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLAPVPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQLGGPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPVLGPILEEQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI

med25

Mediator of RNA polymerase II transcription subunit 25

701 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 25 family.

75.463 kDa

MDPTSKSGLNQVSDVVFVIEGTANLGPYFESLRNNYILPTIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADSLVQIIRDRGIHFSVIAPRKLPALRSLFERASSVAGLPESSHPDYSQDPFHMVLVRGIALPVAPGGGSVPVSLKPVLPPQSLPVNQNPLVPVASTAPQMNTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVANKVVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVSQGENLNTDQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDMESLKGLFRIMTSGFAGCVHFPHSAPCEVRVLMLLYSSRKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQQRSMQPGQVQPNQNFLNRPPGPIPVTHGNVPQQLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLLLSQQPQGGMQGMQGMHPIQQMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSVMEDEILMDLI