lys1

L-2-aminoadipate reductase

1419 amino acids

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

Belongs to the ATP-dependent AMP-binding enzyme family.

156.894 kDa

MSQTAPSDTEYNQRLERWSERLKSQTISHLPTDYSRPVPSRLVEAVFERTLPEDAKTALIKVYVAAQAKGILVTPFNILLTIFIILVSRMTGDEDISIGTSSENAIPFVLRTFIQPSDSFLDLLAKVCDLEKEGSSDAVDFSDLINFLNAKLSKKDDPRKTLVHLRFYNAPDAPSENFLSTTGLDVDLTVLVSVKKPSDQLTSLRSQFTFPDLQLKLIYNQLLFSESRVNIVADQLLKLVVSASKDVTGPIGALDLMTPTQMNVLPDPTVDLDWSGYRGAIQDIFASNAAKFPDRECIVVTPSVTIDAPVTSYTYRQIDESSNILAHHLVKNGIERGDVVMVYAYRGVDLVVAVMGVLKAGATFSVIDPAYPPARQIIYLSVAKPRALVVLEDAGVLSPTVVEYVEKSLELKTYVPALKLAKDGSLTGGSVSKGADDILQHVLHLKSEQTGVVVGPDSTPTLSFTSGSEGIPKGVKGRHFSLAYYFDWMAQEFNLSESDRFTMLSGIAHDPIQRDIFTPLFLGASLIVPTAEDIGTPGQLAQWANKYKVTVTHLTPAMGQLLAAQADEPIPSLHHAFFVGDILTKRDCLRLQVLANNVNVVNMYGTTETQRSVSYFVVPARSQDQTFLESQKDVIPAGRGMKNVQLLVINRFDTNKICGIGEVGEIYLRAGGLAEGYLGNDELTSKKFLKSWFADPSKFVDRTPENAPWKPYWFGIRDRMYRSGDLGRYLPTGNVECSGRADDQIKIRGFRIELGEINTHLSRHPNVRENITLVRRDKDEEPTLVAYIVPQGLNKDDFDSATESEDIVVNGLKKYRKLIHDIREYLKTKLPSYAIPSVIVPLHKMPLNPNGKIDKPALPFPDTSQLAAASRSHSKHGVDETLTATERDIRDIWLRIIPHATDVNKKASFFDIGGHSILATRLIFELRKKFAVNVPLGLVFSEPTIEGLAKEIERMKSGEMISVMDIGKEETREPEIEYGKDALDLVDLIPKEFPTSKDLGIDEPKTVFLTGANGYLGVFILRDLMTRSSNLKVIALVRASSEEHGLKRLKDSCTAYGVWDESWAQKISVVNGDLALENWGIEERKWNKLTEVVDYVIHNGALVHWVYPYSKLRGPNVMGTITALKLCSLGKGKSLSFVSSTSTVDTEYYVNLSNEITSKGGNGIPESDPLQGSSKDLHTGYGQSKWVSEYLVRQAGLRGLRGVVVRPGYILGDSKSGAINTDDFLVRMVKGCIELGLYPNINNTVNMVPADHVARVVTASAFHPEQGVIVAHVTSHPRLRFNQFLGTLSTFGFNTKLSEYVNWRIALERFVINESHDSALYPLLHFVLDNLPANTKAPELDDTNTREILKRDASWTNVDVSNGAAILEHEMGLYLSYLVAIGFLPKPTLEGKKLPEVKINEATLEKLASAGGRGGAPTH

lys1

Homocitrate synthase, mitochondrial

474 amino acids

Belongs to the alpha-IPM synthase/homocitrate synthase family.

51.985 kDa

MVLLPPSLPVCQLKVTAPEFPSNFYLDGDHSGFVGIETRQNPHPSASRNPYGHDAGVTDFLSNVSRFQIIESTLREGEQFANAFFDTAKKIEIAKALDDFGVDYIELTSPCASEQSRADCEAICKLGLKAKILTHIRCHMDDARIAVETGVDGVDVVIGTSSYLREHSHGKDMTYIKNAAIEVIEFVKSKGIEIRFSSEDSFRSDLVDLLSIYSAVDKVGVNRVGIADTVGCASPRQVYELVRVLRGVVGCDIETHFHNDTGCAIANAFCALEAGATHIDTSVLGIGERNGITPLGGLMARMMVADREYVKSKYKLEKLKEIEDLVAEAVEVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEIINPADFGMSRYVHFASRLTGWNAIKSRAQQLKLEMTDTQYKECTAKIKAMADIRPIAVDDADSIIRAYHRNLKSGENKPLLDLTAEEQAAFAAKEKELLEAQAAGLPV

LYS1

Homocitrate synthase, mitochondrial

446 amino acids

Belongs to the alpha-IPM synthase/homocitrate synthase family.

