LON1

Lon protease homolog 1, mitochondrial

940 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Belongs to the peptidase S16 family.

103.93 kDa

MLKLFTSSASRVHHLTPVSRVVGSSPVESPLFKALSQITGWNRRSTSLGHRAFFCSEPTNGEAAAEAETKAVESDSEVSDSKSSSAIVPTNPRPEDCLTVLALPVPHRPLFPGFYMPIYVKDPKVLAALQESRRRQAPYAGAFLLKDDPSADSSSSTDAEKNINELKGKELLNRLHEVGTLAQISSIQGDQVILVGHRRLRIKEMVSEEPLTVKVDHLKDNPFDMDDDVVKATSFEVISTLRDVLKTSSLWRDHVQTYTQHIGDFTYPRLADFGAAICGANRHQAQEVLEELDVHKRLRLTLELMKKEMEISKIQETIAKAIEEKISGEQRRYLLNEQLKAIKKELGVETDDKSALSAKFKERIEPNKEKIPAHVLQVIEEELTKLQLLEASSSEFNVTRNYLDWLTILPWGNYSNENFDVARAQTILDEDHYGLSDVKERILEFIAVGRLRGTSQGKIICLSGPPGVGKTSIGRSIARALNRKFFRFSVGGLADVAEIKGHRRTYVGAMPGKMVQCLKSVGTANPLVLIDEIDKLGRGHAGDPASALLELLDPEQNANFLDHYLDVTIDLSKVLFVCTANVIDMIPNPLLDRMEVISIAGYITDEKVHIARDYLEKTARGDCGVKPEQVEVSDAALLSLIENYCREAGVRNLQKQIEKIYRKIALKLVREGAVPEEPAVASDPEEAEIVADVGESIENHTVEENTVSSAEEPKEEAQTEKIAIETVMIDESNLADYVGKPVFHAEKLYEQTPVGVVMGLAWTSMGGSTLYIETTVVEEGEGKGGLNITGQLGDVMKESAQIAHTVARKIMLEKEPENQFFANSKLHLHVPAGATPKDGPSAGCTMITSLLSLATKKPVRKDLAMTGEVTLTGRILPIGGVKEKTIAARRSQIKTIIFPEANRRDFDELAENVKEGLNVHFVDDYGKIFELAFGYDKQED

LON1

Lon protease homolog 2, peroxisomal

885 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.

Belongs to the peptidase S16 family.

97.733 kDa

MSDSPVELPSRLAVLPFRNKVLLPGAIVRIRCTNPSSVKLVEQELWQKEEKGLIGVLPVRDSEATAVGSLLSPGVGSDSGEGGSKVGGSAVESSKQDTKNGKEPIHWHSKGVAARALHLSRGVEKPSGRVTYIVVLEGLCRFSVQELSARGPYHVARVSRLDMTKTELEQAEQDPDLIALSRQFKATAMELISVLEQKQKTVGRTKVLLDTVPVYRLADIFVASFEISFEEQLSMLDSVHLKVRLSKATELVDRHLQSILVAEKITQKVEGQLSKSQKEFLLRQQMRAIKEELGDNDDDEDDVAALERKMQNAGMPANIWKHAQREMRRLRKMQPQQPGYSSSRAYLELLADLPWQKVSEERELDLRVAKESLDQDHYGLTKVKQRIIEYLAVRKLKPDARGPVLCFVGPPGVGKTSLASSIAKALNRKFIRISLGGVKDEADIRGHRRTYIGSMPGRLIDGLKRVSVSNPVMLLDEIDKTGSDVRGDPASALLEVLDPEQNKAFNDHYLNVPFDLSKVIFVATANRMQPIPPPLLDRMEIIELPGYTPEEKLKIAMKHLIPRVLEQHGLSTTNLQIPEAMVKLVIERYTREAGVRNLERNLAALARAAAVKVAEQVKTLRLGKEIQPITTTLLDSRLADGGEVEMEVIPMEHDISNTYENPSPMIVDEAMLEKVLGPPRFDDREAADRVASPGVSVGLVWTSVGGEVQFVEATAMVGKGDLHLTGQLGDVIKESAQLALTWVRARAADLNLSPTSDINLLESRDIHIHFPAGAVPKDGPSAGVTLVTALVSLFSNRKVRADTAMTGEMTLRGLVLPVGGVKDKVLAAHRYGIKRVILPERNLKDLSEVPLPILSDMEILLVKRIEEVLDHAFEGRCPLRSRSKL

LON1

Lon protease homolog 2, peroxisomal

884 amino acids

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.

