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MDM4

Gene
mdm4
Protein
Protein Mdm4
Organism
Danio rerio
Length
496 amino acids
Function
Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
Similarity
Belongs to the MDM2/MDM4 family.
Mass
55.241 kDa
Sequence
MTSLASSSQLPGSCRTLPGEGTQVHPRAPLLQILKVAGAQEEVFTLKEVMHYLGQYIMMKQLYDKQRQHIVHCHDDPLGELLEVGSFSVKNPSPVYEMLKRNLVILNNSDAAKNLSVGKDSNESPSEDPGQVSSGSINSAQPLIAGSSSTGTTQSCSQRRPRDPDEDSSDGLPRSACKRPKLDVTLEEWDLSGLPWWFLGNLRSNYTRRSNGSTDIHTNQLSPGQDEDTAIVSDTTDDLWFLNEAESEQVSVEIKEAVLEQGSDGESPHEDEDTGKDSKDDGKMQEEQEEDSQCLSDDTDTEISTQDAWQCSECRKFNTPLQRYCMRCWALRKDWYKDCPRLVHSISVPDIPACSSRPERDEDEEEEDDDGIDMPDCLRTVSDPVVLPSHRVSRNIPSSSASSSKGKGPSQIHHHFQETSEGDSQDTLDMETEYQPEALLEPCKLCRVRPRNGNIIHGRTAHLITCFPCARKLHKFHAPCPGCGQVIQKVIKTFIA

Gene
MDM4
Protein
Protein Mdm4
Organism
Bos taurus
Length
491 amino acids
Function
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity).
Similarity
Belongs to the MDM2/MDM4 family.
Mass
55.18 kDa
Sequence
MTSFSTSAPCSAPDSARRISPEQTNQVRPKLPLLKILQAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATAATDAAQTLAIAQEHSMDIPSQDHLKQSVEESSNSRKRTEEGNIPTLPTSQYKCKNSREDEDLVANLTQEETSRLDLGFEEWDVAGLPWWFLGNLRNNYTPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNESVSEQFGVGKKVEAADPEQTSEEVGKLIDKKVTEVGKNDDLEDPKSISDDTDIEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKQESEGVDVPDCRRTVSAPVVRPKDTYVKEESSKHFDPCNSVEFLDLAHSSESQETISSMGEQSDNLFEQRKDTENMEDCQNLLKPCSLCEKRPRNGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFVA

Gene
MDM4
Protein
Protein Mdm4
Organism
Homo sapiens
Length
490 amino acids
Function
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Similarity
Belongs to the MDM2/MDM4 family.
Mass
54.864 kDa
Sequence
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA

Gene
Mdm4
Protein
Protein Mdm4
Organism
Rattus norvegicus
Length
490 amino acids
Function
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity).
Similarity
Belongs to the MDM2/MDM4 family.
Mass
55.221 kDa
Sequence
MTSHSTSAQCSASDSACRISSEQINQQVRPKLQLLKILQAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHLVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVTSASVNTDAAQTLALAQDHTMDIPSQDRLKHGATECSNPRKRTEEDDTHTLPTSRRKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNYIPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGVKVEAANCEQPSEVGRTRDKKMVEGGKDDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSVEFLDLAHGSESQEIISSTREQTDIFSEQKTETESMEDFQNVLKPCSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA

Gene
Mdm4
Protein
Protein Mdm4
Organism
Mus musculus
Length
489 amino acids
Function
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform.
Similarity
Belongs to the MDM2/MDM4 family.
Mass
54.963 kDa
Sequence
MTSHSTSAQCSASDSACRISSEQISQVRPKLQLLKILHAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVTSASINTDAAQTLALAQDHTMDFPSQDRLKHGATEYSNPRKRTEEEDTHTLPTSRHKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNCIPKSNGSTDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGIKVEAANSEQTSEVGKTSNKKTVEVGKDDDLEDSRSLSDDTDVELTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSVGFLDLAHSSESQEIISSAREQTDIFSEQKAETESMEDFQNVLKPCSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA

Gene
mdm4
Protein
Protein Mdm4
Organism
Xenopus laevis
Length
475 amino acids
Function
Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
Similarity
Belongs to the MDM2/MDM4 family.
Mass
53.405 kDa
Sequence
MSTSTALHLMDEQDPAPTTIQNTEESLVRVQPALLKILQSAGAKGDMFTLKQVMHYLGQYIMVKGLYDKQHQHIVHCGSDELGKLLGITTFSVKDPRPLYDMLKKNLLRISCTDAGHSPSRNKSQASDSLELEKSFASKTEVTDVIKRNDCVSSDMCTSFDNSHLKGNESSDYTKQSLDFIFEEWDEAGLPWWFLGNLRTNYNLQSIGSTDIPSNQDIDTATVSDTTDDMWFLNDSRTDRINMEVKMESSDSLEEEVGECDSKKPAQMIELTLYEDDDDLDDTQSLSEDTDTEVTSEECWQCTKCHKFNSPVKRYCYRCWALRKDWYLDFPRLIHSSSTPTLPGKVSSQMIVDGLDIPDCRRTVSAPMVGVQVPECRSLVPFLEPLDLAANSKAFSESTDTLLTFKAAEASLLSSRPLLEPCQLCQRRQRNGSVVHGRTAHLVTCFSCACNLKKNQKGCPVCEKPIQMVVKIYVA