MDR3

Gene

mdr3

Protein

Major facilitator superfamily multidrug transporter mdr3

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)

Length

528 amino acids

Function

Major facilitator superfamily transporter that confers resistance to azoles such as itraconazole.

Similarity

Belongs to the major facilitator superfamily.

Mass

57.042 kDa

Sequence

MLAMAASAEETNRQSNAGRRSVISPSEAPPEAEQSDVYQAPPPGLKEWLFILILCSTQLFVQGAFGYILIPLHIVGQTFGQGPSEATRMTWHVGGYSLTVGTFILIAGKLGDLYGSKRILVLGWAWFGVWSVIGGCSAFTHSPVFFDTARALQGIGPALLLPNALAIAGRTYPPGKKKNMIFSAFAVAAPLGCFTAGVVGSVFAQYVWWPWVMWTYSIGCFIIAAVGLWVIPSDYPRCQKAATLQFDYIGSVLGVAGLLLLNISWNQAPIDGWSTPYVYVLLIGGFLVLGLFELQERRAPGIRSWINFAMCLLWIQQCSSRQGPSQGILPALATPYLMAVITSGWLMAIACAAFLGGCILQSTAPVEQSYWMNTFWSFVIMAWGMDISFPASTTILSDAVPVKHQGASASLVNTVINYSIAIGLGIAGTVEAEVSHQGVNQLRGYRAALWSSVGLAALAFGIALVFAVCTFQEQRSSRKSSQEREQRACIEGCILGLTLTPDREWERVELGRLLSHVSQTGGLRSQSV

Protein

Major facilitator superfamily multidrug transporter mdr3: mdr3

Gene

MDR3

Protein

Multidrug resistance protein 3

Organism

Entamoeba histolytica

Length

114 amino acids

Function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Mass

12.805 kDa

Fragment

single

Sequence

SGCGKSTTIQLVQRVYDPVGGKVTLDGNDLRELNLKWLRNQIGLVGQEPILFACTIRENIMLELKWRTPTEEEMLECAKMANAHEFIFFIFQQGYDTMVGARGAALSGGQKQRI

Protein

Multidrug resistance protein 3: MDR3