Protein
Hormone-sensitive lipase
Organism
Ictidomys tridecemlineatus
Function
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Similarity
Belongs to the 'GDXG' lipolytic enzyme family.
Sequence
MDLRTMTQSLVTLAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPALGSLLSVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALAYYAQRLLATNRPGGLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPSIRPFLQTISIGLVSFGEHYKRNESGLGVTASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEIEVLSSLANMASATVRVSRLISLPPEAFEMPLTSDPKLTVTISPPLAHTGPGPVLIRLISYDLREGQDSEELNSMVKSEGPRILELRPRPQQTSRSRSLVVXFHGGGFVAQTSKSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAVKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQSAASPSRLLSLMDPLLPLSVLSKCVSAYAGAETEEHPNSDEKALGMMGLVRRDTSLLLRDLRLGASSWLNSFLEFSGQKSQKTSAPTVESMRRSVSEAALAQPEGPVGTDSLKILTLKDLNLKSSSETSETPEMSLSVETLGPSTPSDVNFFLRPEDAREEAEAKEGLSAKDGSSRVSNAFPEGFHPRRTSQGATQMPLYSSPIVKNPFMSPLLAPDNMLKTLPPVHIVACALDPMLDDSXMFARRLRALGQPVTLRVVEDLPHGFLSLASLCRETRQAAELCVERIRLILTPPAAAAAAAPPPL