LTA4H

Gene

LTA4H

Protein

Leukotriene A-4 hydrolase

Organism

Bos taurus

Length

611 amino acids

Function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity (By similarity).

Similarity

Belongs to the peptidase M1 family.

Mass

69.306 kDa

Sequence

MPEVVDTCSLASPASVCQTKHLHLRCSIDFTRRVLSGTAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYTLGERQSYKGSPIEISLPIALCKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYSAEVSVPKELVALMSAIRDGEAPDPEDPNRKIYRFSQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYIWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNSIKTFGETHPFTKLVVDLTNTDPDVAYSSVPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYKSITTDNWKDFLYSHFKDKVDILNQVDWNTWLYSPGLPPVKPNYDMTLTNACISLSQRWITAKDDDLNSFSSADLKDFSSHQVNEFLAQMLQNAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIRTYKEHKASMHPVTAMLVGKDLKVD

Protein

Leukotriene A-4 hydrolase: LTA4H

Gene

LTA4H

Protein

Leukotriene A-4 hydrolase

Organism

Cavia porcellus

Length

611 amino acids

Function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

Similarity

Belongs to the peptidase M1 family.

Mass

68.971 kDa

Sequence

MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETESMLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGETQAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVTAMLVGKDLKVE

Protein

Leukotriene A-4 hydrolase: LTA4H

Gene

LTA4H

Protein

Leukotriene A-4 hydrolase

Organism

Chinchilla lanigera

Length

611 amino acids

Function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity (By similarity).

Similarity

Belongs to the peptidase M1 family.

Mass

69.213 kDa

Sequence

MPEVEDTCFLTSPITVCRTKHLHLRCSVDFSSRALTGIAALTIQSQEDNLRSLVLDTKALTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAVLPCQDTPSVKLTYTAEVSVPKELVALMSAVRDGETPDPEDPSRKIYKFNQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGETHPFTKLVVDLTDVDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVERFSYKSITTDDWKNFLYSHFKDKVDILNQVDWNAWLYSPGLPPVKPNYDMTLTNACIALSQRWITAKEEDLNTFNATDLKDLSTHQVNEFLAQVLQQAPLPLGHVKRMQEVYNFNAVNNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIRTYQAHKASMHPVTAMLVGKDLKVD

Protein

Leukotriene A-4 hydrolase: LTA4H

Gene

LTA4H

Protein

Leukotriene A-4 hydrolase

Organism

Homo sapiens

Length

611 amino acids

Function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

Similarity

Belongs to the peptidase M1 family.

Mass

69.285 kDa

Sequence

MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD

Protein

Leukotriene A-4 hydrolase: LTA4H

Gene

Lta4h

Protein

Leukotriene A-4 hydrolase

Organism

Mus musculus

Length

611 amino acids

Function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

Similarity

Belongs to the peptidase M1 family.

Mass

69.051 kDa

Sequence

MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVTAMLVGRDLKVD

Protein

Leukotriene A-4 hydrolase: Lta4h

Gene

Lta4h

Protein

Leukotriene A-4 hydrolase

Organism

Rattus norvegicus

Length

610 amino acids

Function

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

Similarity

Belongs to the peptidase M1 family.

Mass

69.176 kDa

Sequence

MPEVEDTCSLASPASVCRTQHLHLRCSVDFARRALTGTAALTVQSQEDNLRTLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQWEAIHCRAILPCQDTSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYQSVTTDDWKSFLYAHFKDKVDLLNQVDWNAWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLNSFSIEDLKDLSSHQLNEFLAQVLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKACMHPVTAMLVGKDLKVD

Protein

Leukotriene A-4 hydrolase: Lta4h