Belongs to the peptidase S16 family.

97.336 kDa

MADAAVELPGRLAILPFRNKVLLPGAIVRIRCTNPSSVKLVEQELWQREEKGLIGVLPVHDSEAAGSLLSPGVGSDSGEGGSKAPGGSAGESTKQDTKNGKETIHWHSRGVAARALHLSRGVEKPSGRVTYIVVLEGLCRFSVQELSARGSYHVARVSRLDMTKTELEHAEQDPDLIALSRQFKATAMELISVLEQKQKTVGRTKVLLETVPVYRLADIFVASFEISFEEQLSMLDSVDLKVRLSKATELVDRHLQSILVAEKITQKVEGQLSKSQKEFLLRQQMRAIKEELGDNDDDEDDVAALERKMQNAGMPANIWKHAQRELRRLRKMQPQQPGYSSSRTYLELLAELPWQKVSEERELDLRAAKESLDRDHYGLTKVKQRIIEYLAVRKLKPDARGPVLCFVGPPGVGKTSLASSIAKALNRKFIRISLGGVKDEADIRGHRRTYIGSMPGRLIDGLKRVSVSNPVMLLDEIDKTGSDVRGDPASALLEVLDPEQNKTFNDHYLNVPFDLSKVIFVATANRMQPIPPPLLDRMEVIELPGYTPEEKLKIAMKHLIPRVLEQHGLSSTYLQIPEAMVRLIIERYTREAGVRNLERNLAALARAAAVKVAEQDSVLRLGKEIQPITTTLLDSRLADGGEVEMEVIPMGQDISNTYENPSPMIVDEAMLEKVLGPPRFDDSEAADRVASPGVSVGLVWTSFGGEVQFVEATAMVGKGDLHLTGQLGDVIKESAQLALTWVRARAADLNLSPTSDINLLESRDIHIHFPAGAVPKDGPSAGVTLVTSLVSLFSHRKVRADTAMTGEMTLRGLVLPVGGVKDKVLAAHRYGIKRVILPERNMKDLAEVPAPILSGLEILLVKRIEEVLDHAFEGGCPLRPHSKL

lon1

Lon protease 1

817 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

91.815 kDa

MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKAVILLAAQKKAKTNDPTPDDIFHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDAFFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRIPPEMLMQVASIDDPARLADTIVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEYYLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEATVVRNYIDWIISLPWYDETQDRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLKGPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDEAEIRGHRRTYIGAMPGKLIQSLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMFICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPALRTIIHRYTRESGVRSLEREIGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGMAEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITGKLGEVMQESAQAAMSYVRSRAERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEITLRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLREALVLEKPEEFGRKPTTDGGKLGGTTELPASPAVAPA

lon1

Lon protease 1

815 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

90.406 kDa

MSEVERTTTIPDEIAILPLLGTVAYPQTIMPLAIGQPESIRLIDDLMAGQRIVGLMALKNEDERPNPVLPEDFYQLGSAAVVHKLMKLPDGTLRAAMQVLERIEIVEIIQTEPYYRAKIRVMPDALAESEQLEVTALMRSIGTIASQIAPLIPQFPTELLNSVLSEEDPRRLAYLVASYARMSVTDRQAVLAEPSIKQKLLKLNEVLTRELNVLQIGQQIQSQVQDEMSKTQREYVLREQLKAIRKELGENNEQEVEVDRLAEQIEAAGMSAEAHQQAMRELDRLRQMPTAAAEYSVIRGYLETLIALPWQKRSDDTIDVAQATEVLDADHYGLDEIKERILDYLAVRELRRKRSPERDPGRGAILCFVGPPGVGKTSLGRSIAKAMNREFVRLSLGGVHDEAEIRGHRRTYIGAMPGSLIQAIRRSGVNNPVVLLDEIDKLSSDHRGDPTSAMLEVLDPAQNTNFRDHYLDVAWDLSPVMFIATANTLQTIPAPLRDRLEIIQLGSYTMREKYEIASRYLVPEQREQHSLAPNEVEIDHEALLVAIEEYTREAGVRNLEQQIGTLMRKAARQVALGSATPIVLDPAKTREYLGKRRYFSEIHERTDRPGIVTGLVWTPVGGDIIFIEATKMTGRGNFALSGQLGDVMKESARAALSWVRAEGEAYGIDPNFAQHYDLHVHVPAGAQPKDGPSAGIAMATALVSLLTGRVLRDDVAMTGEITLRGKVLPIGGVREKVLAAHRAGIRTIILPQRNLADLDEIPADVLAEVQFHGVEHVGQVIELALRAEASEAPVSVPESAVMPNLFQSDVEVLVH

