Protein
Mediator of RNA polymerase II transcription subunit 15
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Component of a med15-hrp1 subcomplex, linking the Mediator complex to the chromatin-remodeling activity of hrp1 at a distinct subset of hrp1-bound gene promoters.
Similarity
Belongs to the Mediator complex subunit 15 family.
Sequence
MNRNVDKGWQAQIRPNERQSIALQIAQTLRIISPSISEVQLMNMALSFERQAFDGASSKNEYLTTCGKKTAQLRDQIRDTLQATQMKQMPSVYNNAGNVGALPTAGPNRLANNPRVMPRLQNQNVPMQAGMQQFARNMKLTPQQRQFLLQQSQIQQQRQQQQQQSQQPQQTQQPQASSPTAPNTEANQQRSGSVPGRIVPALTQQQLNNLCNQITALLARNGNPPIPMQKLQSMPPARLISIYQNQIQKFRSLQHMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKQAPQNAFFPNPQGNVGAQSLQSMSPQDQPSTQQQQPQRTAAPPNNPNVNATNNNRINIEMLNIPVPKQLFDQIPNLPPNVKIWRDVLELGQSQRLPPEQLKLIGMLYRKHLQIILQHRQQQLNKIQNARMNSQNAPNTNKLGNPQPDNTGNPQAFSQQAFAQQQQQQQQQLHRTSNPTSASVTSQNGQQPINTKLSANAAKTNYQSYLTNKARNATQPTQPPVSQVDYSNNLPPNLDTSSTFRSSASPPSAFTKAGNEALSVPLSGARNTAASRPTNLAAGNSSASIVQQLLECGGTMGQQKMTSRIRELTERVMHSLMRPVPLDLPHDQKVMIASLIKSAYPMFSRTNQLICLFYCLTGNEEATIQLIQMRHIFKLQLEGLQQGVFTCAPQTLAKIKEKTSRYFAFVKAQLLRLHHEVNNNNMSIQNALAHISSLRTASINQQQQPQPQSQQQQQASQFPQAPSVSSNVRPINGSIPNAQPSVPGQAQPAAKANSVGNTSFPVDSKLAFQSLDVSQPDLQAKQKIASQVMKHGLKPEDLKLPPSKKKKIENLSTVQKPKDSVVNTPDVIMSSVDEIPSSVSPGTIAKEEGMAKAREEAIANPLKYAIDAFVAVDHEEEVSAIKSSQTPSSILKTPQSFFIPPSTPDLSFTDNKNSLSPSNILSLDGKFSFNDDSELWADLGNEINSEIGFLKEPDTMNLALDADKDKTKMQNKLTQINFDESCFLDPAIDDKDPWNEMLHEKKVLLKQLQVGNEDEDNIAFPTSTNIWQVVI