Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987)
Function
Functions as a DNA-binding transcription factor. Promotes transformation, host cell growth, host cell-cycle progression through G1/S phase, and possesses antiapoptotic activity. Forms functional heterodimers with host JUN. These heterodimers bind with high affinity DNA sequences called MEQ-responsive elements MERE I (TGACA/GTCA), while MEQ homodimers bind a second type of sites termed MERE II (ACACA). Both homo and heterodimerization of MEQ are required for oncogenesis.
Similarity
Belongs to the bZIP family. Jun subfamily.
Sequence
MSQEPEPGAMPYSPADDPSPLDLSLGSTSRRKKRKSHDIPNSPSKHPFPDGLSEEEKQKLERRRKRNRDAARRRRRKQTDYVDKLHEACEELQRANEHLRKEIRDLRTECTSLRVQLACHEPVCPMAVPLTVTLGLLTTPHDPVPEPPICTPPPPSPDEPNAPHCSGSQPPICTPPPPDTEELCAQLCSTPPPPISTPHIIYAPGPSPLQPPICTPAPPDAEELCAQLCSTPPPPICTPHSLFCPPQPPSPEGIFPALCPVTEPCTPPSPGTVYAQLCPVGQVPLFTPSPPHPAPEPERLYARLTEDPEQDSLYSGQIYTQFPSDTQSTVWWFPGDGRP