Protein
dITP/XTP pyrophosphatase
Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Function
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Sequence
MKILVASRNPKKLAELSRVLESSGVSGVELVSLTDVPEYEEVPETGASFEDNALIKAREGVKHTGLACVADDSGLAVDALNWMPGVLSARWSGRHGDDAANTALLLAQLSDIPDERRGAAFVSACALVTPEGEEVVVEGRWKGSIARIPAGQNGFGYDPIFVPRGGLRTAAELTPEEKDAVSHRGRALAALLPMLRNLVNLGRTAP