48.437 kDa

MCATDNAPAANAAPEKPSNVGVEVGHTGEQTNPYGANPADFLSNVSKFQLIESTLREGEQFASAFFDTETKIEIAKALDDFGVDYIELTSPAASEQSRSDCEAICKLGLKAKILTHIRCHMDDARLAVSTGVDGVDVVIGTSQFLRQYSHGKDMNYIAQSAVEVIEFVKSHGIEIRFSSEDSFRSDLVDLLNIYRTVDKIGVNRVGIADTVGCANPRQVYELVRTLKSVVSCDIECHFHNDTGCAIANAYTALEAGANLIDVSVLGIGERNGITSLGGLMARMIAADRDYVLSKYKLHKLRDLENLVADAVQVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILNPADFGLTRYIHFANRLTGWNAIKSRVDQLNLHLTDAQCKDVTAKIKKLGDVRSLNIDDVDSIIREFHADVTSTPTVAATEGPAVEDEPAAKKAKTEE

LYS1

Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

382 amino acids

Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.

Belongs to the AlaDH/PNT family.

42.394 kDa

MSKSPVILHLRAETKPLEARAALTPSTTKQLLDAGFEIYVEESSQSTFDIKEYEAVGAKIVPEGSWKTAPKERIIFGLKELPENETFPLIHEHIQFAHCYKDQAGWQDVLKRFPQGNGILYDLEFLENDQGRRVAAFGFYAGFAGAAIGVLDWSFKQLNGNTKGTKGEGEGGELPGVTPYPNENELIKDVKIELEKALTKNGGQYPKCLVIGALGRCGSGAIDLFKKIGIPDDNIAKWDMAETAKGGPFQEIVDSDIFINCIYLSKPIPPFINKEILNNENRKLTTIVDVSADTTNPHNPIPVYEIATVFNEPTVEVKLDKGPKLSVCSIDHLPSLLPREASEFFAKDLMPSLLELPNRDTSPVWVRAKQLFDKHVARLDKE

LYS1

Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

373 amino acids

Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.

Belongs to the AlaDH/PNT family.

41.465 kDa

MAAVTLHLRAETKPLEARAALTPTTVKKLIAKGFKIYVEDSPQSTFNINEYRQAGAIIVPAGSWKTAPRDRIIIGLKEMPETDTFPLVHEHIQFAHCYKDQAGWQNVLMRFIKGHGTLYDLEFLENDQGRRVAAFGFYAGFAGAALGVRDWAFKQTHSDDEDLPAVSPYPNEKALVKDVTKDYKEALATGARKPTVLIIGALGRCGSGAIDLLHKVGIPDANILKWDIKETSRGGPFDEIPQADIFINCIYLSKPIAPFTNMEKLNNPNRRLRTVVDVSADTTNPHNPIPIYTVATVFNKPTVLVPTTAGPKLSVISIDHLPSLLPREASEFFSHDLLPSLELLPQRKTAPVWVRAKKLFDRHCARVKRSSRL

LYS1

Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

372 amino acids

Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.

Belongs to the AlaDH/PNT family.

40.974 kDa

MSAILHLRAETKPMEARAALTPTTVRTLVSHGFKIYVEESAQSVFEAAEYAAAGAEVVATGSWRGAPRERIIVGLKELPEEDTFPLEHTHIQFAHCYKNQSGWREVLGRFQSGGGLLYDLEFLQDDRGRRVAAFGYYAGFAGAALGLRDWAWKQTHTDAEDLPAVAPYENEQALVSEVAAACEEAYKKGARKPRVLVIGALGRCGSGAVELLRQCGLHDKHIIRWDIAETARGGPFPEIAAADIFINCIYLSQPIAPFINMELLDRPDRKLRTIVDVSADTTNPHNPVPVYNVATVFSSPTVVVPTSQGPKLSVISIDHLPSLLPREASEAFASDLLPSLLQLPERDTAPVWLRAKELFQQHCERLSKEARL

LYS1

Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

372 amino acids

Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.

Belongs to the AlaDH/PNT family.

41.552 kDa

MSVTLHLRGETKPLEHRAALTPTTVKHLIGKGFKIYVEESPQSIFKIDEYRRAGAIIVPFGSWISAPRDRIIIGLKEMPEEDKFPLVHEHIQFAHCYKDQAGWKDVLRRFINGNGTLYDLEFLEDDNGRRVAAFGFYAGFAGAALGLADWAFKQTHKDSEDLPAVSPYPNEKALIKDIGKAYKNALKTGAKKPKVLIIGALGRCGSGAIDFLKKVGLPEENIIKWDIQETSRGGPFPEIAASDIFINCIYLSKPIAPFINYELLNKPDRKLRTVVDVSADTTNPHNPIPIYNIATVFNKPTVKVNTSSGPKLSVISIDHLPSLLPREASEFFAHDLLPSLEQLPSRHVSPVWVRAEKLFNRHSARAIRESKL