Protein
Mastermind-like protein 2
Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 (By similarity).
Similarity
Belongs to the mastermind family.
Sequence
MGDTAPPQAPTGGLGGAPGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATASTATATAPPPAPAAPPTASQTAAPAAPAPPPDYHHHHQQHLRSSSSSGGSGGIDGEQQQQPPASTPGDQRNSALIALQGSLKRKQIVNLSPANSKRPNGFVDNSFLDIKRIRVGENLAAGPGGLPVNNGQSQMMSGTLPMSQVPLRKTAALPPPPTHSPGNGLFNMGLKEVKKEPGETLSCSKHVDGQVTQENIFSNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPLEKTVIKSEYSPGLTQGPSGSPQLRPSSAGPAFSMASSGLSASSPIPSVPQSQAQPPPATGAARALPSWQEVSHAQQLKQIAANRQQHVRMHQQQQQHQPTSWPALPSSAGPSPGPFGQEKIPSPSFGQQPFSPQSTPMPGVTGGSNQSKVMANYLFKASPSAQGGPLDVLLQPKPQDLSRSFLNNPHPAMEPRHGSTKPLFHFNSDQANQQMPSVLPSQSKPSLLHYTQQQPQQSSITVQPQQQQQQPQQQQQPQQQQQPQPQQQQQQQPQAQQPAAQPTQPLSNQPLLRAPLPLQQKILLQKIQNQPITGLGYQVSQQHRQDQHSVVGQNAGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLTRPPPDYKDQRRNVGNMQPTAQYSGGSSTVSLNSNQALANPVSTHTILTPNSSLMSTSHGTRMPSLPTAVQNIGIYGNLPCSQPSTYSVTSGMNQLTQPRNPNQLIANQNNPLMPRPPTLGPSNNNNNNVATFGAGSVGNSQQLRPNLTHSMASMPAQRTSNVMITSNTATPNWASQEATAKQQEALKSAGVRFPTGTTTAYAPNQSLQQAVGSQQFSQRAVAPSNQLTPAVQMRPMNQMSQTLNGQNMGPLRSLNLRPNQLSTQLLPTMNQAGTGLSQSRTVSQPPSLAAGGFPSPNQSSRAFQGTDHGNDLAFDFLNQQTDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS