Protein
Negative regulator of sporulation MDS3
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Function
Negatively regulates early sporulation-specific genes (By similarity). TOR signaling pathway component that contributes to morphogenesis as a regulator of this key morphogenetic pathway. Required for growth and hyphal formation at pH 9, for full virulence in a mouse model of systemic infection and for biofilm formation. Involved in chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens.
Sequence
MSTLIPTASACYSLQLPPTEKDDRLNLNVRTGSASTLYNSLIFVHGGLTIGLELLNYTIPELNEIFYNRINISASKYKTVEKYLSGELFYLSLIERNWSRVVLEELEIRPKPRLLHQICAFNNCLYLFGGLALSQENDEDPTLVPCNDLWEFDLVLKKWTLLDDGSNYELDDAVPSPRFNHKLTVISSLSFANRKDHFGLFIAGGKDKQSNEIYDNSIFDLVEKRYVGSQPFRLVATTGDDTKDKETGLNEFVSNPEHFLNVDQTRNAILSITDDADTPNRKQNKNPSNHHESIVVYGPTRQTGDCQNSLVSFKVGKREIKGGKVLRLHKNSRVAKLKQSIIPYNLRYPTAGLFGQNVVLTGFLPDEYEISIFVYNRPTGKWSRLNIFCSHEYGSHRFWGGFAWQSHHKVILIGNSMTSRTTSSVRFFSIMLTVSLPITNILVSSELSKGRSNNRTSSFVSHGEQRHHRNKSQNDSLLKAELSLESTTEDSTDSSSDKTAESVLDAPVPLANSRRQSFSSLGSDKSPTAVSFSDYVHYAAPKTTYTTIRSVFPPEAITLGRNAFNRIGDLIADIELVSCNGDRIPVSSAVLMERWGQHFISLLAKGYINAVDKFETDQALGLDENQRLRSKSSNSESSSSDIPKLKLSLSESLLSSSSGEHDKKEKMGLSSAHKPQKDVPQFRLPFQDSSESVNREEGSDCSKDRKTGGSSVSTAIDPHHVMPRKNSTSSFQSNSSSLLTSHLQDIPPQLPLPDEQIPAVPAAPVSYRSASRKNSQDHSSPRSSLIHTLTVLRNIPVSKSPRESPFSSPRPSMSGPSGGSADLFSSPFPSLKANYGKPPSNLRKKSYDMNDGTIESSLDSFSSGKSSMAKVSSVPGENPDSDESSIGFQEFNKNPISMFDNALLNFDNIDSENFRMEPSLIPRKLYIPFMTLTVKAFCEYLYTGQIGNKWLLAPTLMDNLLISKFYRVPLLYDLISEILFGVIGKKEAYIIGEARKLKARYFKLLRGANIPIDSNYEFPMDEYDGFLDTVDDGYLDITLLKKASKIHADSVAMSLKKKSVTSNNSRNASIRKEGSTTAESVLEEGEKQEEIVSKDDEDESRTGSTSEEDEVDKEYGLVYLEAKDKSLPTIGPRSKSIFDRQGLAAIEKLEEEQNDHQVHSIVEGEDHENLITLDELVASDAPSDYAIDLIFETATLVTDMKMLLRTSNLKAMTAKFRKCKADIEKEMADIEYQLTQMPSGSRNLAMKSANQLKESQLQSKSSPIIPTVSTVTPSPLPSISGVPSPRLPQQQLPEAQLPKLTKSTSSLSRIASHTSFKALRSMTDVTPMEKSTSDKSFRGKLQQTMLSRTPTNRNEDQDSSSASSIKSSSKKRGIFGLLTGLKR