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Lfng

Gene
LFNG
Protein
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Organism
Bos taurus
Length
380 amino acids
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning.
Similarity
Belongs to the glycosyltransferase 31 family.
Mass
41.847 kDa
Sequence
MLKRCGRRLLLALAGALLACLLVLTADPPPPPVPAERGRRALRSLAGPSGVATAPGLEAAAAAAPGAPVREVHSLSEYFSLLTRSRRDVGPPPGGAPRPADGPPRPLAEPLAPRDVFIAVKTTKKFHRARLDLLLETWISRHEEMTFIFTDGEDEALARRTGHVVNTNCSAAHSRQALSCKMAVEYDRFIESGRKWFCHVDDDNYVNVRALLRLLGSYPHTQDVYLGKPSLDRPIQATERVSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFMSTAERIRLPDDCTIGYIVEALLGVPLVRCGLFHSHLENLQQVPASELHEQVTLSYGMFENKRNSVHIKGPFSVEADPSRFRSVHCHLYPDTSWCPRSAIF

Gene
LFNG
Protein
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Organism
Homo sapiens
Length
379 amino acids
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity).
Similarity
Belongs to the glycosyltransferase 31 family.
Mass
41.773 kDa
Sequence
MLKRCGRRLLLALAGALLACLLVLTADPPPPPLPAERGRRALRSLAGPAGAAPAPGLGAAAAAPGALVRDVHSLSEYFSLLTRARRDAGPPPGAAPRPADGHPRPLAEPLAPRDVFIAVKTTKKFHRARLDLLLETWISRHKEMTFIFTDGEDEALARHTGNVVITNCSAAHSRQALSCKMAVEYDRFIESGRKWFCHVDDDNYVNLRALLRLLASYPHTRDVYVGKPSLDRPIQAMERVSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFMNTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTSELHEQVTLSYGMFENKRNAVHVKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIF

Gene
Lfng
Protein
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Organism
Mus musculus
Length
378 amino acids
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (PubMed:28089369). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (By similarity). Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-forming territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity (PubMed:10330372). Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B-cell development in lymphoid progenitors (PubMed:11520458). May play a role in boundary formation of the enamel knot (PubMed:12167404).
Similarity
Belongs to the glycosyltransferase 31 family.
Mass
41.952 kDa
Sequence
MLQRCGRRLLLALVGALLACLLVLTADPPPTPMPAERGRRALRSLAGSSGGAPASGSRAAVDPGVLTREVHSLSEYFSLLTRARRDADPPPGVASRQGDGHPRPPAEVLSPRDVFIAVKTTRKFHRARLDLLFETWISRHKEMTFIFTDGEDEALAKLTGNVVLTNCSSAHSRQALSCKMAVEYDRFIESGKKWFCHVDDDNYVNLRALLRLLASYPHTQDVYIGKPSLDRPIQATERISEHKVRPVHFWFATGGAGFCISRGLALKMGPWASGGHFMSTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTTELHEQVTLSYGMFENKRNAVHIKGPFSVEADPSRFRSVHCHLYPDTPWCPRSAIF

Gene
Lfng
Protein
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Organism
Rattus norvegicus
Length
378 amino acids
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning.
Similarity
Belongs to the glycosyltransferase 31 family.
Mass
41.958 kDa
Sequence
MLQRCGRRLLLALVGALLACLLVLTADPPPTPVPAERGRRALRSLAGSSGAAPGPGSRAAVDPGVLVREVHSLSEYFSLLTRARRDADPPPGVASRQGDGHPRPPAEVLSPRDVFIAVKTTRKFHRARLDLLFETWISRHKEMTFIFTDGEDEALAKHTGNVVLTNCSAAHSRQALSCKMAVEYDRFIESGKKWFCHVDDDNYVNLRALLRLLASYPHTQDVYIGKPSLDRPIQATERISEHRVRPVHFWFATGGAGFCISRGLALKMGPWASGGHFMSTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTTELHEQVTLSYGMFENKRNAVHIKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIL

Gene
lfng
Protein
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Organism
Xenopus laevis
Length
375 amino acids
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning (By similarity). May be involved in mesoderm development (PubMed:8662522).
Similarity
Belongs to the glycosyltransferase 31 family.
Mass
42.134 kDa
Sequence
MLKNWGKKLLLSIVGATLTCLLVLVVDQQSRHMLETQSDHEPGSAAAVHLRADLDPANPGDGGDPANSAQDSGTFSAYFNKLTRVRRDVEQVAAPSKDSAAPEEDITANDVFIAVKTTKKFHRSRMDLLMDTWISRNKEQTFIFTDGEDEELQKKTGNVISTNCSAAHSRQALSCKMAVEYDKFIESDKKWFCHVDDDNYVNVRTLVKLLSRYSHTNDIYIGKPSLDRPIQATERISESNMRPVNFWFATGGAGFCISRGLALKMSPWASGGHFMNTAEKIRLPDDCTIGYIIESVLGVKLIRSNLFHSHLENLHQVPQSEIHNQVTLSYGMFENKRNAILMKGAFSVEEDPSRFRSVHCLLYPDTPWCPWKAAY

Gene
lfng
Protein
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Organism
Danio rerio
Length
374 amino acids
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain (PubMed:11429294, PubMed:14518000).
Similarity
Belongs to the glycosyltransferase 31 family.
Mass
41.882 kDa
Sequence
MLKTYRGKVVVSLAGATVTCLGFLLFLSQHQRIQADGMQNESEVGLRSLQSLGDSETDDGAQPEQNAKKGFSAYFSKLTRSRREADKPSEAPGAATDAPPAEDISADDIFIAVKTTKKFHRSRLDLLLDTWISRNMRQTYIFTDGEDEELKKKIGSHAINTNCSAAHSRQALSCKMAVEYDKFIESGKKWFCHVDDDNYVNTKTLVKLLSNYPHTQDMYIGKPSLDRPIEATERLGDNKMRPVNFWFATGGAGFCISRGLALKMSPWASGGHFMNTAEKIRLPDDCTIGYIIESVLGVSLTRSSLFHSHLENLQQVSKSEVHKQITLSYGMFENKRNIINMKGAFSVEEDPSRFKSVHCLLYPDTPWCPPQVAY

Gene
LFNG
Protein
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Organism
Gallus gallus
Length
363 amino acids
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning.
Similarity
Belongs to the glycosyltransferase 31 family.
Mass
40.658 kDa
Sequence
MLKSCGRKLLLSLVGSMFTCLLVLMVEPPGRPGLARGEAGGAQRALQSLGAARAAGQGAPGLRSFADYFGRLSRARRELPAAPPSPPRPPAEDITPRDVFIAVKTTKKFHKARLELLLDTWISRNRDMTFIFTDGEDEELKKQARNVINTNCSAAHSRQALSCKMAVEYDKFIESGRKWFCHVDDDNYVNVRTLVKLLSSYPHTQDIYIGKPSLDRPIQATERISENKMHPVHFWFATGGAGFCISRGLALKMSPWASGGHFMSTAEKIRLPDDCTIGYIIESVLGVKLIRSNLFHSHLENLHQVPKTEIHKQVTLSYGMFENKRNSIHMKGAFSVEEDPSRFRSVHCLLYPDTPWCPSNVVY