lon1

Lon protease 1

815 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

91.13 kDa

MDIDQIEFKTNVFVLALRDVVVFPGMVVPLFVGRPKSMNALNAAMKEDKQIFLVTQKNATEETPTIDNLYQTGVMANILQLLKLPDGTLKVLVEGVKRFELLALNDEENFLTGDIQQVESDEQLDNDGVVLVRTIQERFQDYAALKKKIPSEVLKSVQKITDPNRLVDTISANLKLGIEEKQTLLEILTINDRLEHILKTIETEIDLLESEQRINSRVKKKMDQTQRNFYLNTKLQAIHEELGDSSEDGVSEFTRLKEQIEQAGMTKDALKVAEDELKKLKMMSPQSPEANIIRTYIEWLVSIPWKKRSRVSKDLNKAQTILDKQHYGLEKVKERIIEYLAVQKRVNKMKGPILCLVGPPGVGKTSLARSIAEATNRKYVRMSLGGVRDEAEIRGHRKTYLGALPGRVIQKMKTAGTRNPLFLLDEIDKMARDLRGDPASALLEVLDPEQNKAFNDHYLEVDYDLSDVMFVATSNSMDIPEALLDRMEIIDLAGYTENEKLNIATQHLLPREIKEHGLKQGELEVPSDTILKIIQTYTREAGVRLLDQSLAKICRKSLKEIVTNEAKAPITVTPDTLDKYLGVAKYRFGLADETNQIGQVAGLAWTRVGGDLLRIEATAMPGKGKNTSTGQLGSVMQESTQAAMSVIRSRSKELGLPDDFYEKQDVHLHFPEGAIKKDGPSAGIAICTAIASVLTQIPVRSDVAMTGEITLRGEVLPIGGLKEKLLAAARGGIKTVLIPYENVRDLAEISDEVKEGLDIHPVQWIDEVFKIALESFPNVENDEISAISMKDAEMGKLVANKQSTKEIQKKSPKRH

lon1

Lon protease 1

815 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

91.777 kDa

MFKLTRNKDEQSGSATFAMPLLPLRDIVVFPSMVVPLFVGRDKSVNALDKAMATDKKIFLAAQTKAKTDTPGESDIYRVGTVANILQILRLPDGTVKVLVEGDFRARISSFIPHPDHFFVSLEGLEESEDESVEIEALRRGVRAAFDAYSKHNKKINQEILDAVAAIDNASRLADTIAAYMPFKLDVKQKLLETLGVAKRLEKLFGQIRSEIEILQTEERIKGRVKKQMEKTQREYYLNEQMRAIQKEMGEKDDFKSELEELEKRIKRKKLSQEAAAKVRAEFKKLKLMSPMSAEATVVRNYIDWILSLPWYEKTRDKLDIDESIRILDEDHYGLEKPKERIIEYLAVQALVKRIKGPILCFVGPPGVGKTSLAKSIARAMNRNFIRLSLGGVRDEAEIRGHRRTYIGAMPGKIIQSLKKVKSNNPVFCLDEVDKMSMDFRGDPSAALLEVLDPEQNFSFNDHYLDLDYDLSEVFFITTANNLHSIPPPLRDRMEIIQIAGYTEFDKLNIGRNFLVAKQCKANGLSLDNIAFSDDMLLYIIRHYTKEAGVRNLEREIASICRKVAKEVVRRGPETRIELTEDLVQEYLGIPKFRYGVAEEKDEIGLAVGLAWTEFGGDILGIETVVMPGKGKVQITGKLGDVMQESAQAALSYVRSRAKRLGIDPDFYQNFDIHVHVPEGAIPKDGPSAGITMATSIVSALARIPVRSDLAMTGEITLRGRVLPIGGLKEKILAAHRALLKTVLIPKDNAKDLKDIPAKILEEIQVELVEHMDDVLRKAMVVPEDRELFHEEEAGAQQAVMFEQKPPAADEIRAH

