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LHP1

Gene
LHP1
Protein
Chromo domain-containing protein LHP1
Organism
Arabidopsis thaliana
Length
445 amino acids
Function
Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Transcriptional repressor that binds DNA on GAGA-like motif and 5'-(A/G/T)AACCCTA(A/G)-3' consensus motif in the promoters of target genes. Recognizes and binds histone H3 tails methylated at 'Lys-27' (H3K27me) but depleted in active histone marks such as H3K4me, leading to epigenetic repression. When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes (PubMed:27495811).
Mass
48.644 kDa
Sequence
MKGASGAVKKKPQVLNEAGEAETAVETVGESRKISGDGGFGSDDGGGGGGGGSGESILREIGDDRPTEDGDEEEEEDEDEDDGGDEEDEEGEGEGGQEERPKLDEGFYEIEAIRRKRVRKGKVQYLIKWRGWPETANTWEPLENLQSIADVIDAFEGSLKPGKPGRKRKRKYAGPHSQMKKKQRLTSTSHDATEKSDSSTSLNNSSLPDIPDPLDLSGSSLLNRDVEAKNAYVSNQVEANSGSVGMARQVRLIDNEKEYDPTLNELRGPVNNSNGAGCSQGGGIGSEGDNVRPNGLLKVYPKELDKNSRFIGAKRRKSGSVKRFKQDGSTSNNHTAPTDQNLTPDLTTLDSFGRIARMGNEYPGVMENCNLSQKTKIEELDITKILKPMSFTASVSDNVQEVLVTFLALRSDGKEALVDNRFLKAHNPHLLIEFYEQHLKYNRTP

Gene
LHP1
Protein
Probable chromo domain-containing protein LHP1
Organism
Oryza sativa subsp. japonica
Length
415 amino acids
Function
Structural component of heterochromatin involved in gene repression. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (By similarity).
Mass
45.675 kDa
Sequence
MARGKNHPDGEEEEAPAAAGEEEAPVEMDEEGEMEEEEEEEQGEGEGEERDEGEEEEEWEDAEEVEGGEESEQAAAEEEDSPLVVVEAEAAAPVVDGSPPKLAEGYYEIEDIRRRRLRKGKLQYLVKWRGWPESANTWEPLENLSACSDIIDAFEMRLQSPRPGRKRKRKITTTPVAGSNPSHGKRGRPRLDAKSHTRAPAPEPKQLPCRTSCRRATNCSSKTVAGLDASGSVVRNQLAQNIVQEGSSSVISRTPCQELPLSIRLTDQQNEHHLVNGSSNSENLVKVPPSQGGQVTGAKKRKSGNVRRFEQNKPTQGQGECGALVVAEDVGSTEGETGDKKKTEGCPNRVHITKIIKPVRFAAAVNNDVQQVSITFKALRSDGQEVMVDDKELKANNPLLLISYYEQCLRYNPTS

Gene
LHP1
Protein
Chromo domain protein LHP1
Organism
Solanum lycopersicum
Length
399 amino acids
Function
Structural component of heterochromatin involved in gene repression. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
Mass
44.098 kDa
Sequence
MKEGKRKSSRLQSEAAGAGSSRKLDLDGVAAERQERNGYPEDAGSKCEEEPVAGEGEGEGEEKDEAPEVVRVEKGDGDGVAKKVKPKLAEGFYEIETVRRRRTVKGKVYYLIKWRGWPESANTWEPETNLSSCTDIIDAYEESLKSGKLRRRKRKFGATQTHPMIKQQRRFSAPVATYNGPAVKVRIIEEPTPSPPLNVLKATDLVDSNGSELNSKVDEVVNGNGLRLREQNELNLKLSELKGATSTNGNPVDISGNGLTNGFPKVNGAEFYQSDRCTGAKKRKSGCVRRFKRETTSAVKDDTQDALAGGPLATFMQDGSHNHVMVADDSKDGYTITQLVNPVSYKASFSNDMLDVSVTFVAKRADGNLVLVDNKFLKMNNPLLLINFYEENMRYHPTE

Gene
LHP1
Protein
La protein homolog
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
275 amino acids
Function
Molecular chaperone that binds nascent RNA polymerase III transcripts, stabilizing these RNAs against exonucleases. Required for the 3' endonucleolytic cleavage that matures tRNA precursors and for efficient folding of certain pre-tRNAs. Cooperaes with GCD14 in the maturation of a subset of RNA polymerase III transcripts. Functions also in the assembly of certain RNA polymerase II-transcribed RNAs into RNPs. Binds and stabilizes newly synthesized U6 snRNA as well as precursors of U3 snRNA from degradation. Facilitates efficient Sm protein binding, thus assisting formation of the U4/U6 snRNP. Required fot Ty3 normal transposition frequency.
Mass
32.104 kDa
Sequence
MSEKPQQEEQEKPQSRRNSFAVIEFTPEVLDRCLKQVEFYFSEFNFPYDRFLRTTAEKNDGWVPISTIATFNRMKKYRPVDKVIEALRSSEILEVSADGENVKRRVPLDLTAARNARIEQNQRTLAVMNFPHEDVEASQIPELQENLEAFFKKLGEINQVRLRRDHRNKKFNGTVLVEFKTIPECEAFLKSYSNDDESNEILSYEGKKLSVLTKKQFDLQREASKSKNFSGRSRSFNGHKKKNLPKFPKNKKKNGKEESKEDSSAIADDDEEHKE