Protein
Uracil-DNA glycosylase
Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987)
Function
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.
Similarity
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
Sequence
MAQLDLTGLTETSKMIVGECHVELKRCAEPPLAADEPMPKKCRRPAGPPKGFISTRGDTSPSSDNNHIHSIQSLTNGDSCVQPWDIIANAYNIHENWKQLLLPELCCLRGSEILAEYERRAITEEVYPPKMDIFAWTRYCAPESVKAVIVGQDPYANPGQAHGLAFSVKQGVAIPPSLKNILLAVKACYPSADLGNHGCLEAWSKRGVLLLNSVLTVKRGDPGSHHSVGWQFFIRNILRRLSSTTRGIVFMLWGAQAQTMYFQTDYDDRHLVLKYSHPSPLSRKPFATCTHFKEANDFLSKIGRGCIDWSLTA