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MAP3K21

Gene
MAP3K21
Protein
Mitogen-activated protein kinase kinase kinase 21
Organism
Homo sapiens
Length
1036 amino acids
Function
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Similarity
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Mass
113.957 kDa
Sequence
MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQMKDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTESALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSLPSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAYPQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELEKEFLS

Gene
Map3k21
Protein
Mitogen-activated protein kinase kinase kinase 21
Organism
Mus musculus
Length
1002 amino acids
Function
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity).
Similarity
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Mass
110.112 kDa
Sequence
MALPVAEGTADTPLSPARDDSGSTSSGMWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPASYVAPCGPVPPPAPPPPRPCSPVHVDFERLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTRMSAAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTAIEEAVLTNMPQESFHSMQEDWKLEIQQMFSELRTKEKELRSREEELSRAALQQKSQELLLRRREQQLAEREIDVLERELNVLIFQLSQEAPHVKKRKGRFRRGRLRLKDGHRISLPSDFQHKITVQASPTLDKRRSSDSGLCSPPGSPLMLPRLRAIQLTSDENNKTRGRNMVFRQEDFEDVKRSFKKKGCTWGPSSVQTKERPEGRERVRPLSDGNSPWSSLLIKSQKTTPLASLFVDQPGSCEEQKLVPEGLEHRKPKQTKFPGQAHVGLPLCKDSQREDSSEAESREEGSPKGSPVNNVGAPMLRKKTESALCECGMLLASMALGLDVRKLHGAQAPAKPSPKMEKKEEGALQPASRCQSSPSSLLRQPSAGRAPSGGSTLLLPSAPSHSSKSSLSMKCLLQAGKEESSLGNARDLCGPTTLTPDPGSAAPESGCELIPGLRPKTDYGVLRSMPHAILEQTGERLPGCAIVGDKGCHHMQMGSEETPLWLQSAPEDSGLPHSPSPGPQRDLASQASLVKPEGVLGECQACPALPQRPHTASVRTTSPPTWVCDKDHQVPALACLLGAQERSRCQTPSLLDASIEGQKKDCAMPLCRVKSVMCQPSIYALEKDFLT