MAMLD1

Gene

Mamld1

Protein

Mastermind-like domain-containing protein 1

Organism

Mus musculus

Length

803 amino acids

Function

Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ (By similarity). Required for testosterone production.

Similarity

Belongs to the mastermind family.

Mass

87.598 kDa

Sequence

MDDWKSRLVIENMLPHFNMVGNRQETRKLQESGTSKRRQEGENFHFTGMADGSYPNKIKRPCLEDVTLSMGPGAHPTSLSTEMQMPTLNMNPTSADLGVAGQSLLLENNPLDSNVVNSSAMGSPFGVPSTADTGLKGHAVPYYEKNNSMPAVDQELQDLLEELTKIQEPSSNDLDLEKILGSKPEEPLVLHNPQAPLGPPAKLPVQMPHMESLGSSKEFASSCSQVAGTSLPIMPSSTGMSYSIPSSSKQIVSSSSSTAQAQVKNQVQNMLPVTMPPLSVPQWHHAHQLKALAASKQGSATKQGSNRNWSSLPPPGLSPPYLPVPSPHPPPPQPPPPPFSPQNFTASCMSSSSLSGSAVQSSPNALLSSMAPSSNASLGPTLPYVPAKLPGLPLNQQPQFSPQSSILANLVSSSVKSPQGHLISALPTSTPGPSPPYRPENLSSPGLPQQSFTPQYSLIRSLTPTSNLLSQQQQQQQQQQQQQQQQQQQQQQQQHQANSIFKPMTSSQQPKTLSMIMQQGLSSSSPEAPEPFTFSNTKPLSHFVSEPSPQKMASMSTHSRQSSLLHYLPQATPAHAPSATASSTATATLQLQHHHQQHHHQQHHHQQQHHQQQHHQQHHHQQQQHQQQQHQQQQQQQPDQSSFLLQQIMQQPQRFQRMMASDSMPALPGQGCCHRCAWTSTALWLEHQHQQWNSLTSTHGHVPPSNLTHVDKACKLGEARPPHVSLGRQPPSRQALGSESFLPGSSFAHELARVTSTSSYNTSEAAPWGGWDPKAWRQVPAPLLPSCDAAAREAEIRSYGNDP

Protein

Mastermind-like domain-containing protein 1: Mamld1

Gene

MAMLD1

Protein

Mastermind-like domain-containing protein 1

Organism

Homo sapiens

Length

774 amino acids

Function

Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.

Similarity

Belongs to the mastermind family.

Mass

83.231 kDa

Sequence

MDDWKSRLVIKSMLPHFAMVGNRQEPRKLQESGKKPSWMEEEDLSFLYKSSPGRKHQGTVKRRQEEDHFQFPDMADGGYPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELARVTSSYSTSEAAPWGSWDPKAWRQVPAPLLPSCDATARGTEIRSYGNDP

Protein

Mastermind-like domain-containing protein 1: MAMLD1