lon1

Lon protease 1

814 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

90.863 kDa

MTDDRDKTNEDPEKIIEADFNPEDPDDADIAEDAKEGLVVATDVLPSTLPIIPLRPRPAFPGILTPMVFTGEKHVALAKRAVDTPSKMMGLVLAKEVDEPDSLENLHRFGVVGRVMKVLHTDDDSIHLLVNCLERFSIRELTESEEGLFARVDYHYATELSVNPELKAYSMAIITTLKELVQINPLYSEEIKMFLNRQSMDDPGRLTDFAANLTSGDGQLLQEILETIDVRNRIDKVLVLLKKELEVSRLQTKISKQIEQKVSAQQREFFLREQLKAIKKELGLEKEGKVSEIEKYQKRLKNLTLSEEAQKTIDEEIEKLRLIEPSSPEYNVSRNYLDWLTILPWGKFSKDNYNIERARRVLDRDHYGLKDVKDRILEFIAVGMLKGDISGSILCLVGPPGVGKTSIGKSIAAALNRTFYRFSLGGMRDEAEIKGHRRTYIGAMPGRFIQAMKSAGTANPVLMLDEIDKVGASFQGDPASALLEVLDPEQNSSFRDHYLDVPFDLSNVLFVATANQLDTIPAPLLDRMEIIRLAGYILEEKLEIARRYLIPKALENHGLKKGQVTIRKDALRAIIDGYAREAGVRNLENRIKKIMRHAAMEFSQGRTDKITVSKKDVAAILGKPIFTEEEVFEDVPGVVTGLAWTSMGGATLQIEATAMPSRNKGFKQTGQLGKVMVESSDIAYSYVMAHLEEYGADPEFFDKHFVHLHVPAGATPKDGPSAGVTMATALLSMITGKPVIKKLGMTGELTLTGKVLPIGGVKEKIIAVKRIGLTTVILPEANRKDFEELPDHLRENLSVHFAGDYRDVYQVAFG

lon1

Lon protease 1

811 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

89.947 kDa

MRFAQRPAMPERRSLPVLSLRDTVLFPGIATPITVGRLKTLRAVEAALRVEGEDKRIFAVAQRDAAEEPTASGLFSIGVIARITQVQRFGSGLQLVLYCERRAAAPRYTEVDGVIRAPVIELADLPLRPEEDGALEALSREVRERAVEYGRHRGAPEDVLKQFVGSMYGPAELVNHIAFYLDLPTPEKQALLEILSTEERMRSLALHLYRQIGIVETQEKIRTTVEEELGERQREIYLREQLRAIQKELGEEDDENAAARLEHKLQRANLPAEILQEARRDLARLRRMGRETSPEAQVLMTWLEWVADLPWSQRTDDHVDLDRARAILDEDHYGLGDVKDRVLEFLAVRKLRLEQARSEGERSRAISRGPILLFLGPPGTGKTSIAESIARALGRKYVRVSLGGARDEADIRGHRRTYVGAMPGRILQGIKRIGSKNPVIVLDEVDKLGASYQGDPGAALLEVLDPAQNDGFVDHYLGLPFDLSEVLFICTANFRETIPPPLFDRMEPALFAGYTEQEKHEIARKYLLPRQRKECGLREEQLRVTGTAIGGIISGYTREAGVRQLERTLGALARKAARRIAAGEIERAVVGADDDVKELLGRARMRLERRLQYDQPGVATGMYYTQMGGDIMHVEASVMPGKGDFVLTGQLGDVMKESGRAALSYARAHAAELGVPSDRLQRRDVHIHVPAGAVPKDGPSAGVTMAVALVSALSGRPVRSDIAMTGEITLRGTVLPIGGIKEKVLGAHRAGIFEILLPADNEADLDDLPAEVRSSLEFYLVNTLDEALARCLRLRSIRLEAPEEMPHARAS

