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LIP1P

Gene
LIP1P
Protein
Lipoyl synthase, chloroplastic
Organism
Chlamydomonas reinhardtii
Length
430 amino acids
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Mass
46.68 kDa
Sequence
MRSLATLHQSPASCSRSAPVAPCPARRANSSRRVARQGPRARASSPVVETESEDVDITPQIDAFEELVRLAVEKDPSLATLAEQHLRSKSKSAAPVSPFAAPSPGSPSASSMLGPSLGALPNQNKPAWLRQRAPQGEIYSGLKDQLRGLKLATVCEEAQCPNIGECWNGELATATIMLLGDTCTRGCRFCAVNTARTPPPPDPNEPVNTATAVASWGVGYVVLTSVDRDDMPDGGSEHFAATVRTLKQLRPGILVECLTPDFKGDLDAVRHLARSGLDVYAHNVETVERLQKRVRDPRAGYMQTLDVLRAAKECGVYTKSSIMLGLGETDDEVIDTMLDLKAVGVDIFTLGQYLQPTPHHLPVTEFVTPEKFEYWRKFGQEEIGFRYVASGPMVRSSYKAGEFFLHSMIESDRAKARAAQEGAAGRVRPL

Gene
LIP1P
Protein
Lipoyl synthase, chloroplastic
Organism
Arabidopsis thaliana
Length
394 amino acids
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (PubMed:12062419) (By similarity). Together with LIP2P and LIP2P2 is essential for de novo plastidial protein lipoylation during seed development (PubMed:23581459).
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Mass
43.622 kDa
Sequence
MMHHCSITKPTFSISISTQKLHHHSSKFLNLGFRIRCESGDVSSPLRTKAVSLSSEMEDSSSLKKSLMELEGKKSEPYPGGMPKMGPFTGRDPNVKKPAWLRQKAPQGERFQEVKESLSRLNLNTVCEEAQCPNIGECWNGGGDGVATATIMVLGDTCTRGCRFCAVKTSRNPPPPDPMEPENTAKAIASWGVDYIVITSVDRDDIPDGGSGHFAQTVKAMKRHKPDIMIECLTSDFRGDLEAVDTLVHSGLDVFAHNVETVKRLQRLVRDPRAGYEQSMSVLKHAKISKPGMITKTSIMLGLGETDEELKEAMADLRAIDVDILTLGQYLQPTPLHLTVKEYVTPEKFDFWKTYGESIGFRYVASGPLVRSSYRAGELFVKTMVKESYSKSLS

Gene
LIP1P
Protein
Lipoyl synthase, chloroplastic
Organism
Sorghum bicolor
Length
368 amino acids
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Mass
39.528 kDa
Sequence
MQSSLARPLRPPVLAGCGGRRGHGAPRGSVSVARCRAEAAPPTVGTASRAPAGPYTGRDPEVKKPAWLRQRAAQGDKYARLRESIGELKLNTVCVEAQCPNIGECWNGGGGAGGEGDGIATATIMVLGDTCTRGCRFCAVKTSNKPPPPDPLEPLNTALAVASWGVDYVVLTSVDRDDLPDGGSSHFAQTVRALKELKPGILVECLTSDFRGDLEAVSSLANSGLDVYAHNIETVRSLQRIVRDPRAGYDQSLAVLKHAKDCREGMITKSSIMLGLGETDEEVKQAMIDLRAIGVDILTLGQYLQPTERHLTVREYVTPEKFQFWKEYGESVGFRYVASGPLVRSSYRAGELFVQNLVRNNKTGSSSS

Gene
LIP1P
Protein
Lipoyl synthase, chloroplastic
Organism
Ricinus communis
Length
364 amino acids
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Mass
40.304 kDa
Sequence
MEQTLFNPSISMPKSFYHKHITISSRIQCQLSTNSPSSNTKTTTVTVPSKKTMGPYTGRDPNVKKPEWLRQRAPQGERFQEVKHSLSSLKLNTVCEEAQCPNIGECWNGGGDGIATATIMLLGDTCTRGCRFCAVKTSRNPSPPDPLEPQNTALAIASWGVDYIVLTSVDRDDLPDGGSGHFSETVQAMKKLKPEIMVECLTSDFRGDLEAVETLVHSGLDVFAHNIETVKRLQRIVRDPRAGYEQSLSVLKHAKHSKEGMITKSSIMLGLGETDDELKEAMADLRAIDVDILTLGQYLQPTPLHLTVKEYVTPEKFAFWKEYGESIGFRYVASGPMVRSSYRAGELFVKTMVKERSSNSAAKP

Gene
LIP1P
Protein
Lipoyl synthase, chloroplastic
Organism
Ostreococcus lucimarinus (strain CCE9901)
Length
324 amino acids
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Mass
35.487 kDa
Sequence
MCGPTATTVANAGTGGETIKGLPPGLKKPPWLRQRAPSGERFDYLSESLTGLKLNTVCEEAMCPNVGECWNGDTGTATVMLLGDTCTRGCRFCAVNTSQTPPPPDENEPENTAHAIAEWGVGYIVLTSVDRDDIPDGGSEHFARTVRTLKTIKSSVLVEALTPDFQGDMNAVAHLARSGLDVFAHNVETVERLQKRVRDPRANYEQSLAVLRHAKASKEGLVTKTSIMLGLGEEDEEIKQCMRACKEAGVDIFTLGQYLQPTPQHLPVKEFVTPEKFDFWKAYGEEVIGFRYVASGPLVRSSYKAGEFFIESMLRKDALDRGET