LPS

Bifunctional levopimaradiene synthase, chloroplastic

873 amino acids

Catalyzes the initial cyclization step in the biosynthesis of ginkgolides, a structurally unique family of diterpenoids that are highly specific platelet-activating-factor receptor antagonists. Bifunctional enzyme that catalyzes two sequential cyclizations of geranylgeranyl diphosphate (GGPP) to levopimaradiene.

Belongs to the terpene synthase family. Tpsd subfamily.

100.29 kDa

MAGVLFANLPCSLQLSPKVPFRQSTNILIPFHKRSSFGFNAQHCVRSHLRLRWNCVGIHASAAETRPDQLPQEERFVSRLNADYHPAVWKDDFIDSLTSPNSHATSKSSVDETINKRIQTLVKEIQCMFQSMGDGETNPSAYDTAWVARIPSIDGSGAPQFPQTLQWILNNQLPDGSWGEECIFLAYDRVLNTLACLLTLKIWNKGDIQVQKGVEFVRKHMEEMKDEADNHRPSGFEVVFPAMLDEAKSLGLDLPYHLPFISQIHQKRQKKLQKIPLNVLHNHQTALLYSLEGLQDVVDWQEITNLQSRDGSFLSSPASTACVFMHTQNKRCLHFLNFVLSKFGDYVPCHYPLDLFERLWAVDTVERLGIDRYFKKEIKESLDYVYRYWDAERGVGWARCNPIPDVDDTAMGLRILRLHGYNVSSDVLENFRDEKGDFFCFAGQTQIGVTDNLNLYRCSQVCFPGEKIMEEAKTFTTNHLQNALAKNNAFDKWAVKKDLPGEVEYAIKYPWHRSMPRLEARSYIEQFGSNDVWLGKTVYKMLYVSNEKYLELAKLDFNMVQALHQKETQHIVSWWRESGFNDLTFTRQRPVEMYFSVAVSMFEPEFAACRIAYAKTSCLAVILDDLYDTHGSLDDLKLFSEAVRRWDISVLDSVRDNQLKVCFLGLYNTVNGFGKDGLKEQGRDVLGYLRKVWEGLLASYTKEAEWSAAKYVPTFNEYVENAKVSIALATVVLNSIFFTGELLPDYILQQVDLRSKFLHLVSLTGRLINDTKTYQAERNRGELVSSVQCYMRENPECTEEEALSHVYGIIDNALKELNWELANPASNAPLCVRRLLFNTARVMQLFYMYRDGFGISDKEMKDHVSRTLFDPVA

LPS

Bifunctional levopimaradiene synthase, chloroplastic

850 amino acids

Involved in defensive oleoresin formation in conifers in response to insect attack or other injury. Involved in diterpene (C20) olefins biosynthesis. Bifunctional enzyme that catalyzes two sequential cyclizations of geranylgeranyl diphosphate (GGPP) to levopimaradiene. Levopimaradiene is the major products of the enzyme followed by abietadiene, neoabietadiene and palustradiene. No activity with geranyl diphosphate (GPP) or farnesyl diphosphate (FPP) as substrate.

Belongs to the terpene synthase family. Tpsd subfamily.

97.499 kDa

MALPSSSLSSQIHTGATTQCIPHFHGSLNAGTSAGKRRSLYLRWGKGPSKIVACAGQDPFSVPTLVKREFPPGFWKDHVIESLMPSYKVAPSDEKRIETLITEIKNMFRSMGYGETNPSAYDTAWVARIPAVDGSEKPQFPETLEWILQNQLKDGSWGEEFYFLAYDRILATLACIITLTIWQTGDTQVQKGIEFFKTQAGKIEEEADSHRPSGFEIVFPAMLKEAKALGLALPYELPFIQQIIEKREAKLQRLPPDLLYALPTTLLYSLEGLQEIVDWEKIMKLQSKDGSFLSSPASTAAVFMRTGNKKCLEFLNFVLKKFGNHVPCHYPLDLFERLWAVDTVERLGIDHHFKEEIKDALDYVYSHWDERGIGWARENPVPDIDDTAMGLRILRLHGYNVSSDVLKTFRDENGEFFCFLGQTQRGVTDMLNVNRCSHVAFPGETIMEEAKLCTERYLRNALEDGGASDKWALKKNIRGEVEYALKYPWHRSMPRLEARSYIENYGPNDVWLGKTMYMMPNISNEKYLELAKLDFNRVQFFHRQELQDIRRWWNSSGFSQLGFTRERVAEIYFSPASFLFEPEFATCRAVYTKTSNFTVILDDLYDAHGTLDNLKLFSESVKRWDLSLVDQMPQDMKICFKGFYNTFNEIAEEGRKRQGRDVLSYIQKVWEVQLEAYTKEAEWSAVRYVPSYDEYIGNASVSIALGTVVLISALFTGEILTDDILSKIGRDSRFLYLMGLTGRLVNDTKTYQAERGQGEVASAVQCYMKDHPEISEEEALKHVYTIMDNALDELNREFVNNRDVPDTCRRLVFETARIMQLFYMDGDGLTLSHNMEIKEHVKNCLFQPVA