Protein
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Function
Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.
Similarity
Belongs to the AlaDH/PNT family.
Sequence
MTAPVKLHLRAETKPLEHRSALTPTTTRKLLDAGFEVFVEKSPLRIFDDQEFVDVGATLVEEGSWVSAPEDRMIIGLKELPEESFPLSHEHIQFAHCYKDQGGWKDVLSRFPAGNGTLYDLEFLEDDNGRRVAAFGFHAGFAGAAIGVETWAFQQTHPDSENLPGVSAYPNETELVDKIKKDLAAAVEKGSKLPTVLVIGALGRCGSGAIDLARKVGIPEENIIRWDMNETKKGGPFQEIADADIFINCIYLSQPIPPFINYDLLNKETRKLSVIVDVSADTTNPHNPVPVYTIATTFDHPTVPVETTAGPKLSVCSIDHLPSLLPREASEAFSEALLPSLLQLPQRDTAPVWTRAKALFDKHVLRIGE