MAC1

Gene

mac1

Protein

Membrane-anchored protein 1

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

756 amino acids

Function

Required for correct cell separation at high temperatures.

Similarity

To yeast YOL019W and YMR063W.

Mass

81.716 kDa

Sequence

MIRNTLAFLAILFLLIPTALLIIGSVSVPSTRMTLAKVEGTEFGIFGTCTGNGTDCTETSFGYNASSSLIDDFYYKGDKRLVLSKVLITHIISAFLSFLSAIFVFFSIFLVNQAVNIINIIVVFITTLLTCLAFAIELVLFLPHNTWQSYVTAGAIGSDLIAILALCLRSVSISRIGQKSARLEHVDTMNSSYSSYKTDVKYPLALDDKLSSVPTLPKFHDALTSTSEFGPPSDSGDTVGTTQYPGDIKYATGYESTVASPVPSRVAKLSSRDTPSIIADYDEFRKSESSPSRSSVLSTSKPEVHETEGYCPHKTGNRPGFPSLNIPRTRPTTAGIANTQFDLEPYRNRQAGSISSEGTDSRFFDVENQVSVAQTPSVKPEMFPKTARPFAAIHANASSTQLRNTENITHPGIPNHFAKTTSSVFDEPPATRMPQTRSPVNDHSSFPSDLPIKGEMSTNMTGAPRVGSRNNSSNDLHAQAGMLKNVGNGPRNAPRNNSSNNLHAQGGMPMNMRGPRGAPRNNSSGDLHIQSGMPMNGRNGPRDTSRNNSSSDLYAQSGMHPNMNNGHRGAPRNNSSNDLHAHGGMPVNMRGPRNTSRNNSSSEFNAQIPMNLRNGPRNASRSNSSTDLFGQSGIPGNSRGMPTSPNSRNNSALDLSMHGIPLANNSRQFKRPSYGNMSRPSFELNGSRNPSHGSLNTAHAGMGYGPRSMMRDPQNLSNVPPVSNTLDQLSGNADFELPVRGNRNNRRGPGGNRMIR

Protein

Membrane-anchored protein 1: mac1

Gene

MAC1

Protein

Metal-binding activator 1

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

431 amino acids

Function

Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth.

Mass

47.737 kDa

Sequence

MILIDDIKYACMECVRGHRSSSCKHHERPLLQVRSKGRPGVYANGNPNHRVAIFAEEIAKSDKPSTNGTKRCKSEPIIVLKASSKQVIDCSSGVIIGPYDETKTKPSTVEKRTPSPPIISDESFINTSACCTPKISKGKSCGCCNNKRKAVNKSKILQNYIKNKLNQKINNNETLVFMNKSHTTNNEQKEDHQLYGMVPVPSCSIPGTCCCDDACSCQGCVVHGNSKYQIPLPTSKQQVTDTTNPFENEEKFIFNSMPQTDKSDLFFNTISTSSNVPPADSSSECSCPPNACDCTNCETHGILNGFRLDDYFKDQSKLMNVLDFNFSELLGTIPEQPIPTEFMQPPSENTLLTSLSSENSFIPNQTKELSTQPPILPLDAQNVCNELDQLEPLVPSLQPCDKKATKWVNNRDTLEDVSDNRVKSCCSKKTK

Protein

Metal-binding activator 1: MAC1

Gene

MAC1

Protein

Metal-binding activator 1

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

417 amino acids

Function

Regulatory protein involved in Cu/Fe utilization and stress resistance. Involved in basal level transcription of FRE1 and H(2)O(2)-induced transcription of CTT1. Regulates the transcription of CTR1 and CTR3 via the copper ion responsive elements in their promoters. Required for degradation of CTR1.

Mass

46.516 kDa

Sequence

MIIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPSPMAIRDAILVDSTSQSTEYENGAQIEGDCCSAMNQQPILFVRASAVRKARMINGKLHILMEEGFTAHEPKDISTFTDDGNKYITETEFLRKHSPKAPATGTISPDSTKSSSSSEKKERSRLQQEPIRHFSNCCKKDKSQNPASNGKTNKAPSDDIFTPYGSLESTSAFNDILQENYNSSVPGAHDSSETLTPQSTTTIAAPHSSDVASKVEVLTHKGIFLSTQCSCEDESCPCVNCLIHRSEEELNSYIQQSGVPLTNIGEAQITDKMMDYLDDCKCTDKECICPPDNCTCDGCFSHSTNIIPFEKFFFYGILNARLTRKTQIKFKGKLVPSKYWWDFLKLQVPLMTDAQLELLDIHAWFQKLVSNYAPHLSDATTS

Protein

Metal-binding activator 1: MAC1