About Products Protein Database Contact

MED15

Gene
med15
Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
1063 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Component of a med15-hrp1 subcomplex, linking the Mediator complex to the chromatin-remodeling activity of hrp1 at a distinct subset of hrp1-bound gene promoters.
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
118.453 kDa
Sequence
MNRNVDKGWQAQIRPNERQSIALQIAQTLRIISPSISEVQLMNMALSFERQAFDGASSKNEYLTTCGKKTAQLRDQIRDTLQATQMKQMPSVYNNAGNVGALPTAGPNRLANNPRVMPRLQNQNVPMQAGMQQFARNMKLTPQQRQFLLQQSQIQQQRQQQQQQSQQPQQTQQPQASSPTAPNTEANQQRSGSVPGRIVPALTQQQLNNLCNQITALLARNGNPPIPMQKLQSMPPARLISIYQNQIQKFRSLQHMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKQAPQNAFFPNPQGNVGAQSLQSMSPQDQPSTQQQQPQRTAAPPNNPNVNATNNNRINIEMLNIPVPKQLFDQIPNLPPNVKIWRDVLELGQSQRLPPEQLKLIGMLYRKHLQIILQHRQQQLNKIQNARMNSQNAPNTNKLGNPQPDNTGNPQAFSQQAFAQQQQQQQQQLHRTSNPTSASVTSQNGQQPINTKLSANAAKTNYQSYLTNKARNATQPTQPPVSQVDYSNNLPPNLDTSSTFRSSASPPSAFTKAGNEALSVPLSGARNTAASRPTNLAAGNSSASIVQQLLECGGTMGQQKMTSRIRELTERVMHSLMRPVPLDLPHDQKVMIASLIKSAYPMFSRTNQLICLFYCLTGNEEATIQLIQMRHIFKLQLEGLQQGVFTCAPQTLAKIKEKTSRYFAFVKAQLLRLHHEVNNNNMSIQNALAHISSLRTASINQQQQPQPQSQQQQQASQFPQAPSVSSNVRPINGSIPNAQPSVPGQAQPAAKANSVGNTSFPVDSKLAFQSLDVSQPDLQAKQKIASQVMKHGLKPEDLKLPPSKKKKIENLSTVQKPKDSVVNTPDVIMSSVDEIPSSVSPGTIAKEEGMAKAREEAIANPLKYAIDAFVAVDHEEEVSAIKSSQTPSSILKTPQSFFIPPSTPDLSFTDNKNSLSPSNILSLDGKFSFNDDSELWADLGNEINSEIGFLKEPDTMNLALDADKDKTKMQNKLTQINFDESCFLDPAIDDKDPWNEMLHEKKVLLKQLQVGNEDEDNIAFPTSTNIWQVVI

Gene
med15
Protein
Putative mediator of RNA polymerase II transcription subunit 15
Organism
Dictyostelium discoideum
Length
851 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
98.453 kDa
Sequence
MTDWKTTITPEERNGNSIKILDFLMQWYPNFNRAEALVRANTLEDRIFNTPGIISKNDYIERIAKKIYAIGESLEAKKAQAGMTNNPQTPNPMPTTPITPLIQQPITPVQQQVPPQKQPQPVYNQQQNQQQNQNQYTTTYPSPNTPQQSNTPPISNNNSNNNSNNNLNNNNNNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTVYAQPLTPQQQIQQQQHQQHQLYLQQQQQLQRLAQQNQQQQPTIMQQVQNQQPTQQQQQQQQQQQQQQQQQQLNQQQINQIKQQQQQQQQQQQQHQQPVQMPSGVTTNKQSPQPQNTPLTPQQQQQLLAAQQSHAQAQANQNQQLQNPKRISSTNNTHLMPCLPSTLYPTATQQDINNMYWERVSSIKKYIPEIEAIIPKIIENFSQSQNQQPQKVETYKKKFLDFVQMVKVTPETVVPPLNLDELTNAERYLMNMYLSSLSEEEQFKKILGTIDDRSNDNLIHFEKDLLNAFERTKRYFSDTFLNKTGGVTSKAPSILWFKNPALNNPFTSATKCQFSDPIVPKKKQHILLDSWTPEFKKIKKGNYEIFEKDQKIYNNLKKDLIDFTKNDNTLLPAKFIDKDTIIISETINGGDGGNNLYIHFNQCQFSTSWKGSKKNPAMFVCSSPNIQISSDGELFSIQPLCGLSWDRAEIIIKHYKQSLNRGDLISKELSQVISLNRYTIESHLDLENAKFFIQFSTKSTLLLKSKKQQQQQQDEKINNNNNNFYNLSILLEVPNNYPYSPISYSFPPEYQLTPYLKDLESKMNKEFENSNDLNQLNNNINNNNNNNNSFSDNTQLPTNQSIVESLKIFEKVLKDLV

