Protein
Pentafunctional AROM polypeptide
Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)
Function
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
Similarity
In the C-terminal section; belongs to the shikimate dehydrogenase family.
Sequence
MEQPTTIQILGRDSIVADFGIWRRHVARDLLETLSSSTYILISDTNIAPLYVPEFERAFEEAAAEKSPKPRLLTYKIAPGESSKGRETKAEIEDWMLSCQPPCGRDTVLIALGGGVIGDLAGFVAATYMRGIRFVQVPTTLLAMVDSSIGGKTAIDTPNGKNLIGAIWQPEKIYLDMEFLNTLPQREFTNGMAEVIKTAAISSETTFAELEQNADAIAAALKTENTPERSRFSGIQEILKRTILASARFKADVVSKDEREGGLRNLLNFGHSIGHAIEAILAPQILHGECVAIGMIKEVELARYLGILKGAAVARLAKCLTRYGLPTSLKDARIRRLSAGKKCPVDKLIAFMAVDKKNDGPMKKVVLLSAIGRTHEQKASVVSNEELKVVLAPSIEVLPGIPKPLNVTCTPPGSKSISNRALVLAALGSGVCRIRNLLHSDDTEVMLNALEALGAATFSWEEEGEVLVVNGKGGKLEASAHELYLGNAGTASRFLTTVATLSNEKDDVSHNILTGNARMKQRPIGDLVDALKSNGVSVDYLEQQGSLPLKVPACGGFKGGAIELAAKVSSQYVSSLLMCAPYAKEKVTLKLVGGKPISETYIAMTAAMMKSFGIDVEKSTTEEYTYHIQQGQYKNPPEYIIESDASSATYPLAIAAMSGTTCTIPNIGSKSLQGDARFAVDVLRPMGCDVKQTNSSTTVTGPTNGALKPIANVDMEPMTDAFLTASVLAAVANDKSGNTTRIYGIANQRVKECNRIKAMKDELAKFGVTCREHDDGIEIDGIDSSELKVPVNGVHCYDDHRVAMSFSVLAAAAASQPTLILEKECVGKTWPAWWDALAQTFKVKLDGKELVNDNVVDIQKSTKSIASIFIIGMRGAGKTTSGYSISKALNRPFIDLDTELENVEGMPIPEIIKQKGWEGFRDAELALLKRMMAEKPTGYIFACGGGIVETKEARDLLINYHKNKGNVFLIMRNIKKVIEFLEIDKTRPAYIEDMMGVWLRREPWYQECSNLQYYSHHSERSELDAALQGFTRFLNVVMGNTDHLALLKKKDHSFFVSLTLPDLQLSADILRAATFGSDAIELRVDLLKDPSSTSGVPSVGYVAEQMSFLRSHASQPLIFTIRTKAQGGQFPDDAVDKALELYKLAIRMGSEFVDLELSFPNDLLHAVTEMKGFSKIIASHHDVNSQLSWSNGSWIQYYNKALQHGDIIKLIGVAKTFEDNMALQQFKSWAEKSYPVPIIAINMGNKGRLSRILNRFMTPVSHPALPFKAAPGQVSAKDIRQALTLMGELDAKKFALFGKPISASRSPALHNALFTQAGFPHDYGLLETDKAENVEKFIRSDDFGGASVTIPLKEQIMGLLDEISPEAKIIGAVNTIVPITVSGRPPRLIGYNTDWQGMARCLKDAGAICSNNGESALTIGSGGTARAAIYSLHSMGYSPIYLVGRTPSNLSKLASSFPAEYNIQVVQDIKSVQAAPKVAISTIPGDQELENPLPELITQIMEKGQDSSRECILLDMAYKPDVTTMARLASPAGWKIIKGLEVLVAQGIYQFEHWTGLMPIYEDARAAVMNI