About Products Protein Database Contact

Lamtor2

Gene
Lamtor2
Protein
Ragulator complex protein LAMTOR2
Organism
Mus musculus
Length
125 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Similarity
Belongs to the GAMAD family.
Mass
13.48 kDa
Sequence
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS

Gene
lamtor2
Protein
Ragulator complex protein LAMTOR2
Organism
Salmo salar
Length
125 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the GAMAD family.
Mass
13.549 kDa
Sequence
MLRPKALTQVLSQANTSGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWSAYDKNGHQAFNEDKLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAEALVLYLEEPLTQVAAS

Gene
LAMTOR2
Protein
Ragulator complex protein LAMTOR2
Organism
Taeniopygia guttata
Length
125 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the GAMAD family.
Mass
13.531 kDa
Sequence
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWVAYDKNGHQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS

Gene
lamtor2
Protein
Ragulator complex protein LAMTOR2
Organism
Xenopus tropicalis
Length
125 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the GAMAD family.
Mass
13.589 kDa
Sequence
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDKNGHQAFNEDNLKFILMDCMEGRVAITRVSNLLLCMYAKETVGFGMLKAKAQALVYYLEESLNQVSSS

Gene
LAMTOR2
Protein
Ragulator complex protein LAMTOR2
Organism
Bos taurus
Length
125 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity).
Similarity
Belongs to the GAMAD family.
Mass
13.508 kDa
Sequence
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS

Gene
lamtor2
Protein
Ragulator complex protein LAMTOR2
Organism
Danio rerio
Length
125 amino acids
Function
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).
Similarity
Belongs to the GAMAD family.
Mass
13.578 kDa
Sequence
MLRPKALTQVLSQANTSGVQSTLLLNNEGSLLTYSGYGDTDARVTAAIASNIWAAYDKNGHQAFNEDKLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAEALVQYLEEPLTQVAAS

Gene
LAMTOR2
Protein
Ragulator complex protein LAMTOR2
Organism
Homo sapiens
Length
125 amino acids
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Similarity
Belongs to the GAMAD family.
Mass
13.508 kDa
Sequence
MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAFNEDNLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS