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MARCKSL1

Gene
Marcksl1
Protein
MARCKS-related protein
Organism
Mus musculus
Length
200 amino acids
Function
Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (PubMed:22751924). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (PubMed:22751924). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (Probable).
Similarity
Belongs to the MARCKS family.
Mass
20.165 kDa
Sequence
MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVRSNGDLTPKGEGESPPVNGTDEAAGATGDAIEPAPPSQEAEAKGEVAPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEMSACSDEGTAQEGKAAATPESQEPQAKGAEASAASKEGDTEEEAGPQAAEPSTPSGPESGPTPASAEQNE

Gene
MARCKSL1
Protein
MARCKS-related protein
Organism
Oryctolagus cuniculus
Length
199 amino acids
Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (By similarity). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (Probable).
Similarity
Belongs to the MARCKS family.
Mass
19.766 kDa
Sequence
MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLTPKGEGESPPVNGTDEAAGATGDAIEPAPPSQGAEAKGDAPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSEEGTAPEGKAAATPESQEPQAKGAEAGAACKGGDTEEEAGPPAEPSTPSGPESGPTPAGAEQNE

Gene
Marcksl1
Protein
MARCKS-related protein
Organism
Rattus norvegicus
Length
199 amino acids
Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Similarity
Belongs to the MARCKS family.
Mass
19.847 kDa
Sequence
MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLTPKGEGESPPVNGADEAAGATGDAIEPAPPSQEAEAKGEVAPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEISACSDEGTAQEGKAAATPESQEPQAKGAEASAVSKGGDAEEEAGPQAAEPSTPSGPESGPASASAENE

Gene
MARCKSL1
Protein
MARCKS-related protein
Organism
Bos taurus
Length
198 amino acids
Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Similarity
Belongs to the MARCKS family.
Mass
19.825 kDa
Sequence
MGSQSSKAPRGDVTAEEAAGASPAKVNGQENGHVKSNGDLSPKGEGESPPVNGTEEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEISACGEEGTAQEGKAAATPESQEPQAKGAEASAAAKGGDTEEAGPQAAEPSTPSGPESDPAPASEQNE

Gene
MARCKSL1
Protein
MARCKS-related protein
Organism
Homo sapiens
Length
195 amino acids
Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).
Similarity
Belongs to the MARCKS family.
Mass
19.529 kDa
Sequence
MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVKSNGDLSPKGEGESPPVNGTDEAAGATGDAIEPAPPSQGAEAKGEVPPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGKAAATPESQEPQAKGAEASAASEEEAGPQATEPSTPSGPESGPTPASAEQNE