Gene
med15
Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Danio rerio
Length
809 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway.
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
89.863 kDa
Sequence
MDVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTGHTKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIHKKAQGGPDPINALQNLPGGVPGVIGPRPPGAQMGGMGQMSMGPHAMQGVAGGQQGAGAAGPMQQMIQQQQQQQQQQQQQQSIQFQTFQPQQQQQATMQSQQPSAMFQQIRLQQLQQHHQNQQMQHQNQQQQQAQNQQQQNQLHQTRMQQQLQLQQLQQQQQQQLHQQQVHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMQQQQQLQVQAQGQPQVQGQGGAVQMPPHSQQQQVLVPQMVQGQHSQMSALSQQQQLKLQQAMQARMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQVQQVQQASQLTAVPGQMMPRPGMQIPPRLPRATPNSAIPQNPVAIGGQQMPQAQQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSQSPASSRTPQSYPLQVPSPGPLNTPGNPSSVMSPAGASQSEDQLYMDKLRQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPCTKKQYLCQPILDAVLANIRSPVFNHSLYRTFAPAMTAIHGPQITGPSIPSRKRKLEDDERQAIPNILQGEVARLNSKFLVNLDPSFCSNNGMVHLICKLDDKNLPSVPPLQLSIPADYPDQSPHWEDDGQQYEANPFLRTVHKNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSA

Gene
Med15
Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Mus musculus
Length
789 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway (By similarity).
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
86.607 kDa
Sequence
MDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTPGAAGIGMPPRGPGQSLGGMGGLGAMGQPLPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQSQQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPSMQQPQPPPSQALPQQLSQLHHPQHHQPPPQAQQSPIAQNQPPQIPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQPQAAVQAAQSAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSISLGGQPTTQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIVSPVVCSRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPMWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA

Gene
MED15
Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Homo sapiens
Length
788 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
86.753 kDa
Sequence
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA

Gene
MED15
Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Aedes aegypti
Length
779 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
82.337 kDa
Sequence
MAEDNSWKTPSFRQSVVNKINEAIQQSGMTSSKNGLEMENHVFQKARNKDEYLGYVARLILHVREMNTKNKNQQNPAGGSQDGGNPNQQGGMPDPINALQTLATQGTRPQMMGGQMGPGGPMGNQMGGGNASNLLNTLNRPQMPMTGGMANMQGRVGTMGGPNQMGGMMPGQMPQGMPGMPNQMGGAMGPGGMSGGKIVGQMNPMGQMNPMQMGVSGMPQGAGQQQPQQPQGQQGGPGGPNQMNPMGGMGMQVNPGGHMNQNAINQQMNQVGMSSGGNQMGNLGGNSPMNPGNMGIAPNQVIRQQMPPGMNPNQQQLGMAGGQMNQMNQGVGGPGGNLGPVQQQQQPGQVGMAGMGPGGPGNLQQQNNPQQQSQGGPNAAPGQMNQVGGPGGNMQAMGNQGNFVPIGANPMVRKQDMMSGGQVYPGGVVRSVTPNQFLRQSPSPSVPSPAGPGSIGPQSHPGQMIPSPALIPSPSPQVSSNIPAPRNIGQSPGQSLNTPGQAAAPSPLNPQEEHLYKEKYRSLQKYIEPLKRMIAKMEHDDVDKMGKMKRLLDILCNPTCRIPLETLYKCEAALTSQLGTIREPPLNNPLVEAVSANLQSPLGNHTLQRTFRPCLEALFGPDIKNLPTPAKQPRLAIDEPSTSGSTGSQEIPHILQGEIARLDQKFKVSLDPCAIGDTKTIKLICWLDDKHLPCVPPVAVTIPEEYPFTSPSCSLIEQEYNATPFLIQVQKSFLARICKLPEMFSLSHLLDTWEMSVRQACSPNPSLVAPSATSVLLGM