lon1

Lon protease 1

808 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

90.775 kDa

MAEEPTILTPDGVENPDHDDLQFPARMEDILPEMLMVIPLYERPMFPKMMGPIIIEDMRLQKFILSQKDKKVPLFFALLLTRQDPDGQVKAPESADDFYDVGVVAKVIQISPLTIGEPLQFIVEIKARFDVVKLIKKEPLFQVEVKYWQEEKIKVTDELKAYSTAIIDSIKELVHLNPIFREGLSLLIERINLHEPGSLADFSAAMTTSSGPEIQKVLATRSVRKRIELALVLIKKELEISKLKVKISSRIEEQLSKQQREFFLKQQLQEIKKELGLTKDDTQTEMEKYENRIKDLHLPEEAQERIDEELEKIRLLGPSSPEFNVSRTYLDWLTMMPWGVYTKDNYSVKKARKILDDDHHGLDDVKDRIIELISVGSIKGELTGTILLLTGPPGVGKTSVGQSIARSLGRKFFRFSLGGMRDEAEIKGHRRTYIGAMPGKVIQAIKSCKSANPLIMLDEIDKIGASFRGDPASALLEVLDPEQNSDFLDHYLDVRFDLSKVLFICTANLLDTIPPALLDRMERIELPGYILAEKIAIARKHLIPRQMKHHGLRPSQIIISNPVLTAIVEGYAREAGVRGLETCIRKILRKTITSHLAGGLEKVRIRKRDLRGLLGRRLFAEEQVYSTPRVGVITGLAYTNMGGTTLYIESLAVPTGDSGFKQTGQLGKVMIESSEIAYSYIRFLLGDDSAAVKFFNKNFIHLHVPAGATPKDGPSAGITMACSLYSMATGKTIVPGVAMTGELTLTGLVMPIGGVKEKMIAARRAHVKQVILPKENEEDFDMLPDYIKEDLSAKFVETFEDVLKICFK

lon1

Lon protease 1

806 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

90.71 kDa

MDESKKARSGDKKKEKAVAGILPHSNKPARVPLIAVPSHPVFPGMFIPIVLISDSDMKAIDYAMKGNGIIALFVLNDKFLEKNNNNAQQKLIIDYSKDIYSVGVTGKIIKKINLPDGGYNIFVSTFDRIKFVKVVLNDKFPIIEIDYLKQIPVRKDDIQSKAVYGSILLRTKEIFAHRKMPEVQLNMVNIEDKGKLCDIVASTISSSKNDHQIVLETLNVKDRLKKVLELIYEELNLIEIQNKIAKGIQERLEKQQKEFFLKEQLKAIKAELGIGDKKSSDLEKLKTKLKALELKGEPLEVVEKELEKFSLLETSSAEYIVVRNYLELITELPWRDFKINFDKLDLQKSKKILDKTHYGMNEVKDRIIEYISVLKLRKTQKGAIILLVGPPGVGKTSIGAAIAKVLRTKFFRFSVGGMRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEVDKISASSYGDPFSVLLEVLDPEQNVRFRDHYLDLPFDISNVFFILTANSVETIPRPLLNRMEIIEISGYIDNEKIEIARKYLIPKVLSENGVDKDSLKFQSSSLVQIAQEYARDNGVRNFEKYLNKIVRKVARKLIENTEVKSYQISNDNLEEYVGVPVFRKESMPNAMYSGMVMGLAWTNYGGSTLMIETVKTESKVGGIKLTGRLGDVMKESANIAYTYVNSIKGDLSISKSFFEKNIIHLHIPEGATPKDGPSAGITIASAFISLALNKVVRPHLAMTGELSLTGNVMMIGGLKEKIIAAKRSGVEHIIVPKANRVDLEEIPTNIKSGINFYLVDNMREVIKLLF

