MBNL3

Muscleblind-like protein 3

354 amino acids

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.

Belongs to the muscleblind family.

38.532 kDa

MTAVNVALIRDTKWLTLEVCREFQRGTCSRADADCKFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKTAAAMFAQQMQLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPPLAMPGAVGPKLMRSDKLEVCREFQRGNCTRGENDCRYAHPTDASMIEASDNTVTICMDYIKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKPNGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAATTPATSVPFAAPTTGNQLKF

Mbnl3

Muscleblind-like protein 3

342 amino acids

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins (By similarity). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.

Belongs to the muscleblind family.

37.57 kDa

MTPVNVALIRDTKWLTLEVCREFQRGTCSRADAECRFAHPPRVCHVENGRVVACFDSLKGRCTRENCKYLHPPPHLKSQLEVNGRNNLIQQKTAAAMFAQHMQLMLQNAQMSSLASFPMNPSLAANPAMAFNPYMTHPGMGLVPAELLPNGPVLISGNPPLALPGVPGPKPIRTDRLEVCREFQRGNCTRGESECRYAHPTDVSMIEVTDNSVTICMDYIKGRCSREKCKYFHPPPHLQAKLRAAHHQMNHSAANAMALPHGALQLIPKRSALDKANGATPVFNPSVFHCQQALANMQIPQQAFIPTVPMMHGATPSTVSTATPPASNVPYVPTTTGNQLKY

mbnl3

Muscleblind-like protein 3

323 amino acids

Involved in pre-mRNA alternative splicing regulation. Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction (By similarity).

Belongs to the muscleblind family.

35.482 kDa

MAVNMTMGRDTKWLTLEVCREFQRGTCSRSDAECKFAHPSRSCHVENGRVIACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKAAAAMLAQQMQFMLPGAQLQPITTFPMTHSLATSPSMAFSPYLNHMGPGMGLMPELLPSTPLLVPGSPTGLAAMSNGTSSPKHMRTDKLEVCREFQRGNCTRGESDCRYAHPLEAGMVDSSENSVIVCMDYIKGRCSRDKCKYFHPPAHLQARIKASQHQASQNTASAALSPPAGTMQLLPKRPVLEKSNGAVAGIFNPSMFHYQQALANMQLQQPAFIPTGEWCSGVVTLC