Protein
[Methyl-coenzyme M reductase subunit alpha]-arginine C-methyltransferase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Function
Radical SAM methyltransferase that is responsible for the C(5)-methylation of 'Arg-285' of the methyl-coenzyme M reductase (MCR) subunit alpha McrA. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR.
Similarity
Belongs to the radical SAM superfamily. MCR alpha subunit C-methyltransferase family.
Sequence
MEVVVDVGGNPGVDCKGFCKYCYFKKVKDIQPLGCKYCLPFKKGCDYCTRSVKESYSGFKSLQMVLEETANKLYFTSGEVKKFTVSGGGDLSCYPELKSLITFLSQFNTPIHLGYTSGKGFSKPDDALFYIDNGVTEVSFTVFATDPALRAEYMKDPEPEASIQVLRDFCTHCEVYGAIVLLPGINDGEVLEKTLCDLENMGAKGAILMRFANFQENGLILNNSPIIPGITPHTVSEFTEIVRSSAEKHPSIRITGTPLEDPLIGSPFAIRNVPEALLKLPRVSKKATIITGQVAASRLTEIFEALGGTVNVIPVKKDIGCLITIDDFKALDLSEVTETVFIPGRAFVHDMEIKEALRRDGVDRIVRRGPERLSVDGEMSIGMTREEVLELEVENFTELIGQINSLGLPLE