Protein
Leukocyte immunoglobulin-like receptor subfamily B member 3A
Organism
Rattus norvegicus
Function
May act as receptor for class I MHC antigens. Becomes activated upon coligation with immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Sequence
MTFTFTALLCLGLTLGLWIPVLTGSLPKPILRVQPDSVVSMGTTVTFICEETIGAKQSYLYRNGNLQRRVPKNNQKPTNKTEFLFLNVGHQNAGQYHCSYKSQGKSSDYSEPLELVVTGAYSKPSLSAQTNPVVTSGGYVTLKCEPSHYGHTLILTVEGPQKLSWRQDPQCNYYTENCHVLFYVGPLTSNQRWIFRCYSYETNTPQVWSAPSEPVEILVSGKLQKPTIKAEPGSVIHSGKAMIIWCQGDLDAEIYFLHKEGSHNTQSTQTLQQPGNKAKLFIRPVTQGHAGDYRCYYYSSAGWSEPSDTLELVVTGIYNYHPLMLSGPPSPVVPEGGNVTLHCTSHRYYDKFILIKEDQKFSSSLDTKYISSTGQHQALFVMGPMTPNYSGTFRCYGYYKHTPQLWSEPSNLLKILITGQLHHVLFLSVMPNSTVHSGENVTLMCWSTYSVDTFILSKEGSGQPPLRLKSKIQDQQYQSEFSMSGVTSKLSGTYRCYGSHDSSLYLLSFASAPVELIVSGPIRTSDLPPTMSIPPDGLQRYLKALIGVSVAFLLFLFILIFILLRRRHQEKFRKDDEDAQKGKELQLSTGAAEPVTRDRGHQKRSNPAAATQEESLYASVEDMETKDGVELDTWKPPEGDPQGETYAQVEPSRLRRAGAISPVVSREQLNTKYEQAEEGQEVDSQATESEEPQDVTYAQLCSRTLRQGTAAPPLSQAGEAPEEPSVYAALATARPGAVPKNKKQ