LanA

Laminin subunit alpha

3712 amino acids

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth.

411.157 kDa

MGHGVASIGALLVILAISYCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPPENAIDGTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVPLENGEIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQCICREGFGGPRCDQCLPGFYNYPDCKPCNCSSTGSSAITCDNTGKCNCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYNFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICDCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFVLLPAAYYEAGILTRHISNPCELGNMELCRHYKYASVEVFSPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHYIVDVPRSGRYIFVIDYISDRNFPDSYYINLKLKDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQPVIISADIEDGSRFPIISVTAIPVDQWSIDYINPSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPTTGECMCPPNVIGDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNFPHCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTTCFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKFDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSDVYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRDPSGPYGGYCIPCECNGHSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPCECSGNINPEDQGSCDTRTGECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGTQTCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGVGCRACDCGAASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRGFGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKDEGCQECNNCHHALLDVTDRMRYQIDSVLEDFNSVTLAFFTSQKLNYYDQLADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLEDLFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLRDALNELNSFNKNVDEELPVREDQHKEADALTDQAEQKAAELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLADTGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEHQLKDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLNELAEDIEEQQHRVGSQSRQLGQEIENLKAQVEAARQLANSIKVGVNFKPSTILELKTPEKTKLLATRTNLSTYFRTTEPSGFLLYLGNDNKTAQKNNDFVAVEIVNGYPILTIDLGNGPERITSDKYVADGRWYQAVVDRMGPNAKLTIREELPNGDVVEHSKSGYLEGSQNILHVDKNSRLFVGGYPGISDFNAPPDLTTNSFSGDIEDLKIGDESVGLWNFVYGDDNDQGARERDVLLEKKKPVTGLRFKGNGYVQLNATSNLKSRSSIQFSFKADKDTSNGLLFFYGRDKHYMSIEMIDGAIFFNISLGEGGGVQSGSQDRYNDNQWHKVQAERENRNGLLKVDDIVISRTNAPLEADLELPKLRRLYFGGHPRRLNTSISLQPNFDGCIDNVVINQGVVDLTEYVTGGGVEEGCSAKFSTVVSYAPHEYGFLRMNNVSSDNNLHVVLHFKTTQPNGVLFYAANHDQSSTIGLSLQDGLLKLNSMGSQLVIDDRILNDGEDHVVTVQHTQGELRLTVDDVDNKRLGSPQPLILEGGDIFFAGLPDNYRTPRNALASLAYFVGCISDVTVNEEIINFANSAEKKNGNINGCPPHVLAYEPSLVPSYYPSGDNEVESPWSNADTLPPLKPDIESTLPPTTPTTTTTTTTTTTSTTTTSTTTTTTTPSPIVIDEEKEIEAKTPQKILTTRPPAKLNLPSDERCKLPEQPNFDVDFTEAGYRFYGLREQRLQINSLPVKVRRHHDIGISFRTERPNGLLIYAGSKQRDDFIAVYLLDGRVTYEIRVGAQLQAKITTEAELNDGTWHTVEVVRTQRKVSLLIDKLEQPGSVDLNAERSAPVLAVELPIYLGGVNKFLESEVKNLTDFKTEVPYFNGCLKNIKFDAMDLETPPEEFGVVPCSEQVERGLFFNNQKAFVKIFDHFDVGTEMKISFDFRPRDPNGLLFSVHGKNSYAILELVDNTLYFTVKTDLKNIVSTNYKLPNNESFCDGKTRNVQAIKSKFVINIAVDFISSNPGVGNEGSVITRTNRPLFLGGHVAFQRAPGIKTKKSFKGCISKVEVNQRMINITPNMVVGDIWQGYCPLN

lanA

Lantibiotic mutacin-1140

63 amino acids

Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Belongs to the type A lantibiotic family.

6.968 kDa

MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTRFKSWSLCTPGCARTGSFNSYCC