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MAFA

Gene
Mafa
Protein
Transcription factor MafA
Organism
Rattus norvegicus
Length
361 amino acids
Function
Transcription factor that activates insulin gene expression (PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (By similarity). Binds the insulin enhancer C1/RIPE3b element (PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity).
Similarity
Belongs to the bZIP family.
Mass
37.78 kDa
Sequence
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGSSAGGGGSAAQAGGAPGPPSGGPGTVGGASGKAVLEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHSAHHGAHHPAAAAAYEAFRGQSFAGGGGGGADDMGAGHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGAGHGGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGGAGGAGFPREPSPAQAGPGAAKGAPDFFL
Protein
Transcription factor MafA: Mafa

Gene
Mafa
Protein
Transcription factor MafA
Organism
Mus musculus
Length
359 amino acids
Function
Transcriptional factor that activates insulin gene expression (PubMed:12368292, PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15665000). Binds the insulin enhancer C1/RIPE3b element (PubMed:12917329, PubMed:14680841, PubMed:14973194, PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity).
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
37.576 kDa
Sequence
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGAGGGGSAAQAGGAPGPPSGGPGTVGGASGKAVLEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGQSFAGGGGADDMGAGHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGAGHGGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGGAGGAGFPREPSPAQAGPGAAKGAPDFFL
Protein
Transcription factor MafA: Mafa

Gene
MAFA
Protein
Transcription factor MafA
Organism
Homo sapiens
Length
353 amino acids
Function
Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435). Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959). Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498).
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
36.982 kDa
Sequence
MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCSSVPSSPSFCAPSPGTGGGGGAGGGGGSSQAGGAPGPPSGGPGAVGGTSGKPALEDLYWMSGYQHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGPGFAGGGGADDMGAGHHHGAHHAAHHHHAAHHHHHHHHHHGGAGHGGGAGHHVRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVEQLKLEVGRLAKERDLYKEKYEKLAGRGGPGSAGGAGFPREPSPPQAGPGGAKGTADFFL
Protein
Transcription factor MafA: MAFA

Gene
mafA
Protein
Adhesin MafA
Organism
Neisseria gonorrhoeae
Length
320 amino acids
Similarity
Belongs to the MafA family.
Mass
34.779 kDa
Sequence
MRARLLIPILFSVFILSACGTLTGIPSHGGGKRFAVEQELVAASARAAVKDMDLQALHGRKVALYIATMGDQGSGSLTGGRYSIDALIRGEYINSPAVRTDYTYPRYETTAETTSGGLTGLTTSLSTLNAPALSRTQSDGSGSRSSLGLNIGGMGDYRNETLTTNPRDTAFLSHLVQTVFFLRGIDVVSPANADTDVFINIDVFGTIRNRTEMHLYNAETLKAQTKLEYFAVDRTNKKLLIKPKTNAFEAAYKENYALWMGPYKVSKGIKPTEGLMVDFSDIRPYGNHTGNSAPSVEADNSHEGYGYSDEAVRQHRQGQP
Protein
Adhesin MafA: mafA

Gene
mafa
Protein
Transcription factor MafA
Organism
Xenopus tropicalis
Length
289 amino acids
Function
Transcription factor, possibly involved in transcription regulation during lens development.
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
33.146 kDa
Sequence
MASDLAMSAELPNSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPISTPCSSVPSSPSFCAPSPGAQSGVNPSNPNAANKPQLEDLYWMSNYQHHINPEALNLTPEDAVEALIGNPHHHHHHHQGYDGFRGQQYPGDEMAPSGHHHQVHHHHHHHNHHLRLEDRFSDEQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRYKRVQQRHILETEKCQLQSQVEQLKQEVSRLAKERDLYKDKYEKLASRSFTTRESPPQGNPGKANADFFM
Protein
Transcription factor MafA: mafa

Gene
MAFA
Protein
Transcription factor MafA
Organism
Gallus gallus
Length
286 amino acids
Function
Transcription factor involved in transcription regulation during lens development, including that of crystallin and filensin/BFSP1 genes (PubMed:9525857). Binds to CRE-type MARE 5'-TGCTGACGTCAGCA-3' and TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequences (PubMed:12970735).
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
32.445 kDa
Sequence
MASELAMTAELPTSPLAIEYVNDFDLMKFEVKKEPAEAERLCHRLPAGSLSSTPLSTPCSSVPSSPSFCAPSPGGQPSAGPTAAPLGSKPQLEELYWMSGYQHHLNPEALNLTPEDAVEALIGAPHHHHHHHQSYESFRPQPFGGEELPPAAHHHNAHHHHHHHHLRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQNRRTLKNRGYAQSCRYKRVQQRHILENEKCQLQSQVEQLKQEVSRLAKERDLYKEKYEKLAARGFPREPSPPAAPKTTAADFFM
Protein
Transcription factor MafA: MAFA

Gene
MAFA
Protein
Transcription factor MafA
Organism
Coturnix japonica
Length
286 amino acids
Function
Transcription factor involved in transcription regulation during lens development, including that of crystallin genes (PubMed:9674710, PubMed:15963504, PubMed:18042454). Binds to CRE-type MARE 5'-TGCTGACGTCAGCA-3' and TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequences (PubMed:9674710).
Similarity
Belongs to the bZIP family. Maf subfamily.
Mass
32.464 kDa
Sequence
MASELAMTAELPTSPLAIEYVNDFDLMKFEVKKEPAEAERLCHRLPAGSLSSTPLSTPCSSVPSSPSFCAPSPGGQPSAGPTAAPLGSKPQLEELYWMSGYQHHLNPEALNLTPEDAVEALIGAPHHHHHHHQSYESFRPQPFGGEELPPAAHHHNAHHHHHHHHLRLEERFSDDQLVSMSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRYKRVQQRHILENEKCQLQSQVEQLKQEVSRLAKERDLYKEKYEKLAARGFPRETSPPAAPKTTAADFFM
Protein
Transcription factor MafA: MAFA