Gene
med15
Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Xenopus laevis
Length
777 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway.
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
86.686 kDa
Sequence
MDADSDWRSAPFRQKLVSQIDEAMRKAGVAHTKSSKDMESHVFLKAKTREEYLSLVARLIIHFRDILNKKSQAAATDPMNALQNLTGTAVVGGQGMGMGVRPQGAQMGAMSGMAQMAQQMNLPGQPQPGASGMAPHGITGVAAGNQATQLQLQQIAQHQQQQFQQQQQQAALQHQQQQFQVAQQQQFQVVAVAAAQQQQQQQQQQQQQQQQVQQQQQQLQAAAQQQHILKLQLQQQQNQQQQLQQQQQQQLQRIAHLQQMQQMQQQQQQQQQQQQQQQQQPPPQQVMQLQQMQQQQVAQSQQQQLLSTQPQAPSLVAQGQIPSQVMPVTLTPQQQQQLKILQQVRAQQQQQAQHQAQQQAQQQAHQQAQQQAQQQAQQQAAQQQAQQAAQQAQQQAQQAAQQQAAQAHLAAGQVTQNSIPVMSSPSPVQQVQTPQPMPPPPQPSPQPSQPMSQPNSNVSSGPAPSPSSFMPSPSPQPSQSPASARTPQNFSVPSPGPLNTPGNPNSVMSPASNNQSEEQQYLDKLKQLSKYIEPLRRMINKIDKNEERKKDLSKMKSLLDILTDPNKRCPLKTLQKCEIALEKLKNDMAVPTPPPPTVPSTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGQPIASQLVVPRKRKFEEDERQSIPNVLQGEVAKLHSKFLVNLDPSHCSNNGTVYLICKLDDKNLPSVPPLQLSVPADYPDQSPLWMDNPRDYEANPFLQSVYRYMTSKLLQLPDKHSLTALLNTWAQSIRQACLSAA

Gene
MED15
Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Anopheles gambiae
Length
762 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
78.119 kDa
Sequence
MAEDNSWKTSNFRQSVVNKINEAIQQTGMTSSKNGIEMENHVFHKARNKDEYLGFVARLILHVREMTAAAQQAQQDGGGNSSQQGGGGGGGGSGMPDPINALQNLASQGTRPQMMGQMGVGPGGPMGGQMGGAGQASNLLHSLRPQMQMGGMGGPMQGNRVGMGPGNQMGGMMGGPNQMQGPGAGMVGGMPGQMGVGMGPGGMSGGKIQMGVGPGGPNQMNPMVMGQIQAQLQNQNAMGGQQMGTVGGTMNAGNQMGQMVGANAGMNPQAMGMASNQVVRQQQLQQQGMGQVQMGLGPGQMGQLSAGVQGGVGHGGPAMQQQQQAGGMGPGAGPNQMNPGVAMGPGGVVGPAGGGGVMGPGPNQMLGAGGAGGPGAGQQGNFVGMGANAMVRKPPEMMPGGNVYPGSGGAVRSVTPNNFLRQSPSPSVPSPVGPGAHGPPSHPGQMIPSPALIPSPNPHMGGVAQRSTIGQSPGGSLNTPGQPGGAVPSPLNPQDEQLYREKYRALTKYIEPLKRMIAKMENDDIDKIAKMKRLLEILSNPSVRIPLETLHKCEAALTSQLGSIRETPTNNPLVEAVSSSLQAATGNHTLQRTFRPCLEALFGPDIKNLPPPAKQSRLALDDTGAAVGTGGGEIPHILQGEIARLDQKFKVSLDQCAISGTRTIKLICWLDDKNLPCVPPVAVTIPEDYPSTAPSCSLIEQEYNATPFLILVQKSLMARICKLPGLFTLSHLLDTWEMSVRQACSPNPTIVAPTGTSVLLGM

Gene
MED15
Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Drosophila melanogaster
Length
749 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
Similarity
Belongs to the Mediator complex subunit 15 family.
Mass
80.526 kDa
Sequence
MTEDWQSQKFRQNVISKIHDLLPPNAQDQTKNAGVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKSQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGAGGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMSNIRGQMPMGAGGAGAQQMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVGGAGGPNAAPGAGGPGPNQMQGGPMNVNAMQQMPPMQQIQQNQLGMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNPMGGMGVNMPPNLQQKPNMPMGQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQQQQQQLVVGNQTPTQQPPTPQMPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSPSASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIEPLKRMLAKISNDGTNVEKMTKMSKLLEILCNPTQRVPLETLLKCEKALEKMDLISYSGQQFGKSSNPLLEVINTTLQSPVANHTLYRTFRPTLELLFGTDITAPVPAKRPRVEEKSTSFEQEVPHVLQGEIARLDTKFKVKLDTTSQINNKAIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLAEQEYSATPFLQTVQQALIARISKLPKNYSLSHLLDTWEMAVRQACSPQSKPRAVCELSTLLGV