Protein
N-terminal acetyltransferase B complex subunit MDM20
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Function
Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions. MDM20 is required for mitochondrial inheritance during budding and together with TPM1, is essential for the integrity and assembly of actin cables. Genetically interacts with CIN8.
Similarity
Belongs to the MDM20/NAA25 family.
Sequence
MSDKIQEEILGLVSRSNFKQCYAKLGQLQKQFPNALYFKILETYVKFKQSPGKFDYNKLLEEPYGLKGTTITGDTRSLEFLHNFFVELGKYDEALHVYERGNFKFPSYELSYHWFMKALEDSNYNQMSKASLQLAKYSDSGNLPKRAYYFWNAISILAVSRFQENTLSDPKKILLSRLARQSLLDLKPFQNVQEIIVYCLVLDELFPQSREISEEIVAITFANFDTSVNLYLKNFILKHTKLLNSPQKLFEVCSKLIEKGLDDYELITNLIDAAYKLSKSKDEVKQWIDENLGDSRNTRLARLKLDIMYTDSVSESSLSYYLSKYHNKPCCSIDLNHYSGHINIDMLKSIMSKYDPEDKDLIHHCNILELGLIGSDSINNYNKFKGTLEKKSVTDYSSCSTFLLEIVKDKCKKTNPELKDVLLCITILENYQAKDPHNFDTMCWLIVLYMYLGLVPDAYFHFINLKIKNVQTDSLDYMIFSRFSTLFPNKQSDFYSKTFHEHNNLYDTSLANLPRYIQVAFERNSYSKILGMLEMRDKLMKSYTRWTKTLENLQFSRLCNDKRGHLLQKLHEDWRSLEMTQSVSFSDNRDFSILDENFAQFLNRGKILEYANLNEESIFLTLIRELIIEALPNGEKTEQISALLKKLPSINLEELLNNNLTEVESASFLIFFEIYENNGKNLHDLISRLMKVPINAKQNWMVSHTYLTKMATLKTLDSLKRIKDKEIQKLIKNSLKELRSCCDDVFKGYSKALVQAYEELKKDECGNLLKELDVKAENVKNIKNSLLGIQKSVRNL