lrrc8e

Volume-regulated anion channel subunit LRRC8E

806 amino acids

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depend on the precise subunit composition.

Belongs to the LRRC8 family.

92.244 kDa

MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYITYAMLMIGVFGCTLQVTQDKIICLPNHTSADVVSQITCQEFTQQSSASNDSDLETTVPPPTATSSPPREMSGLRNNLDLQQYSFINQMCYETALHWYAKYFPYLVVIHTLIFIICGNFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGESSQEKPNQERSIDRELSKPNFEEGSPATADLPIPDKLVAETSSASALDKKEGEQAKALFEKVKKFRHHVEEGDLLYSMYMRQTVLKVCKFVLITIYNAVLVGKIHFIVPCSVHTEDMTGYNSFCCNHTKAHLFSKLAISYLCFLGVYGLTCFYTLYWLFRRPLKEYSFRSVREETGIGDIPDVKNDFAFVLHLVDQYDSLYSKRFAVFLSEVSESRLRQLNLNHEWPADKLRQKLQHTPEGRLELHLFKLPGLPDTVFEVAEMESLKLEMVNEALIPPLVSKLVRLEELSLLNCTAKVQHASMAYLRDHLRILQVKFDDIKEIPLWIFGLRALEELHLFGWLSQDLSKNPALESLRELKSLKVLTIKSNLSKIPATVADVAGHLQKFSIHNDGTKLLTLNALKRLVLVKELELVRCELERIPHAVFSLTNLQVLDLKENTLHTIEEIISLQHCRKLSVLRLWHNQIAYIPDHIRKLKGLEELSLNRNKILVIPSQLFLCNKLRHLDLSFNEIRELPPEIGVLQLLQYLGLSGNFLEDLPTELFFCQKLKTLKLGQNRLASLSPKVGSLVCLVKLELKGNRMDMLPPEIGNCLSLKRSGLNVESLLFDTLPVDVRDKFKED

lrrc8e

Volume-regulated anion channel subunit LRRC8E

806 amino acids

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depend on the precise subunit composition.

Belongs to the LRRC8 family.

92.205 kDa

MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYITYAMLMIGVFGCTLQVTQDKIICLPNHTSADVVSQITCQEYDQQSPPSNDSDLETTIPPPTATSSPPREMSGLRNNLDLQQYSFINQMCYETALHWYAKYFPYLVVIHTLIFIICGNFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGESSQEKPSQERSIDRELSKPNFEEGSPATADLPIAEKLVAETSSASVLDKKEGEQAKALFEKVKKFRHHVEEGDLLYSMYMRQTVLKVCKFVLITIYNAVLVGKIHFIVPCSVHTEDMTGYNSFCCNHTKAHLFSKLAITYLCFLGVYGLTCLYTLYWLFRRPLKEYSFRSVREETGIGDIPDVKNDFAFVLHLVDQYDSLYSKRFAVFLSEVSESRLRQLNLNHEWPADKLRQKLQHTPEGRLELHLFKLPGLPDTVFEVAEMESLKLEMVNEALIPPLVSKLVRLEELSLINCTAKVQHASLAYLRDHLRILQVKFDDIKEIPLWIFSLRALEELHLFGWLSQDLSKNPALESLRELKSLKVLTIKSNLSKIPATVADVAGHLQKFSIHNDGTKLLTLNALKRLALVKELELVRCELERIPHAVFSLTNLQVLDLKENTLHTIEEIISLQHCRKLSVLRLWHNQIAYIPEHIRKLKGLEELSLNRNKILVIPSQLFLCNKLRHLDLSNNEIRELPPEIGVLQLLQYLGLSGNFLEDLPNELFFCQKLKTLKLGQNRLGNLSPKVGSLVCLVKLELKGNRMDTLPPELGNCVSLKRSGLTVEPSLFETLPVEVRDKLKED

LRRC8E

Volume-regulated anion channel subunit LRRC8E

796 amino acids

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).

Belongs to the LRRC8 family.

90.247 kDa

MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPNHELQENLSEAPCQQLLPRGIPEQIGALQEVKGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEVRDKMEEE

Lrrc8e

Volume-regulated anion channel subunit LRRC8E

795 amino acids

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.

Belongs to the LRRC8 family.

90.501 kDa

MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENISGAPCQQLLPQGISEQMGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENHKGPASGRAMVTTVTTTGAGSGKVGEGEKEKVLIEPEKVVSEPPVVTLLDKKEGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLIYVEKISFLVACRVETSEITGYASFCCNHTKAHLFSKLAFCYISFVCVYGITCLYTLYWLFHRPLKEYSFRSVREETGMNDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNMRGRLELSLCMLPGLPDTVFELSEVEALRLEAICDISFPPGLSQLVNLQELSLLHSPARLPFSSQIFLRDRLKVICVKFEELREVPLWVFGLRGLEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETLPTQLGQCFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQLSPDVAALQALSRLELKGNRLETLPEELGDCKGLKKSGLLVEDTLYEGLPAEVREKMEEE

Lrrc8e

Volume-regulated anion channel subunit LRRC8E

795 amino acids

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202).

Belongs to the LRRC8 family.

90.445 kDa

MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLPSHESRENSSEAPCQQLLPQGISEQIGGLRELSGLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENHKGPAAGRATVTTVTTVGTGTGKVGEGEKEKVLIEPEKVVTEPPAVTLLDKKEGEQAKALFEKVKKFRVHVEEGDILYSMYIRQTVLKVCKFFAILVYNLVYVEKISFLVACRVETSEITGYASFCCNHTKAHLFSKLAFCYISFVCVYGITCLYTLYWLFHRPLKEYSFRSVREETGMNDIPDVRNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPDKLRQKLQRNARGRLELSLCMLPGLPDTVFELSEVEALRLEAICDISFPPGLSQLVNLQELSLLHSPARLPFSSQIFLRDRLKVICVKFEELREVPLWVFGLRGLEELHLEGLFPPEMARGATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLERIPHAIFSLGALQELDLKDNHLRSIEEILSFQHCRKLVILRLWHNQIAYVPEHVRKLRSLEQLYLSHNKLETLPAQLGQCFGLRLLDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFFCHKLRTLLLGYNHLTQFSPHVAALQALSRLELKGNRLEALPEELGDCKGLKKSGLLVEDTLYEGLPAEVREKMEEE