lon1

Lon protease 1

795 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

89.312 kDa

MKDFLRLELPVLPLRNTVVLPHTTTGVDVGRLKSKRAVEEALSADRLLFLVTQKDPEVDDPAPEDLYAVGTLAVVKQAMRLPDGTLQVMVEARSRARLLSYVAAPYLRAVGEAIPEPPLKDPELARVLVNEVQEAFERYLQNHKTLRLDRYQQEAVKSTRDPAILADLVAHHATWTLEEKQTILETPEVEERLKRVLALLLRDLERFELDKKIAARVKEQMDQNQREYYLREQMKAIQKELGGGEDFLTEIEELRERIEKKGMPEPVKEKALKELKRLERMQPGSPEATVSRTYLDWLLEVPWTEADPEVLDISVTKRVLDEDHYGLKEVKERILEYLAVRQLTQGKEVKGHAPILCFVGPPGVGKTSLGKSIARSMNRRFHRISLGGVRDEAEIRGHRRTYIGALPGKIIQGMKQVGVVNPVFLLDEIDKLSSDWRGDPAAALLEVLDPEQNHTFTDHYLDVPYDLSKVFFITTANTLSTIPRPLLDRMEVIEIPGYTLHEKRAIARYFRWPFQVKEAGLEGRLEITDRAIERIVQEYTREAGVRNLDRELSKVARKAAKDYLEKPWEGVRVVDAEDLEAYLGVPKYRPDRAEKEPQVGAAQGLAWTPYGGTLLTIEAVAVPGTGKVNLTGNLGEVMKESAHAALTYLRAHREEWGLPEGFHKDYDLHIHVPEGATPKDGPSAGITIATALASALTGRPVRMDIAMTGEITLRGRVLPIGGVKEKLLAAHQAGIHRVILPKENAAELKEVPEEILKDLEIHFVEEVGEVLKLLLLPPPPPPAVQPDRPQPGVGA

lon1

Lon protease 1

793 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Belongs to the peptidase S16 family.

88.636 kDa

MSYVSGYVPVIPLKNSVLFPDISMPLRIGREKSIAALQKALRDNHWVILLTQKNPNASVDKIEDLYQVGTLAKVESFRMEEDGSYNIFVKAHQRVRLIHSRDSEGHIEAQTEALEDSGRLDKKTEEALLSSLRQLSDDLLDLLPGNTRQIREMIAEIEDLQTLVNMCAAYADINISDKQEILEIPLLKDRALKLLDRLQELKERLKIQRGIRDKLQESFQQNQKESILREQMRVIREELGDHEGEDLFAKFKDKIDKAGMPPEALELAKNQLRRLETSNSASPEYQMIRTHLELMTSLPWNQSSAQQDIDLEAAERVLNEDHYGLEKIKKRILQHLAVMKLRKSQQGSILMFIGPPGVGKTSLGKSIARALGKKYVRVALGGVRDDAEIRGHRRTYIGALPGRIIAGIKKAGENDPVFILDEIDKLTRGFGGDPASAMLEVLDPEQNNTFQDHYLDTPFDLSKVFFIATANSLEGIPLPLLDRMEVIDLSGYTVDEKRQIARSHLWPKQLKEHGLEENQLQITDQALTKLLTHYTREAGVRDLQRKIASICKHMSLKIIKSEGLPLLVEEQDLEDIFGAERFSADMIGSLLPPGVVTGLAWTPVGGDILFIESAQMPGKGNLLLTGQLGEVMQESAKIALTLLKSRLPLLDPLLDFAKKDIHVHVPAGAIPKDGPSAGITMLTSMASMLLNKPVDPKVAMTGEISLRGSVMPVGGIKEKVIAAHRAGVQEILLCKRNEKDLREIPEDIRKDLRFHFVEDVNEVLKITLGVNVPKWDQVQLPPPSPLSSTDAGT

lon1

Lon protease 1

774 amino acids

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions.

Belongs to the peptidase S16 family.

86.607 kDa

MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMHDHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYNEHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEPGRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRYEKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILEYLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSFSDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPKQIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRITVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITMATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIEDIPESVREGLTFILASHLDEVLEHALVGEKK