MED2

Mediator of RNA polymerase II transcription subunit 2

431 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.

Belongs to the mediator complex subunit 2 family.

47.718 kDa

MVVQNSPVSSVHTANFSERGSNTRTMTYKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQSQQKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGKEKEKEREEAEKKRAEQENMRKVREQEELKKRQELEEASQQQQLQQNSKEKNGLGLNFSTTAPANTTDANGSKENYQELGSLQSSSQTQLENANAANNGAAFSPLTTTRIQSQQAQPSDVMFNDLNSMDISMFSGLDSTGFDSTAFNATVDETKGFDDNDSGNNYNDINISSIENNINNNINSTKNGKDNNNESNKNNNGDEKNKNNNEDNENNNNSSEKNNNNNNNNNNNNDDNGNNNNNNSGNDNNNTTNNDSNNKNNSITTGNDNENIVNNDLPTTVVSNPGDNPPPADNGEEYLTLNDFNDLNIDWSTTGDNGELDLSGFNI

MED2

Mediator of RNA polymerase II transcription subunit 2

431 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.

Belongs to the mediator complex subunit 2 family.

47.718 kDa

MVVQNSPVSSVHTANFSERGSNTRTMTYKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQSQQKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGKEKEKEREEAEKKRAEQENMRKVREQEELKKRQELEEASQQQQLQQNSKEKNGLGLNFSTTAPANTTDANGSKENYQELGSLQSSSQTQLENANAANNGAAFSPLTTTRIQSQQAQPSDVMFNDLNSMDISMFSGLDSTGFDSTAFNATVDETKGFDDNDSGNNYNDINISSIENNINNNINSTKNGKDNNNESNKNNNGDEKNKNNNEDNENNNNSSEKNNNNNNNNNNNNDDNGNNNNNNSGNDNNNTTNNDSNNKNNSITTGNDNENIVNNDLPTTVVSNPGDNPPPADNGEEYLTLNDFNDLNIDWSTTGDNGELDLSGFNI

MED2

Mediator of RNA polymerase II transcription subunit 2

368 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 2 family.

41.05 kDa

MSYKNRLTACFDDILKVSAEMMMQQQLKNVQLDPYMVNGFSAQQQNTLKEKIHMFHGILDDLENMLSKSTYYVDTLANLGKESKRQKELELEKQREQEEEEKKQKLLELERKKKEQEEEEEKKKKQKEEEEKRKKELEEQERKKKEQEEEEKRRRQQEQDGDKQQSMFDGLDFTNADLDTSQPGTSGQNDIKSPTMGAGPQTAGTDKPNTADGPDKTNPPIAAFGLGDSQSGGLYNDLNTMDLSMFSELDGGGFDASGFDTANTSNANATTNSVPNNNNPATNDSNMNNDPTAAINAFDGTAAGNNETLGQGEKLEFDQSNPSAMLGNDINMGDNGEDYLTLNDFNDLNIDWSAAGEGGDLDLNGFNI

MED2

Mediator of RNA polymerase II transcription subunit 2

368 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 2 family.

41.05 kDa

MSYKNRLTACFDDILKVSAEMMMQQQLKNVQLDPYMVNGFSAQQQNTLKEKIHMFHGILDDLENMLSKSTYYVDTLANLGKESKRQKELELEKQREQEEEEKKQKLLELERKKKEQEEEEEKKKKQKEEEEKRKKELEEQERKKKEQEEEEKRRRQQEQDGDKQQSMFDGLDFTNADLDTSQPGTSGQNDIKSPTMGAGPQTAGTDKPNTADGPDKTNPPIAAFGLGDSQSGGLYNDLNTMDLSMFSELDGGGFDASGFDTANTSNANATTNSVPNNNNPATNDSNMNNDPTAAINAFDGTAAGNNETLGQGEKLEFDQSNPSAMLGNDINMGDNGEDYLTLNDFNDLNIDWSAAGEGGDLDLNGFNI

MED2

Mediator of RNA polymerase II transcription subunit 2

343 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 2 family.

37.087 kDa

MIKELQGGNMATKFKTDEEMRGDRLTQCLDDIMRASTEMMVQQQLKTIQLNSDVAAGFRKALSKSLGDRVRAFHSILDGVETTLTTASQYLDAVEEAAVKMKQWKQQQEEEQRRKHQAELEKNKRQQEHDAATKAAAAQQLMAQQSPVDLTAPTPTGLASNLDKSNRVGGVKPFSAEFGHLDEMDLSMFGGIDGHGDFSLEDFNMGGNSVPLNGGRPRNMVMADAGGFPARGGMGRGGATAINNGAQEIKTSTNEASTNNRNNDGTGGASNPRISSNYNSAVADHESIGLRVDANGQNTKQSGQQSGAGLNPDDYLTLNDFNDLGIDWNTGENNELDLNDFNI

MED2

Mediator of RNA polymerase II transcription subunit 2

343 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 2 family.

37.087 kDa

MIKELQGGNMATKFKTDEEMRGDRLTQCLDDIMRASTEMMVQQQLKTIQLNSDVAAGFRKALSKSLGDRVRAFHSILDGVETTLTTASQYLDAVEEAAVKMKQWKQQQEEEQRRKHQAELEKNKRQQEHDAATKAAAAQQLMAQQSPVDLTAPTPTGLASNLDKSNRVGGVKPFSAEFGHLDEMDLSMFGGIDGHGDFSLEDFNMGGNSVPLNGGRPRNMVMADAGGFPARGGMGRGGATAINNGAQEIKTSTNEASTNNRNNDGTGGASNPRISSNYNSAVADHESIGLRVDANGQNTKQSGQQSGAGLNPDDYLTLNDFNDLGIDWNTGENNELDLNDFNI

MED2

Mediator of RNA polymerase II transcription subunit 2

280 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 2 family.

31.89 kDa

MVPKTGVSDRQENKLTQYFDDILRLSADLLTQQQLKTIKLDPKVTTGFSKAQQKGLGDRITQFYSLLDTLDVSLQTTADYVGAVKDSALQLKKQREEEQIKKQEQEKLERQLLEQQKLEQQQLEQKQLKQKQQQQQQQQQQQQQQQPQEQQHEQQQRYSAKNTPIDMLTNFDTDLPSAGITQAQSFNSEFGDLNGMDLSMFDSMDNQVGFGGLQNTSGGNEKKNDPQINFNDTNAPPSAVNVPENGNPSSYLTLNDFNDLGIDWNAANDNNELNLEDFNI

MED2

Mediator of RNA polymerase II transcription subunit 2

280 amino acids

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Belongs to the Mediator complex subunit 2 family.

31.89 kDa

MVPKTGVSDRQENKLTQYFDDILRLSADLLTQQQLKTIKLDPKVTTGFSKAQQKGLGDRITQFYSLLDTLDVSLQTTADYVGAVKDSALQLKKQREEEQIKKQEQEKLERQLLEQQKLEQQQLEQKQLKQKQQQQQQQQQQQQQQQPQEQQHEQQQRYSAKNTPIDMLTNFDTDLPSAGITQAQSFNSEFGDLNGMDLSMFDSMDNQVGFGGLQNTSGGNEKKNDPQINFNDTNAPPSAVNVPENGNPSSYLTLNDFNDLGIDWNAANDNNELNLEDFNI